Results 1 to 10 of about 905 (129)

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments [PDF]

Journal of Cardiovascular Development and Disease, 2018
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity,
Sofya Pozdniakova, Yury Ladilov
doaj   +5 more sources

Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line. [PDF]

Int J Mol Sci, 2021
In contrast to all transmembrane adenylyl cyclases except ADCY9, the cytosolic soluble adenylyl cyclase (ADCY10) is insensitive to forskolin stimulation and is uniquely modulated by calcium and bicarbonate ions. In the present paper, we focus on ADCY10 localization and a kinetic analysis of intracellular cAMP accumulation in response to human LH in the
Nguyen TMD, Filliatreau L, Klett D, Hai NV, Duong NT, Combarnous Y.   +5 more
europepmc   +10 more sources

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. [PDF]

Theranostics, 2021
Rationale: Ferroptosis, a newly identified form of regulated cell death, can be induced following the inhibition of cystine-glutamate antiporter system XC- because of the impaired uptake of cystine. However, the outcome following the accumulation of endogenous glutamate in lung adenocarcinoma (LUAD) has not yet been determined.
Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, Niu Y, Xu X, Guo S, Yang Y, Wang Z, Xue X, Gu C, Fang W, Sun J, Yu Y, Wang J.   +16 more
europepmc   +5 more sources

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. [PDF]

J Med Chem, 2022
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is integral to successful male fertility: sAC activation is required for sperm motility and ability to undergo the acrosome reaction, two processes central to oocyte ...
Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, Levin LR, Buck J, Kehr M, Coquille S, van den Heuvel J, Steegborn C, Fushimi M, Finkin-Groner E, Myers RW, Kargman S, Liverton NJ, Huggins DJ, Meinke PT.   +18 more
europepmc   +5 more sources

Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)

ACS Medicinal Chemistry Letters, 2021
Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC inhibitors amenable for in vivo interrogation of sAC inhibition to assess its potential therapeutic applications. This work culminated in the identification
Peter T. Meinke, Peter T. Meinke, Clemens Steegborn, Efrat Finkin-Groner, Jochen Buck, Mayako Michino, Melanie Balbach, Hannes Buck, Navpreet Kaur, Nigel J. Liverton, David J. Huggins, David J. Huggins, Lonny R. Levin, Makoto Fushimi, Jacob Ferreira, Thomas Rossetti, Jonathan Quast, Joop van den Heuvel, Stacia Kargman, Anna Gorovyy, Michael Miller, Michael Foley   +21 more
openaire   +7 more sources

Quantifying and mathematical modelling of the influence of soluble adenylate cyclase on cell cycle in human endothelial cells with Bayesian inference. [PDF]

J Cell Mol Med, 2022
Abstract Adenosine‐3′, 5′‐cyclic monophosphate (cAMP) produced by adenylate cyclases (ADCYs) is an established key regulator of cell homoeostasis. However, its role in cell cycle control is still controversially discussed. This study focussed on the impact of soluble HCO3− ‐activated ADCY10 on cell cycle progression.
Woranush W, Moskopp ML, Noll T, Dieterich P.   +3 more
europepmc   +2 more sources

Association of Adenylate Cyclase 10 (ADCY10) Polymorphisms and Bone Mineral Density in Healthy Adults [PDF]

Calcified Tissue International, 2008
Phenotypic variation in bone mineral density (BMD) among healthy adults is influenced by both genetic and environmental factors. Sequence variations in the adenylate cyclase 10 (ADCY10) gene, which is also called soluble adenylate cyclase, have previously been associated with low spinal BMD in hypercalciuric patients.
Shoji Ichikawa, Tatiana Foroud, Siu L. Hui, Leah R. Curry, Howard J. Edenberg, Michael J. Econs, Munro Peacock, Daniel L. Koller, Dongbing Lai, Xiaoling Xuei   +9 more
openaire   +5 more sources

Strategies to safely target widely expressed soluble adenylyl cyclase for contraception [PDF]

Frontiers in Pharmacology, 2022
In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira, Lonny R. Levin, Jochen Buck   +2 more
doaj   +2 more sources

Evidence of the Existence of Adenylyl Cyclase 10 (ADCY10) Ortholog Proteins in the Heads and Connecting Pieces of Boar Spermatozoa

Journal of Reproduction and Development, 2010
The aim of this study is to provide evidence of the existence of the adenylyl cyclase 10 (ADCY10) ortholog proteins in boar spermatozoa. Experiments with RT-PCR techniques, nucleotide sequence analyses and Northern blot analyses revealed that boar testes exclusively express approximately 5.1-kbp RNA, the nucleotide sequence of which is highly similar ...
Taichi Noda, Jibak Lee, Kazumi Nakamura, Shunsuke Tate, Hiroshi Harayama, Chihiro Suzuki   +5 more
openaire   +5 more sources

Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations. [PDF]

Imeta
Chimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans‐splicing and cis‐splicing between adjacent genes are also shown to generate chimeric RNAs. They influence tumor progression by coding fusion proteins, acting as long noncoding or circular RNAs, or altering ...
Wang Q, Yu S, Jie J, Elfman J, Xiong Z, Singh S, Lalani S, Wang Y, Li K, Cheng B, Gao Z, Gao X, Li H, Huang H.   +13 more
europepmc   +2 more sources