Results 1 to 10 of about 1,136 (81)

Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line. [PDF]

Int J Mol Sci, 2021
In contrast to all transmembrane adenylyl cyclases except ADCY9, the cytosolic soluble adenylyl cyclase (ADCY10) is insensitive to forskolin stimulation and is uniquely modulated by calcium and bicarbonate ions. In the present paper, we focus on ADCY10 localization and a kinetic analysis of intracellular cAMP accumulation in response to human LH in the
Nguyen TMD, Filliatreau L, Klett D, Hai NV, Duong NT, Combarnous Y.   +5 more
europepmc   +8 more sources

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. [PDF]

Theranostics, 2021
Rationale: Ferroptosis, a newly identified form of regulated cell death, can be induced following the inhibition of cystine-glutamate antiporter system XC- because of the impaired uptake of cystine. However, the outcome following the accumulation of endogenous glutamate in lung adenocarcinoma (LUAD) has not yet been determined.
Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, Niu Y, Xu X, Guo S, Yang Y, Wang Z, Xue X, Gu C, Fang W, Sun J, Yu Y, Wang J.   +16 more
europepmc   +4 more sources

Association of Adenylate Cyclase 10 (ADCY10) Polymorphisms and Bone Mineral Density in Healthy Adults [PDF]

Calcified Tissue International, 2008
Phenotypic variation in bone mineral density (BMD) among healthy adults is influenced by both genetic and environmental factors. Sequence variations in the adenylate cyclase 10 (ADCY10) gene, which is also called soluble adenylate cyclase, have previously been associated with low spinal BMD in hypercalciuric patients.
Shoji Ichikawa, Daniel L. Koller, Leah R. Curry, Dongbing Lai, Xiaoling Xuei, Howard J. Edenberg, Siu L. Hui, Munro Peacock, Tatiana Foroud, Michael J. Econs   +9 more
openalex   +3 more sources

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments [PDF]

Journal of Cardiovascular Development and Disease, 2018
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength.
Sofya Pozdniakova, Yury Ladilov
openalex   +5 more sources

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates

Journal of Medicinal Chemistry, 2022
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is integral to successful male fertility: sAC activation is required for sperm motility and ability to undergo the acrosome reaction, two processes central to oocyte ...
Michael Miller, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Melanie Balbach, Navpreet Kaur, Lonny R. Levin, Jochen Buck, Maria Kehr, Sandrine Coquille, Joop van den Heuvel, Clemens Steegborn, Makoto Fushimi, Efrat Finkin-Groner, Robert W. Myers, Stacia Kargman, Nigel J. Liverton, David J. Huggins, Peter T. Meinke   +18 more
openalex   +4 more sources

Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)

ACS Medicinal Chemistry Letters, 2021
Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC inhibitors amenable for in vivo interrogation of sAC inhibition to assess its potential therapeutic applications. This work culminated in the identification
Makoto Fushimi, Hannes Buck, Melanie Balbach, Anna Gorovyy, Jacob Ferreira, Thomas Rossetti, Navpreet Kaur, Lonny R. Levin, Jochen Buck, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Efrat Finkin-Groner, Stacia Kargman, Mayako Michino, Michael A. Foley, Michael Miller, Nigel J. Liverton, David J. Huggins, Peter T. Meinke   +19 more
openalex   +5 more sources

Evidence of the Existence of Adenylyl Cyclase 10 (ADCY10) Ortholog Proteins in the Heads and Connecting Pieces of Boar Spermatozoa

Journal of Reproduction and Development, 2010
The aim of this study is to provide evidence of the existence of the adenylyl cyclase 10 (ADCY10) ortholog proteins in boar spermatozoa. Experiments with RT-PCR techniques, nucleotide sequence analyses and Northern blot analyses revealed that boar testes exclusively express approximately 5.1-kbp RNA, the nucleotide sequence of which is highly similar ...
Shunsuke Tate, Kazumi Nakamura, Chihiro Suzuki, Taichi Noda, Jibak Lee, Hiroshi Harayama   +5 more
openalex   +4 more sources

ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria

Human Reproduction, 2019
Can whole exome sequencing (WES) reveal a novel pathogenic variant in asthenozoospermia in a multiplex family including multiple patients?Patients were discovered to be homozygous for a rare 2-bp deletion in the ADCY10 coding region (c.1205_1206del, rs779944215).ADCY10 encodes for soluble adenylyl cyclase (sAC), which is the predominant adenylate ...
Arvand Akbari, Giovanni Battista Pipitone, Zahra Anvar, Mojtaba Jaafarinia, Maurizio Ferrari, Paola Carrera, Mehdi Totonchi   +6 more
openalex   +3 more sources

Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations. [PDF]

Imeta
Chimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans‐splicing and cis‐splicing between adjacent genes are also shown to generate chimeric RNAs. They influence tumor progression by coding fusion proteins, acting as long noncoding or circular RNAs, or altering ...
Wang Q, Yu S, Jie J, Elfman J, Xiong Z, Singh S, Lalani S, Wang Y, Li K, Cheng B, Gao Z, Gao X, Li H, Huang H.   +13 more
europepmc   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source