Results 1 to 10 of about 231 (76)

A Strategic Roadmap to Support Communication on and Acceptance of Surrogate Endpoints: The REnal Surrogacy accEpTance in Chronic Kidney Disease (RESET CKD) Collaboration. [PDF]

Adv Ther
Introduction Developing effective treatments in chronic, progressive diseases like chronic kidney disease (CKD) is challenging because patients may only experience relevant outcomes such as kidney failure after long periods of disease progression ...
Garcia Sanchez JJ, Trapero-Bertran M, Ciani O, Detournay B, Gesualdo L, Heerspink HJL, Inker LA, Sinha S, Wanner C, Little DJ, Sinsakul M, Nam YS, Taylor RS.   +12 more
europepmc   +2 more sources

A new framework for selecting environmental surrogates [PDF]

, 2015
Surrogate concepts are used in all sub-disciplines of environmental science. However, controversy remains regarding the extent to which surrogates are useful for resolving environmental problems.
Beger, Maria, Lindenmayer, David, Martin, Kathy, Gross, J., Longo, C., Westgate, M., McDowell, William H., Hunter, Malcolm, Caro, Tim, Barton, P., Westgate, Martin, Branquinho, C., Pierson, Jennifer, Lane, Peter, Beger, M., Calhoun, Aram, Mellin, C., Gross, John, Heino, Jani, Tulloch, A., Greig, Hamish, Hunter, M., Lindenmayer, D., Calhoun, A., Caro, T., Barton, Philip, Mellin, Camille, Salo, Hanna, Heino, J., Greig, H., Lane, P., Salo, H., Pierson, J., McDowell, William H, Tulloch, Ayesha, Branquinho, Cristina, Longo, Catherine, McDowell, W.H., Martin, K.   +38 more
core   +3 more sources

Reliable generative interpretable framework for efficient predictive analysis of air quality index

Air quality management is one of the most important sustainability goals in the era of Industry 5.0. The magnitude of air pollution and impact of drastic pollutants increase day by day despite the significant efforts of the environmental enthusiasts and ...
Shashi Kant Tiwari, Rajesh Kumar Dhanaraj, V. Malathi, Dursun Delen, M.K. Nallakaruppan, Dragan Pamucar, C. Sai Varun   +6 more
core   +1 more source

Bayesian adaptive designs in phase I/II clinical trials

, 2012
University of Minnesota Ph.D. dissertation. September 2012. Major: Biostatistics. Advisors:Bradley P. Carlin, Joseph S. Koopmeiners. 1 computer file (PDF); xi, 80 pages.Recently, many Bayesian methods have been developed for dose-finding when ...
Zhong, Wei
core  

Robust Semi-Parametric Inference in Semi-Supervised Settings

, 2017
In this dissertation, we consider semi-parametric estimation problems under semi-supervised (SS) settings, wherein the available data consists of a small or moderate sized labeled data (L), and a much larger unlabeled data (U). Such data arises naturally
Chakrabortty, Abhishek
core  

Models for providing improved care in residential care homes: a thematic literature review [PDF]

This Annotated Bibliography is one output from a review of the available research evidence to support improved care in residential care homes as the needs of older people intensify. Key findings The review identified extremely little published evidence
Clay, Diane, Szczepura, Ala, Hyde, Julia, Wild, Deidre, Nelson, S. (Sara)   +4 more
core  

Flexible evaluation of surrogacy in platform studies. [PDF]

Biostatistics, 2023
Sachs MC, Gabriel EE, Crippa A, Daniels MJ.   +3 more
europepmc   +1 more source

A surrogate endpoint-based provisional approval causal roadmap, illustrated by vaccine development. [PDF]

Biostatistics
Gilbert PB, Peng J, Han L, Lange T, Lu Y, Nie L, Shih MC, Waddy SP, Wiley K, Yann M, Zafari Z, Ghosh D, Follmann D, Juraska M, Díaz I.   +14 more
europepmc   +1 more source

Validation of a Longitudinal Marker as a Surrogate Using Mediation Analysis and Joint Modeling: Evolution of the PSA as a Surrogate of the Disease-Free Survival. [PDF]

Biom J
Le Coent Q, Legrand C, Dignam JJ, Rondeau V.   +3 more
europepmc   +1 more source

When advance directives clash with family consent: designing an operational framework for end-of-life decision-making in China and Korea. [PDF]

BMC Med Ethics
Luo S, Cho D, Cho J.
europepmc   +1 more source