Results 31 to 40 of about 69 (55)

Determination via an Integration Strategy of the Potential Dermal ECM Reconstruction Mechanism by Which the WAW Formula Alleviates Skin Aging

Journal of Cosmetic Dermatology, Volume 24, Issue 4, April 2025.
ABSTRACT Background Traditional Chinese medicine (TCM) treats skin conditions and delays aging using specific formulas. TCM links skin health to internal organ functions: kidney qi deficiency accelerates aging, whereas spleen deficiency leads to dry, loose skin from insufficient qi and blood. The renowned spleen‐tonifying and kidney‐nourishing formula “
Yingying Lin, Yunhee Chang, Yoojae Maeng, Xiaoxing Liu, Xinke Liu, Hong Meng, Fan Yi   +6 more
wiley   +1 more source

Patient‐derived xenograft model in cancer: establishment and applications

MedComm, Volume 6, Issue 2, February 2025.
This review presents the establishment and application of patient‐derived xenograft (PDX) models, underscoring their extensive application in various therapeutic strategies including chemotherapy, targeted therapy, delivery systems, combination therapy, antibody–drug conjugates, and radiotherapy.
Ao Gu, Jiatong Li, Meng‐Yao Li, Yingbin Liu   +3 more
wiley   +1 more source

Activation of motility and chemotaxis in the spermatozoa

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
Abstract Background Sperm motility and chemotaxis are important early steps in the interaction between sperm and oocytes during fertilization. Understanding these processes is essential for their basic biological and clinical applications. This review outlines advances in understanding the molecular mechanisms of sperm activation and chemotaxis over ...
Manabu Yoshida, Kaoru Yoshida
wiley   +1 more source

Bayesian Optimization–Enhanced Machine Learning for Osteosarcoma Risk Stratification Based on Sphingolipid Metabolism

Human Mutation, Volume 2025, Issue 1, 2025.
Background: Heterogenized sphingolipid metabolism (SM) drives osteosarcoma tumorigenesis and its tumor‐promoting microenvironment. State‐of‐the‐art bioinformatic tools, such as machine learning, are essential for dissecting the prognostic value of SM by investigating its molecular and cellular mechanisms.
Yujian Zhong, Ruyuan He, Zewen Jiang, Queran Lin, Fei Peng, Wenyi Jin, Minghua Ren   +6 more
wiley   +1 more source

Intracellular Mg2+ concentrations are differentially regulated in the sperm head and mid‐piece in acrosome reaction inducing conditions

The FASEB Journal, Volume 38, Issue 21, 15 November 2024.
Because Mg2+ complexes with ATP, changes in intracellular Mg2+ ([Mg2+]i), monitored with Mag‐520, reflect, in part, ATP levels. Mag‐520 allows the concomitant detection of [Mg2+]i and [Ca2+]i. [Mg2+]i increases under two conditions that reduce ATP: starvation and capacitation. Conversely, nutrient addition to starved sperm decrease Mag‐520 fluorescence.
C. Sánchez‐Cárdenas, J. L. De la Vega‐Beltrán, W. D. Weber, G. Orta, Y. Sánchez‐Guevara, A. Hernández‐Cruz, A. Darszon, P. E. Visconti   +7 more
wiley   +1 more source

Clinicopathological characteristics and genomic profiling of pure mucinous breast cancer

Breast
Purpose: Pure mucinous breast cancer (PMC) is a rare histological type with a favourable prognosis. However, cases with recurrence have been reported and diagnosed in clinical practice. The mechanisms underlying PMC recurrence remain unknown.
Qianyi Lu, Hanxing Zhou, Jianwei Zhang, Kaping Lee, Limin Chen, Ruoxi Hong, Kuikui Jiang, Fei Xu, Wen Xia, Boyang Cao, Jingmin Zhang, Kang Shao, Peng Sun, Shusen Wang   +13 more
doaj   +1 more source

David Garbers' Contributions to Chemotaxis Signaling in Sperm

Molecular Reproduction and Development, Volume 91, Issue 10, October 2024.
ABSTRACT This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm‐specific, unique Na+/H+ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel ...
U. B. Kaupp, Olivia Kendall
wiley   +1 more source

Supplementary data and simulation code - "ADCY10 is a key regulator of cell cycle control"

, 2021
Woranush Warunya, Mats-Leif Moskopp, Thomas Noll, Peter Dieterich   +3 more
openalex   +3 more sources

Pre‐clinical and early clinical considerations for the development of non‐hormonal contraceptives for men

Andrology, Volume 12, Issue 7, Page 1558-1567, October 2024.
Abstract Introduction This manuscript presents non‐hormonal male contraceptive development in the context of mitigating risk to investigators and investors. Objective The manuscript uses examples to illustrate drug development principles to move a project from discovery to development.
Daniel S. Johnston
wiley   +1 more source

Soluble adenylyl cyclase is an acid‐base sensor in rainbow trout red blood cells that regulates intracellular pH and haemoglobin–oxygen binding

Acta Physiologica, Volume 240, Issue 10, October 2024.
Abstract Aim To identify the physiological role of the acid‐base sensing enzyme, soluble adenylyl cyclase (sAC), in red blood cells (RBC) of the model teleost fish, rainbow trout. Methods We used: (i) super‐resolution microscopy to determine the subcellular location of sAC protein; (ii) live‐cell imaging of RBC intracellular pH (pHi) with specific sAC ...
Till S. Harter, Emma A. Smith, Cristina Salmerón, Angus B. Thies, Bryan Delgado, Rod W. Wilson, Martin Tresguerres   +6 more
wiley   +1 more source