Results 21 to 30 of about 627 (101)

Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery [PDF]

BMC Genomics
Background Gangba sheep as a famous breed of Tibetan sheep, its wool color is mainly white and black. Gangba wool is economically important as a high-quality raw material for Tibetan blankets and Tibetan serge.
Wentao Zhang, Cuicheng Luosang, Chao Yuan, Tingting Guo, Caihong Wei, Jianbin Liu, Zengkui Lu   +6 more
doaj   +2 more sources

Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation

Frontiers in Physiology, 2014
The evolutionarily conserved soluble adenylyl cyclase (sAC, adcy10) was recently identified as a unique source of cAMP in the cytoplasm and the nucleus. Its activity is regulated by bicarbonate and fine-tuned by calcium.
Jung-Chin eChang, Ronald eOude Elferink
doaj   +2 more sources

Differential role of bovine serum albumin and HCO3- in the regulation of GSK3 alpha during mouse sperm capacitation. [PDF]

Mol Hum Reprod
To become fertile, mammalian sperm are required to undergo capacitation in the female tract or in vitro in defined media containing ions (e.g. HCO3-, Ca2+, Na+, and Cl-), energy sources (e.g. glucose, pyruvate) and serum albumin (e.g.
Mohanty G, Mohanty G, Sanchez-Cardenas C, Paudel B, Tourzani DA, Salicioni AM, Santi CM, Gervasi MG, Pilsner JR, Darszon A, Visconti PE.   +10 more
europepmc   +2 more sources

Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel

Frontiers in Endocrinology, 2021
BackgroundInfertility affects about 7% of the general male population. The underlying cause of male infertility is undefined in about 50% of cases (idiopathic infertility).
Vincenza Precone, Rossella Cannarella, Stefano Paolacci, Gian Maria Busetto, Tommaso Beccari, Liborio Stuppia, Gerolamo Tonini, Alessandra Zulian, Giuseppe Marceddu, Aldo E. Calogero, Matteo Bertelli, Matteo Bertelli, Matteo Bertelli   +12 more
doaj   +1 more source

Landscape of Variability in Chemosensory Genes Associated With Dietary Preferences in Indian Population: Analysis of 1029 Indian Genomes

Frontiers in Genetics, 2022
Perception and preferences for food and beverages determine dietary behaviour and health outcomes. Inherent differences in chemosensory genes, ethnicity, geo-climatic conditions, and sociocultural practices are other determinants.
P. Prakrithi, Pankaj Jha, Jushta Jaiswal, Disha Sharma, Disha Sharma, Rahul C. Bhoyar, Abhinav Jain, Abhinav Jain, Mohamed Imran, Mohamed Imran, Vigneshwar Senthilvel, Vigneshwar Senthilvel, Mohit Kumar Divakar, Mohit Kumar Divakar, Anushree Mishra, Vinod Scaria, Vinod Scaria, Sridhar Sivasubbu, Sridhar Sivasubbu, Mitali Mukerji, Mitali Mukerji   +20 more
doaj   +1 more source

Soluble adenylyl cyclase contributes to imiquimod‐mediated inflammation and is a potential therapeutic target in psoriasis

Experimental Dermatology, 2023
Cyclic AMP (cAMP) has a key role in psoriasis pathogenesis, as indicated by the therapeutic efficacy of phosphodiesterase inhibitors that prevent the degradation of cAMP.
Jaewon You, M. Reilly, M. Eljalby, R. Bareja, M. Yusupova, N. Vyas, J. Bang, W. Ding, G. Desman, L. Miller, O. Elemento, R. Granstein, J. Zippin   +12 more
semanticscholar   +1 more source

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

bioRxiv, 2021
Soluble adenylyl cyclase (sAC: ADCY10) is essential for activating dormant sperm. Studies of freshly dissected mouse sperm identified sAC as needed for initiating capacitation and activating motility.
M. Balbach, Lubna Ghanem, Thomas Rossetti, N. Kaur, Carla Ritagliati, Jacob Ferreira, D. Krapf, L. Molina, C. Santi, J. N. Hansen, D. Wachten, M. Fushimi, P. Meinke, J. Buck, L. Levin   +14 more
semanticscholar   +1 more source

Manipulation of bicarbonate concentration in sperm capacitation media improves in vitro fertilisation output in porcine species

Journal of Animal Science and Biotechnology, 2019
Background The in vivo concentration of bicarbonate (HCO3 −), one of the essential sperm capacitating effectors, varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation site.
Cristina Soriano-Úbeda, Jon Romero-Aguirregomezcorta, Carmen Matás, Pablo E. Visconti, Francisco A. García-Vázquez   +4 more
doaj   +1 more source

Novel approach for the detection of the vestiges of testicular mRNA splicing errors in mature spermatozoa of Japanese Black bulls.

PLoS ONE, 2013
There is a serious problem with the reduction of male reproductive performance of the livestock in the world. We have a hypothesis that the splicing error-caused derivation of aberrant sperm motility-related proteins may be one of its causal factors.
Taichi Noda, Mitsuhiro Sakase, Moriyuki Fukushima, Hiroshi Harayama   +3 more
doaj   +1 more source

Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase

Interface Focus, 2021
Soluble adenylyl cyclase (sAC; ADCY10) is a bicarbonate (HCO3−)-regulated enzyme responsible for the generation of cyclic adenosine monophosphate (cAMP).
Tommaso Rossetti, S. Jackvony, J. Buck, L. Levin   +3 more
semanticscholar   +1 more source