Results 81 to 90 of about 55,468 (275)
, 2018 We present an adaptive variational procedure for unstructured meshes to capture fluid-fluid interfaces in two-phase flows. The two phases are modeled by the phase-field finite element formulation, which involves the conservative Allen-Cahn equation ...
Jaiman, Rajeev K., Joshi, Vaibhav
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
An Adaptive Strategy for Active Learning with Smooth Decision Boundary
, 2017 We present the first adaptive strategy for active learning in the setting of classification with smooth decision boundary. The problem of adaptivity (to unknown distributional parameters) has remained opened since the seminal work of Castro and Nowak ...
Carpentier, Alexandra +2 more
core
Optimal Unviersal Schedules for Discrete Broadcast [PDF]
, 2004 In this paper we study the scenario in which a server sends dynamic data over a single broadcast channel to a number of passive clients. We consider the data to consist of discrete packets, where each update is sent in a separate packet.
Bruck, Jehoshua +2 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
How Adaptive Is an Adaptive Test: Are All Adaptive Tests Adaptive?
Journal of Computerized Adaptive Testing, 2019 The primary distinguishing feature of computerized adaptive testing (CAT) is that sets of items that are administered to examinees are specifically selected for each examinee during the test process. This implies that examinees who respond differently to items on a test will get different sets of test items.
Mark Reckase, Unhee Ju, Sewon Kim
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Lipschitz Adaptivity with Multiple Learning Rates in Online Learning [PDF]
, 2019 We aim to design adaptive online learning algorithms that take advantage of any special structure that might be present in the learning task at hand, with as little manual tuning by the user as possible. A fundamental obstacle that comes up in the design
Koolen, Wouter M. +2 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source