Results 21 to 30 of about 15,337 (259)

An Integrated SWOT-PESTLE-AHP Model Assessing Sustainability in Adaptive Reuse Projects

Applied Sciences, 2021
In the recent past, sustainable development has been considered a major issue for urban and regional studies. Adaptive reuse appears to be a practical solution for sustainable urban development. Beyond and in addition to a conceptual base consistent with
Ioannis Vardopoulos, Evangelia Tsilika, Efthymia Sarantakou, Antonis A. Zorpas, Luca Salvati, Paris Tsartas   +5 more
doaj   +1 more source

Research frameworks, methodologies, and assessment methods concerning the adaptive reuse of architectural heritage: a review

Built Heritage, 2021
With the growing trend towards preserving global architectural heritage, the adaptive reuse of built heritage buildings is becoming increasingly popular; as commentators have noted, this popularity can in part be attributed to the economic, cultural, and
Yuan Li, Long Zhao, Jingxiong Huang, Andrew Law   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Adaptive Reuse of Pos Bloc and M Bloc: The Intersection of Third Place, Nostalgia, and Circular Economy

Humaniora, 2023
The research examined the adaptive reuse strategy of heritage buildings that hold nostalgic value as commercial spaces with the third-place concept approach. The need for space facilities for urban communities continued to change based on the activities
Ade Ariyani Sari Fajarwati
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

S Sustainable Viability for Restoration and Adaptive Reuse of Sikh Era Havelis in Lahore, Pakistan

Sir Syed University Research Journal of Engineering and Technology, 2020
This research is concept based investigation of assessing the practical viability in terms of sustainability, for restoration and adaptive reuse of Sikh Era historic Havelis in Lahore.
Dr Sadia Farooq, Amna Khalid Qureshi
doaj