In vivo characterization of sAC null sperm [PDF]
Frontiers in Cell and Developmental Biology, 2023 Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and ...
Carla Ritagliati +4 more
doaj +3 more sources
Manipulation of bicarbonate concentration in sperm capacitation media improves in vitro fertilisation output in porcine species [PDF]
Journal of Animal Science and Biotechnology, 2019 Background The in vivo concentration of bicarbonate (HCO3 −), one of the essential sperm capacitating effectors, varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation site.
Cristina Soriano-Úbeda +4 more
doaj +8 more sources
Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel [PDF]
Frontiers in Endocrinology, 2021 BackgroundInfertility affects about 7% of the general male population. The underlying cause of male infertility is undefined in about 50% of cases (idiopathic infertility).
Vincenza Precone +12 more
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Liver Transcriptome Profiling Identifies Key Genes Related to Lipid Metabolism in Yili Geese [PDF]
Animals (Basel), 2023 Simple Summary Lipid is an important research topic in geese, and glucose metabolism is inevitably closely related to lipid metabolism. The liver is usually used as the study material in lipid and glucose metabolism.
Dong H +8 more
europepmc +2 more sources
Frontiers in Physiology, 2022 In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti +8 more
doaj +2 more sources
Quantifying and mathematical modelling of the influence of soluble adenylate cyclase on cell cycle in human endothelial cells with Bayesian inference. [PDF]
J Cell Mol Med, 2022 Adenosine‐3′, 5′‐cyclic monophosphate (cAMP) produced by adenylate cyclases (ADCYs) is an established key regulator of cell homoeostasis. However, its role in cell cycle control is still controversially discussed.
Woranush W +3 more
europepmc +2 more sources
Cyclic AMP Rescue of Motility in Sperm Devoid of Soluble Adenylyl Cyclase. [PDF]
Int J Mol SciThe second messenger cAMP plays multiple critical roles in the control of sperm functions essential for male fertility, including motility. The enzyme soluble adenylyl cyclase (sAC; ADCY10) was shown genetically and pharmacologically to be the essential ...
Ayoub S +6 more
europepmc +2 more sources
Adenylate cyclase 10 promotes brown adipose tissue thermogenesis [PDF]
iScienceSummary: Brown adipose tissue (BAT) thermogenesis dissipates energy through heat production and thereby it opposes metabolic disease. It is mediated by mitochondrial membrane uncoupling, yet the mechanisms sustaining the mitochondrial membrane potential (
Anupam Das +10 more
doaj +2 more sources
Essential Role of CFTR in PKA‐Dependent Phosphorylation, Alkalinization, and Hyperpolarization During Human Sperm Capacitation [PDF]
Journal of Cellular Physiology, 2017 Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
L. C. P. Puga Molina +8 more
semanticscholar +3 more sources
Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm*♦ [PDF]
Journal of Biological Chemistry, 2013 Background: cAMP is essential for the acquisition of sperm fertilizing capacity. The presence of transmembrane adenylyl cyclases (tmACs) in sperm remains controversial.
E. Wertheimer +12 more
semanticscholar +3 more sources