Clinicopathological characteristics and genomic profiling of pure mucinous breast cancer [PDF]
BreastPurpose: Pure mucinous breast cancer (PMC) is a rare histological type with a favourable prognosis. However, cases with recurrence have been reported and diagnosed in clinical practice. The mechanisms underlying PMC recurrence remain unknown.
Qianyi Lu +13 more
doaj +2 more sources
Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm*♦ [PDF]
Journal of Biological Chemistry, 2013 Background: cAMP is essential for the acquisition of sperm fertilizing capacity. The presence of transmembrane adenylyl cyclases (tmACs) in sperm remains controversial.
E. Wertheimer +12 more
semanticscholar +3 more sources
Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models [PDF]
Scientific Reports, 2016 Mammalian sperm acquire fertilizing capacity in the female tract in a process called capacitation. At the molecular level, capacitation requires protein kinase A activation, changes in membrane potential and an increase in intracellular calcium ...
Felipe A. Navarrete +12 more
semanticscholar +4 more sources
CatSper channels are regulated by protein kinase A [PDF]
Journal of Biological Chemistry, 2018 Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO3−
G. Orta +5 more
semanticscholar +3 more sources
CFTR/ENaC-dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC [PDF]
Journal of Biological Chemistry, 2018 To fertilize an egg, sperm must reside in the female reproductive tract to undergo several maturational changes that are collectively referred to as capacitation.
L. C. P. Puga Molina +11 more
semanticscholar +4 more sources
Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations. [PDF]
ImetaChimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans‐splicing and cis‐splicing between adjacent genes are also shown to generate chimeric RNAs. They influence tumor progression by coding fusion proteins, acting as long noncoding or circular RNAs, or altering ...
Wang Q +13 more
europepmc +2 more sources
Activation of motility and chemotaxis in the spermatozoa. [PDF]
Reprod Med BiolAbstract Background Sperm motility and chemotaxis are important early steps in the interaction between sperm and oocytes during fertilization. Understanding these processes is essential for their basic biological and clinical applications. This review outlines advances in understanding the molecular mechanisms of sperm activation and chemotaxis over ...
Yoshida M, Yoshida K.
europepmc +2 more sources
Various gene modification techniques to discover molecular targets for nonhormonal male contraceptives: A review. [PDF]
Int J Reprod Biomed, 2023 The identification and characterization of relevant targets are necessary for developing nonhormonal male contraceptives. The molecules must demonstrate that they are necessary for reproduction.
Yunaini L, Ari Pujianto D.
europepmc +3 more sources
Adenylyl cyclase 2 expression and function in neurological diseases. [PDF]
CNS Neurosci TherMutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Gray M, Nash KR, Yao Y.
europepmc +2 more sources
Editorial: Editors' showcase 2022: insights in molecular and cellular reproduction. [PDF]
Front Cell Dev Biol, 2023 Ju JQ, Fissore RA, Sun SC.
europepmc +3 more sources