Results 31 to 40 of about 1,033 (153)

Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice.

PLoS ONE, 2008
BackgroundMammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy) represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases.
Jeanne Farrell, Lavoisier Ramos, Martin Tresguerres, Margarita Kamenetsky, Lonny R Levin, Jochen Buck   +5 more
doaj   +2 more sources

Differential role of bovine serum albumin and HCO3- in the regulation of GSK3 alpha during mouse sperm capacitation. [PDF]

Mol Hum Reprod
To become fertile, mammalian sperm are required to undergo capacitation in the female tract or in vitro in defined media containing ions (e.g. HCO3-, Ca2+, Na+, and Cl-), energy sources (e.g. glucose, pyruvate) and serum albumin (e.g.
Mohanty G, Mohanty G, Sanchez-Cardenas C, Paudel B, Tourzani DA, Salicioni AM, Santi CM, Gervasi MG, Pilsner JR, Darszon A, Visconti PE.   +10 more
europepmc   +2 more sources

Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations. [PDF]

Imeta
Chimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans‐splicing and cis‐splicing between adjacent genes are also shown to generate chimeric RNAs. They influence tumor progression by coding fusion proteins, acting as long noncoding or circular RNAs, or altering ...
Wang Q, Yu S, Jie J, Elfman J, Xiong Z, Singh S, Lalani S, Wang Y, Li K, Cheng B, Gao Z, Gao X, Li H, Huang H.   +13 more
europepmc   +2 more sources

Activation of motility and chemotaxis in the spermatozoa. [PDF]

Reprod Med Biol
Abstract Background Sperm motility and chemotaxis are important early steps in the interaction between sperm and oocytes during fertilization. Understanding these processes is essential for their basic biological and clinical applications. This review outlines advances in understanding the molecular mechanisms of sperm activation and chemotaxis over ...
Yoshida M, Yoshida K.
europepmc   +2 more sources

Adenylyl cyclase 2 expression and function in neurological diseases. [PDF]

CNS Neurosci Ther
Mutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Gray M, Nash KR, Yao Y.
europepmc   +2 more sources

Landscape of Variability in Chemosensory Genes Associated With Dietary Preferences in Indian Population: Analysis of 1029 Indian Genomes

Frontiers in Genetics, 2022
Perception and preferences for food and beverages determine dietary behaviour and health outcomes. Inherent differences in chemosensory genes, ethnicity, geo-climatic conditions, and sociocultural practices are other determinants.
P. Prakrithi, Pankaj Jha, Jushta Jaiswal, Disha Sharma, Disha Sharma, Rahul C. Bhoyar, Abhinav Jain, Abhinav Jain, Mohamed Imran, Mohamed Imran, Vigneshwar Senthilvel, Vigneshwar Senthilvel, Mohit Kumar Divakar, Mohit Kumar Divakar, Anushree Mishra, Vinod Scaria, Vinod Scaria, Sridhar Sivasubbu, Sridhar Sivasubbu, Mitali Mukerji, Mitali Mukerji   +20 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

Cholangiocytes express an isoform of soluble adenylyl cyclase that is N‐linked glycosylated and secreted in extracellular vesicles

Traffic, Volume 24, Issue 9, Page 413-430, September 2023., 2023
We demonstrate the glucose‐dependent trafficking and maturation of a novel membrane‐enclosed N‐linked glycosylated isoform of soluble adenylyl cyclase that is released in extracellular vesicles. Abstract Soluble adenylyl cyclase (sAC)‐derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels ...
Simei Go, Hang Lam Li, Jung‐Chin Chang, Arthur J. Verhoeven, Ronald P. J. Oude Elferink   +4 more
wiley   +1 more source

Soluble adenylyl cyclase contributes to imiquimod‐mediated inflammation and is a potential therapeutic target in psoriasis

Experimental Dermatology, 2023
Cyclic AMP (cAMP) has a key role in psoriasis pathogenesis, as indicated by the therapeutic efficacy of phosphodiesterase inhibitors that prevent the degradation of cAMP.
Jaewon You, M. Reilly, M. Eljalby, R. Bareja, M. Yusupova, N. Vyas, J. Bang, W. Ding, G. Desman, L. Miller, O. Elemento, R. Granstein, J. Zippin   +12 more
semanticscholar   +1 more source

Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells

Food Science &Nutrition, Volume 11, Issue 6, Page 3141-3153, June 2023., 2023
In summary, our study uncovers the elevated expression of NLRP3 in restenosis artery wall, making it a novel therapeutic target for the disease. More importantly, we found that mulberry extract plays multiple regulatory roles in the formation of restenosis.
Yuting Liu, Kefan Wang, Shuofei Yang, Guanhua Xue, Liming Lu   +4 more
wiley   +1 more source