Results 21 to 30 of about 250 (94)
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Nomlabofusp is a recombinant, cell‐penetrating human frataxin (hFXN) fusion protein in development for the treatment of Friedreich's ataxia (FRDA). This study evaluated whether nomlabofusp‐derived hFXN concentrations covary across accessible peripheral matrices and FRDA‐relevant tissues, supporting the feasibility of surrogate tissue sampling ...
Flavia De Toni +3 more
wiley +1 more source
Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 5, May 2026.ABSTRACT Aim Vaginal creation enables sexual intercourse in patients with Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome. However, long‐term psychosocial outcomes, particularly in Japanese patients, remain underreported. This study aimed to explore the long‐term psychosocial outcomes associated with different choices of vaginal creation in patients ...
Asuka Okunomiya +8 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 4, April 2026.Overall, PFS2 correlated more strongly with OS than PFS (0.83 vs. 0.69). PFS2 outperformed PFS in patients with targetable alterations and in those without. Our findings support using PFS2 as a candidate surrogate endpoint in glioblastoma trials. Implementing PFS2 balances trial feasibility with clinical relevance of outcomes.
Jesús Yaringaño +21 more
wiley +1 more source
Flesh and code: The cinematic lineage of AI replacing humans from Maria to Cassandra
AI Magazine, Volume 47, Issue 1, Spring 2026.Abstract This study explores the evolving representation of Artificial Intelligence (AI) characters in media and its intersection with contemporary technological issues, focusing on the paradoxical human desire for emotional and creative replacement.
Jiyoung Kim, Ki Han Kwon
wiley +1 more source
Online decision aids for contraceptive choices in women with chronic conditions: A systematic review
International Journal of Gynecology &Obstetrics, Volume 172, Issue 3, Page 1367-1380, March 2026.Abstract Background Women with chronic conditions face increased risks of unintended pregnancy and adverse maternal and perinatal outcomes. Tailored, online contraceptive decision aids might improve informed decision‐making and support reproductive health by promoting patient‐centered care in this population.
Begashaw Melaku Gebresillassie +2 more
wiley +1 more source
Pharmaceutical Statistics, Volume 25, Issue 2, March/April 2026.ABSTRACT Conditional marketing authorisation (CMA) is a path to early market access of new medicines addressing an unmet medical need in the European Union (EU), and similar concepts exist in other regulatory regions. For justifying a CMA, the benefit‐risk ratio has to be positive, and the applicant must be able to provide comprehensive data post ...
Xiaofei Liu +5 more
wiley +1 more source
Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management
Rheumatology &Autoimmunity, Volume 6, Issue 1, Page 16-38, March 2026.Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley +1 more source
Measurable residual disease (MRD) as a surrogate end point for clinical drug approval in acute myeloid leukemia (AML): Perspectives from the MRD Partnership and Alliance in AML Clinical Treatment Consortium. [PDF]
CancerBoyiadzis M +20 more
europepmc +1 more source