Results 131 to 140 of about 260,991 (264)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Optimization Design of Aircraft Parameters Based on Improved Adaptive Surrogate Model
Taiyuan Ligong Daxue xuebao[Purposes] Surrogate models are widely utilized in contemporary aircraft conceptual design for addressing optimization challenges, leveraging their rapid responsiveness.
LI Xiaochen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Domain Adaptation Using the Replay Buffer: Adaptive Sampling Using Domain-Specific Classifier
IEEE AccessDomain adaptation is a method used to reduce discrepancy between source and target domains and to enhance generalization performance by transforming the distribution of source images.
Seokmin Kim, Youngbae Hwang
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Sampling for the Measurement of Structured Surfaces
Structured surfaces are increasingly popular in manufacturing due to their ability to affect the function of a component, for example paintability and adhesiveness.
Wang, Jian
core
Non-uniform coverage estimators for distance sampling.
, 2009 Previously in the University eprints HAIRST pilot service at http://eprints.st-andrews.ac.uk/archive/00000445/Allocation of sampling effort in the context of distance sampling is considered.
Rexstad, Eric
core
Towards data-centric control of sensor networks through Bayesian dynamic linear modelling
, 2015 Wireless sensor networks usually operate in dynamic, stochastic environments. While the behaviour of individual nodes is important, they are better seen as contributors to a larger mission, and managing the sensing quality and performance of these ...
Dobson, Simon Andrew +3 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source