Results 21 to 30 of about 1,136 (81)

David Garbers' Contributions to Chemotaxis Signaling in Sperm

Molecular Reproduction and Development, Volume 91, Issue 10, October 2024.
ABSTRACT This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm‐specific, unique Na+/H+ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel ...
U. B. Kaupp, Olivia Kendall
wiley   +1 more source

Pre‐clinical and early clinical considerations for the development of non‐hormonal contraceptives for men

Andrology, Volume 12, Issue 7, Page 1558-1567, October 2024.
Abstract Introduction This manuscript presents non‐hormonal male contraceptive development in the context of mitigating risk to investigators and investors. Objective The manuscript uses examples to illustrate drug development principles to move a project from discovery to development.
Daniel S. Johnston
wiley   +1 more source

Soluble adenylyl cyclase is an acid‐base sensor in rainbow trout red blood cells that regulates intracellular pH and haemoglobin–oxygen binding

Acta Physiologica, Volume 240, Issue 10, October 2024.
Abstract Aim To identify the physiological role of the acid‐base sensing enzyme, soluble adenylyl cyclase (sAC), in red blood cells (RBC) of the model teleost fish, rainbow trout. Methods We used: (i) super‐resolution microscopy to determine the subcellular location of sAC protein; (ii) live‐cell imaging of RBC intracellular pH (pHi) with specific sAC ...
Till S. Harter, Emma A. Smith, Cristina Salmerón, Angus B. Thies, Bryan Delgado, Rod W. Wilson, Martin Tresguerres   +6 more
wiley   +1 more source

Comparison of genetic and epigenetic profiles of periodontitis according to the presence of type 2 diabetes

MedComm, Volume 5, Issue 7, July 2024.
Periodontitis accompanied by type 2 diabetes exhibits significant hypomethylation of Fc gamma receptor‐related genes compared with periodontitis. Periodontitis accompanied by type 2 diabetes shows a notable increase in C>T base substitutions within Fc gamma receptor‐related genes compared with periodontitis.
Junho Kang, Hansong Lee, Ji‐Young Joo, Jae‐Min Song, Hyun‐Joo Kim, Yun Hak Kim, Hae Ryoun Park   +6 more
wiley   +1 more source

Supplementary data and simulation code - "ADCY10 is a key regulator of cell cycle control"

, 2021
Woranush Warunya, Mats-Leif Moskopp, Thomas Noll, Peter Dieterich   +3 more
openalex   +3 more sources

Identification and validation of a novel anoikis‐related prognostic model for prostate cancer

Molecular Genetics &Genomic Medicine, Volume 12, Issue 4, April 2024.
Our study has identified a novel anoikis‐related signature consisting of four genes, which demonstrated significant prognostic value for PCa patients. Our findings suggest that this signature could serve as a valuable tool for predicting patient outcomes and guiding personalized treatment strategies for PCa.
Peipei Zhang, Wenzhi Lv, Yang Luan, Wei Cai, Xiangde Min, Zhaoyan Feng   +5 more
wiley   +1 more source

A novel anoikis‐related prognostic signature associated with prognosis and immune infiltration landscape in lung adenocarcinoma

The Journal of Gene Medicine, Volume 26, Issue 1, January 2024.
Based on anoikis‐related genes, we developed a risk prediction model to provide individualized and precise treatment for lung adenocarcinoma patients. Patients in different risk groups need to be targeted for treatment. Abstract Background One of the most prevalent malignancies in the world is lung adenocarcinoma (LUAD), with a large number of people ...
Yue Liu, Shiqi Hu, Meixin Teng, Yang Qing, Xiao Dong, Linsong Chen, Kaixing Ai   +6 more
wiley   +1 more source

Molecular mechanisms of mammalian sperm capacitation, and its regulation by sodium‐dependent secondary active transporters

Reproductive Medicine and Biology, Volume 23, Issue 1, January/December 2024.
Abstract Background Mammalian spermatozoa have to be “capacitated” to be fertilization‐competent. Capacitation is a collective term for the physiological and biochemical changes in spermatozoa that occur within the female body. However, the regulatory mechanisms underlying capacitation have not been fully elucidated. Methods Previously published papers
Gen L. Takei
wiley   +1 more source

Use of whole-exome sequencing to identify a novel ADCY10 mutation in a patient with nephrolithiasis.

American journal of translational research
Nephrolithiasis is a prevalent condition with high morbidity, and the incidence and prevalence of nephrolithiasis have been increasing worldwide. Although dozens of monogenic reason of nephrolithiasis have been identified, the fraction of the disease caused by single genes has not been determined.
Chenyu, Wang, Ran, Du, Jieyuan, Jin, Yi, Dong, Jishi, Liu, Liangling, Fan, Rong, Xiang   +6 more
openaire   +1 more source

Quantifying and mathematical modelling of the influence of soluble adenylate cyclase on cell cycle in human endothelial cells with Bayesian inference. [PDF]

J Cell Mol Med, 2022
Woranush W, Moskopp ML, Noll T, Dieterich P.   +3 more
europepmc   +1 more source