Results 11 to 20 of about 1,136 (81)

Cholangiocytes express an isoform of soluble adenylyl cyclase that is N‐linked glycosylated and secreted in extracellular vesicles

Traffic, Volume 24, Issue 9, Page 413-430, September 2023., 2023
We demonstrate the glucose‐dependent trafficking and maturation of a novel membrane‐enclosed N‐linked glycosylated isoform of soluble adenylyl cyclase that is released in extracellular vesicles. Abstract Soluble adenylyl cyclase (sAC)‐derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels ...
Simei Go, Hang Lam Li, Jung‐Chin Chang, Arthur J. Verhoeven, Ronald P. J. Oude Elferink   +4 more
wiley   +1 more source

Adenylyl cyclase 2 expression and function in neurological diseases. [PDF]

CNS Neurosci Ther
Mutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Gray M, Nash KR, Yao Y.
europepmc   +2 more sources

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

XML Attenuates Ox‐LDL‐Induced Endothelial Progenitor Cell Senescence via Gria2 and cAMP Pathways

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT In‐stent restenosis (ISR) following percutaneous coronary intervention (PCI) is a critical clinical issue, often arising from endothelial injury and impaired repair mechanisms. Endothelial progenitor cells (EPCs), derived from bone marrow, play a key role in vascular health, but their function diminishes with aging and exposure to oxidised low‐
Jinjian Wu, Guotao Lu, Zhou Luo, Meng Cai, Qiankun He, Jie Su, Jianfeng Liu, Rong Wang, Chunyan Kuang   +8 more
wiley   +1 more source

Isolated asthenozoospermia: What should we know? A narrative review of literature

UroPrecision, Volume 3, Issue 2, Page 73-86, June 2025.
ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa, Khaled Almekaty, Ahmed Zoeir, Hussein Mamdoh, Ayman Mousa, Mohammed Abou‐elenein, Tarek Gameel, Maged Ragab   +7 more
wiley   +1 more source

Determination via an Integration Strategy of the Potential Dermal ECM Reconstruction Mechanism by Which the WAW Formula Alleviates Skin Aging

Journal of Cosmetic Dermatology, Volume 24, Issue 4, April 2025.
ABSTRACT Background Traditional Chinese medicine (TCM) treats skin conditions and delays aging using specific formulas. TCM links skin health to internal organ functions: kidney qi deficiency accelerates aging, whereas spleen deficiency leads to dry, loose skin from insufficient qi and blood. The renowned spleen‐tonifying and kidney‐nourishing formula “
Yingying Lin, Yunhee Chang, Yoojae Maeng, Xiaoxing Liu, Xinke Liu, Hong Meng, Fan Yi   +6 more
wiley   +1 more source

Patient‐derived xenograft model in cancer: establishment and applications

MedComm, Volume 6, Issue 2, February 2025.
This review presents the establishment and application of patient‐derived xenograft (PDX) models, underscoring their extensive application in various therapeutic strategies including chemotherapy, targeted therapy, delivery systems, combination therapy, antibody–drug conjugates, and radiotherapy.
Ao Gu, Jiatong Li, Meng‐Yao Li, Yingbin Liu   +3 more
wiley   +1 more source

Activation of motility and chemotaxis in the spermatozoa

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
Abstract Background Sperm motility and chemotaxis are important early steps in the interaction between sperm and oocytes during fertilization. Understanding these processes is essential for their basic biological and clinical applications. This review outlines advances in understanding the molecular mechanisms of sperm activation and chemotaxis over ...
Manabu Yoshida, Kaoru Yoshida
wiley   +1 more source

Bayesian Optimization–Enhanced Machine Learning for Osteosarcoma Risk Stratification Based on Sphingolipid Metabolism

Human Mutation, Volume 2025, Issue 1, 2025.
Background: Heterogenized sphingolipid metabolism (SM) drives osteosarcoma tumorigenesis and its tumor‐promoting microenvironment. State‐of‐the‐art bioinformatic tools, such as machine learning, are essential for dissecting the prognostic value of SM by investigating its molecular and cellular mechanisms.
Yujian Zhong, Ruyuan He, Zewen Jiang, Queran Lin, Fei Peng, Wenyi Jin, Minghua Ren   +6 more
wiley   +1 more source

Intracellular Mg2+ concentrations are differentially regulated in the sperm head and mid‐piece in acrosome reaction inducing conditions

The FASEB Journal, Volume 38, Issue 21, 15 November 2024.
Because Mg2+ complexes with ATP, changes in intracellular Mg2+ ([Mg2+]i), monitored with Mag‐520, reflect, in part, ATP levels. Mag‐520 allows the concomitant detection of [Mg2+]i and [Ca2+]i. [Mg2+]i increases under two conditions that reduce ATP: starvation and capacitation. Conversely, nutrient addition to starved sperm decrease Mag‐520 fluorescence.
C. Sánchez‐Cárdenas, J. L. De la Vega‐Beltrán, W. D. Weber, G. Orta, Y. Sánchez‐Guevara, A. Hernández‐Cruz, A. Darszon, P. E. Visconti   +7 more
wiley   +1 more source