Results 11 to 20 of about 69 (55)

Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel

Frontiers in Endocrinology, 2021
BackgroundInfertility affects about 7% of the general male population. The underlying cause of male infertility is undefined in about 50% of cases (idiopathic infertility).
Vincenza Precone, Rossella Cannarella, Stefano Paolacci, Gian Maria Busetto, Tommaso Beccari, Liborio Stuppia, Gerolamo Tonini, Alessandra Zulian, Giuseppe Marceddu, Aldo E. Calogero, Matteo Bertelli, Matteo Bertelli, Matteo Bertelli   +12 more
doaj   +1 more source

Landscape of Variability in Chemosensory Genes Associated With Dietary Preferences in Indian Population: Analysis of 1029 Indian Genomes

Frontiers in Genetics, 2022
Perception and preferences for food and beverages determine dietary behaviour and health outcomes. Inherent differences in chemosensory genes, ethnicity, geo-climatic conditions, and sociocultural practices are other determinants.
P. Prakrithi, Pankaj Jha, Jushta Jaiswal, Disha Sharma, Disha Sharma, Rahul C. Bhoyar, Abhinav Jain, Abhinav Jain, Mohamed Imran, Mohamed Imran, Vigneshwar Senthilvel, Vigneshwar Senthilvel, Mohit Kumar Divakar, Mohit Kumar Divakar, Anushree Mishra, Vinod Scaria, Vinod Scaria, Sridhar Sivasubbu, Sridhar Sivasubbu, Mitali Mukerji, Mitali Mukerji   +20 more
doaj   +1 more source

In vivo characterization of sAC null sperm

Frontiers in Cell and Developmental Biology, 2023
Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and ...
Carla Ritagliati, Sylvia Ayoub, Melanie Balbach, Jochen Buck, Lonny R. Levin   +4 more
doaj   +1 more source

Transcriptome analysis revealed potential genes involved in thermogenesis in muscle tissue in cold-exposed lambs

Frontiers in Genetics, 2022
Cold tolerance is an important trait for sheep raised at high altitudes. Muscle tissue, comprising 30–40% of the total body mass, produces heat during cold exposure.
Kaixi Ji, Kaixi Ji, Dan Jiao, Guo Yang, Abraham Allan Degen, Jianwei Zhou, Hu Liu, Wenqiang Wang, Haitao Cong   +8 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

Cholangiocytes express an isoform of soluble adenylyl cyclase that is N‐linked glycosylated and secreted in extracellular vesicles

Traffic, Volume 24, Issue 9, Page 413-430, September 2023., 2023
We demonstrate the glucose‐dependent trafficking and maturation of a novel membrane‐enclosed N‐linked glycosylated isoform of soluble adenylyl cyclase that is released in extracellular vesicles. Abstract Soluble adenylyl cyclase (sAC)‐derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels ...
Simei Go, Hang Lam Li, Jung‐Chin Chang, Arthur J. Verhoeven, Ronald P. J. Oude Elferink   +4 more
wiley   +1 more source

Manipulation of bicarbonate concentration in sperm capacitation media improves in vitro fertilisation output in porcine species

Journal of Animal Science and Biotechnology, 2019
Background The in vivo concentration of bicarbonate (HCO3 −), one of the essential sperm capacitating effectors, varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation site.
Cristina Soriano-Úbeda, Jon Romero-Aguirregomezcorta, Carmen Matás, Pablo E. Visconti, Francisco A. García-Vázquez   +4 more
doaj   +1 more source

Novel approach for the detection of the vestiges of testicular mRNA splicing errors in mature spermatozoa of Japanese Black bulls.

PLoS ONE, 2013
There is a serious problem with the reduction of male reproductive performance of the livestock in the world. We have a hypothesis that the splicing error-caused derivation of aberrant sperm motility-related proteins may be one of its causal factors.
Taichi Noda, Mitsuhiro Sakase, Moriyuki Fukushima, Hiroshi Harayama   +3 more
doaj   +1 more source

Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation

Frontiers in Physiology, 2014
The evolutionarily conserved soluble adenylyl cyclase (sAC, adcy10) was recently identified as a unique source of cAMP in the cytoplasm and the nucleus. Its activity is regulated by bicarbonate and fine-tuned by calcium.
Jung-Chin eChang, Ronald eOude Elferink
doaj   +1 more source

Identification of genes for complex diseases using integrated analysis of multiple types of genomic data.

PLoS ONE, 2012
Various types of genomic data (e.g., SNPs and mRNA transcripts) have been employed to identify risk genes for complex diseases. However, the analysis of these data has largely been performed in isolation.
Hongbao Cao, Shufeng Lei, Hong-Wen Deng, Yu-Ping Wang   +3 more
doaj   +1 more source