Results 71 to 80 of about 366,081 (322)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stereotactic Magnetic Resonance-guided Online Adaptive Radiotherapy for Oligometastatic Breast Cancer: A Case Report. [PDF]

, 2018
We present a case of durable local control achieved in a patient treated with stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) for an abdominal lymph node in the setting of oligometastatic breast cancer.
Cao, Minsong, Dang, Audrey, Lamb, James, Lee, Percy, Low, Daniel A, Raldow, Ann C, Steinberg, Michael L, Tyran, Marguerite   +7 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Gene duplication in an African cichlid adaptive radiation [PDF]

, 2014
Background Gene duplication is a source of evolutionary innovation and can contribute to the divergence of lineages; however, the relative importance of this process remains to be determined.
Joyce, Domino A, Joyce, Domino A., Jui, Ginger, Lunt, David H., Machado, Heather E, Machado, Heather E., Reilly, Christian R. L., Reilly, Christian R.L., Reilly, Christian RL, Renn, Suzy C. P., Renn, Suzy C.P., Renn, Suzy Cp, Renn, Suzy CP   +12 more
core   +2 more sources

Adaptive radiation in microbial microcosms [PDF]

Journal of Evolutionary Biology, 2005
AbstractIt has often been argued that evolutionary diversification is the result of divergent natural selection for specialization on alternative resources. I provide a comprehensive review of experiments that examine the ecology and genetics of resource specialization and adaptive radiation in microbial microcosms.
openaire   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

ARGOT: Accelerated radiative transfer on grids using oct-tree

, 2011
We present two types of numerical prescriptions that accelerate the radiative transfer calculation around point sources within a three-dimensional Cartesian grid by using the oct-tree structure for the distribution of radiation sources.
Abel, Abel, Abel, Aldrovandi, Anninos, Aubert, Barnes, Cen, Ciardi, Fryxell, Gnedin, González, Hasegawa, Hummer, Hummer, Ikeuchi, Iliev, Iliev, Janev, Kohji Yoshikawa, Krumholz, Kunasz, Masayuki Umemura, Mellema, Nakamoto, Ohsuga, Osterbrock, Pawlik, Petkova, Petkova, Raičević, Razoumov, Ricotti, Sokasian, Stone, Susa, Takashi Okamoto, Teyssier, Wise, Yajima, Yoshikawa   +40 more
core   +1 more source

Dosimetric impact of gastrointestinal air column in radiation treatment of pancreatic cancer [PDF]

, 2017
OBJECTIVE: Dosimetric evaluation of air column in gastrointestinal (GI) structures in intensity modulated radiation therapy (IMRT) of pancreatic cancer.
Cardenes, Higinia R., Corn, Jonathan B., Das, Indra J., Estabrook, Neil C., Ewing, Marvene M.   +4 more
core   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Sexual dimorphism in an adaptive radiation: Does intersexual niche differentiation result in ecological character displacement?

Ecology and Evolution, 2021
Evolutionary radiations are one plausible explanation for the rich biodiversity on Earth. Adaptive radiations are the most studied form of evolutionary radiations, and ecological opportunity has been identified as one factor permitting them.
Benjamin D. Wasiljew, Jobst Pfaender, Benjamin Wipfler, Mariam Gabelaia, Ilham Vemandra Utama, Letha Louisiana Wantania, Fabian Herder   +6 more
doaj   +1 more source