Results 151 to 160 of about 1,387,215 (249)

MR-Guided Adaptive Radiotherapy in Lung Cancer: Current Landscape and Future Directions. [PDF]

Cancers (Basel)
Ocanto A, Teja M, Gonsalves D, Vásquez W, Navarro-Domenech I, Moreno-Jimenez M, Guardia G, Urias D, Crespo S, Temes M, Hernández N, Senan S, Moghanaki D, Morera R, Azinovic I, Luna J, Couñago F.   +16 more
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Adaptive Radiotherapy in the Era of Image Guidance and Artificial Intelligence: A Critical Review. [PDF]

Cancers (Basel)
Srinivasan S, Njeh CF.
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Artificial intelligence applications in adaptive radiotherapy-a narrative review. [PDF]

Transl Cancer Res
Chen ZF, Larocque B, Wang J, Chen D, Liu W, Choi HHF, Raman S.   +6 more
europepmc   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Failure modes and effects analysis for clinical implementation of online adaptive radiotherapy: A systematic review. [PDF]

J Appl Clin Med Phys
Balaji D, Wegener S, Klüter S, Hackett SL.   +3 more
europepmc   +1 more source

Developing a web-based dashboard for adaptive radiotherapy workflows. [PDF]

J Appl Clin Med Phys
DiTusa C, Alexandrian A, Mavroidis P, Sargent E, Allen M, Schneider CW, Stathakis S.   +6 more
europepmc   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Online adaptive radiotherapy in pelvic and thoracic cancers - comparing toxicities, clinical outcomes and technical parameters between conventional image-guided radiotherapy and online adaptive radiotherapy - the study protocol for the prospective, registry-based cohort study (PRoART). [PDF]

BMC Med Imaging
Fischer LA, Fischer J, Scheele NC, Droege LH, Leu M, Guhlich M, Oelmann-Avendano JT, Hille A, Bendrich S, Donath S, Knaus O, Ziegler DA, Zwerenz CM, Anczykowski MZ, Ammon HE, Luise Bergau PF, Pagel CF, Schirmer MA, Wenzel AR, Frohn J, Bensberg J, Strauß A, Asendorf T, Schmitt D, Rieken S, El Shafie RA.   +25 more
europepmc   +1 more source