Results 111 to 120 of about 55,468 (275)

Adaptivity in Crashworthiness Calculations

Shock and Vibration, 1993
h-Adaptive finite element methods for nonlinear transient analysis by explicit time integration are described. Examples are given of adaptive calculations for simple components and prototype calculations for a full car model.
Ted Belytschko, Sang-Ho Lee, I-Sheng Yeh, Jerry I. Lin, Chen-Shyh Tsay, James M. Kennedy   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Self-guided transitions and creative idea search: adaptively choosing flexibility versus persistence in divergent and convergent thinking tasks

Royal Society Open Science
Adaptivity allows individuals to flexibly execute cognitive control to meet dynamically changing task demands while adhering to task goals. Such adaptivity is crucial for navigating complex problem spaces such as creative problem-solving.
Wilma Koutstaal
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

“You’re Not Allowed to Give Us the Solution, but Can You Guide Us towards It?”

PraxisForschungLehrer*innenBildung
In task-based mathematics classes, where several solution approaches may be valid, diagnosing students’ solution processes and adaptively supporting them is a significant challenge for teachers.
Sarina Scharnberg, Laura Schilling, Dominik Leiss   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Ecological testing of winter and spring barley varieties in arid conditions of the Republic of Kalmykia

Зерновое хозяйство России
Testing of agricultural crop varieties in various soil and climatic conditions allows estimating their response, which is very important when selecting a variety composition for a specific growing area.
A. A. Dontsova, D. P. Dontsov, R. N. Bragin, B. A. Goldvarg, M. V. Boktaev   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Tolerance Proportionality and Computational Stability in Adaptive Parallel-in-Time Runge–Kutta Methods

Algorithms
In this paper, we investigate how adaptive time-integration strategies can be effectively combined with parallel-in-time numerical methods for solving systems of ordinary differential equations.
Imre Fekete, Ferenc Izsák, Vendel P. Kupás, Gustaf Söderlind   +3 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source