GWAS Enhances Genomic Prediction Accuracy of Caviar Yield, Caviar Color and Body Weight Traits in Sturgeons Using Whole-Genome Sequencing Data. [PDF]
Int J Mol SciCaviar yield, caviar color, and body weight are crucial economic traits in sturgeon breeding. Understanding the molecular mechanisms behind these traits is essential for their genetic improvement.
Song H +6 more
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Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models [PDF]
Scientific Reports, 2016 Mammalian sperm acquire fertilizing capacity in the female tract in a process called capacitation. At the molecular level, capacitation requires protein kinase A activation, changes in membrane potential and an increase in intracellular calcium ...
Felipe A. Navarrete +12 more
semanticscholar +4 more sources
Transcriptome analysis revealed potential genes involved in thermogenesis in muscle tissue in cold-exposed lambs [PDF]
Frontiers in Genetics, 2022 Cold tolerance is an important trait for sheep raised at high altitudes. Muscle tissue, comprising 30–40% of the total body mass, produces heat during cold exposure.
Kaixi Ji +8 more
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Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery [PDF]
BMC GenomicsBackground Gangba sheep as a famous breed of Tibetan sheep, its wool color is mainly white and black. Gangba wool is economically important as a high-quality raw material for Tibetan blankets and Tibetan serge.
Wentao Zhang +6 more
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CatSper channels are regulated by protein kinase A [PDF]
Journal of Biological Chemistry, 2018 Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO3−
G. Orta +5 more
semanticscholar +3 more sources
Clinicopathological characteristics and genomic profiling of pure mucinous breast cancer [PDF]
BreastPurpose: Pure mucinous breast cancer (PMC) is a rare histological type with a favourable prognosis. However, cases with recurrence have been reported and diagnosed in clinical practice. The mechanisms underlying PMC recurrence remain unknown.
Qianyi Lu +13 more
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Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype [PDF]
Acta Pharmaceutica Sinica BObesity is a significant risk factor for cancer and is associated with breast cancer metastasis. Nevertheless, the mechanism by which alterations in systemic metabolism affect tumor microenvironment (TME) and consequently influence tumor metastasis ...
Chao Chen +13 more
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Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation
Frontiers in Physiology, 2014 The evolutionarily conserved soluble adenylyl cyclase (sAC, adcy10) was recently identified as a unique source of cAMP in the cytoplasm and the nucleus. Its activity is regulated by bicarbonate and fine-tuned by calcium.
Jung-Chin eChang, Ronald eOude Elferink
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CFTR/ENaC-dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC [PDF]
Journal of Biological Chemistry, 2018 To fertilize an egg, sperm must reside in the female reproductive tract to undergo several maturational changes that are collectively referred to as capacitation.
L. C. P. Puga Molina +11 more
semanticscholar +4 more sources
Various gene modification techniques to discover molecular targets for nonhormonal male contraceptives: A review. [PDF]
Int J Reprod Biomed, 2023 The identification and characterization of relevant targets are necessary for developing nonhormonal male contraceptives. The molecules must demonstrate that they are necessary for reproduction.
Yunaini L, Ari Pujianto D.
europepmc +3 more sources