Results 41 to 50 of about 978 (151)

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

Cholangiocytes express an isoform of soluble adenylyl cyclase that is N‐linked glycosylated and secreted in extracellular vesicles

Traffic, Volume 24, Issue 9, Page 413-430, September 2023., 2023
We demonstrate the glucose‐dependent trafficking and maturation of a novel membrane‐enclosed N‐linked glycosylated isoform of soluble adenylyl cyclase that is released in extracellular vesicles. Abstract Soluble adenylyl cyclase (sAC)‐derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels ...
Simei Go, Hang Lam Li, Jung‐Chin Chang, Arthur J. Verhoeven, Ronald P. J. Oude Elferink   +4 more
wiley   +1 more source

The roles of soluble adenylate cyclase in cell cycle control of endothelial cells [PDF]

, 2022
The soluble form of ADCYs, ADCY10, is ubiquitously expressed in the cytoplasm and distinct organelles including cell nucleus. In contrast to its membrane-associated isoforms (ADCY1-9) which are stimulated by G-protein-coupled receptors, ADCY10 is ...
Woranush, Warunya
core   +1 more source

Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells

Food Science &Nutrition, Volume 11, Issue 6, Page 3141-3153, June 2023., 2023
In summary, our study uncovers the elevated expression of NLRP3 in restenosis artery wall, making it a novel therapeutic target for the disease. More importantly, we found that mulberry extract plays multiple regulatory roles in the formation of restenosis.
Yuting Liu, Kefan Wang, Shuofei Yang, Guanhua Xue, Liming Lu   +4 more
wiley   +1 more source

Reproductive consequences of electrolyte disturbances in domestic animals [PDF]

, 2022
Electrolyte balance is essential to maintain homeostasis in the body. The most crucial electrolytes are sodium (Na+), potassium (K+), magnesium (Mg2+), chloride (Cl?), and calcium (Ca2+).
Araujo, Jose Pedro, Galeska, Elzbieta, Kowalczyk, Alicja, Wrzecinska, Marcjanna   +3 more
core   +1 more source

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice

Aging Cell, Volume 22, Issue 5, May 2023., 2023
Bifunctional immunotherapeutic HCW9218 functions as a novel SNC‐reducing and senomorphic agent in mice. Subcutaneous administration of HCW9218 activates NK, innate lymphoid group‐1, and CD8+ T cells, and neutralizes TGF‐ß to reduce senescent cells (SNC‐reducing) and SASP (senomorphic) leading to lower chronic inflammation and restored tissue ...
Niraj Shrestha, Pallavi Chaturvedi, Xiaoyun Zhu, Michael J. Dee, Varghese George, Christopher Janney, Jack O. Egan, Bai Liu, Mark Foster, Lynne Marsala, Pamela Wong, Celia C. Cubitt, Jennifer A. Foltz, Jennifer Tran, Timothy Schappe, Karin Hsiao, Gilles M. Leclerc, Lijing You, Christian Echeverri, Catherine Spanoudis, Ana Carvalho, Leah Kanakaraj, Crystal Gilkes, Nicole Encalada, Lin Kong, Meng Wang, Byron Fang, Zheng Wang, Jin‐an Jiao, Gabriela J. Muniz, Emily K. Jeng, Nicole Valdivieso, Liying Li, Richard Deth, Melissa M. Berrien‐Elliott, Todd A. Fehniger, Peter R. Rhode, Hing C. Wong   +37 more
wiley   +1 more source

Determination via an Integration Strategy of the Potential Dermal ECM Reconstruction Mechanism by Which the WAW Formula Alleviates Skin Aging. [PDF]

J Cosmet Dermatol
ABSTRACT Background Traditional Chinese medicine (TCM) treats skin conditions and delays aging using specific formulas. TCM links skin health to internal organ functions: kidney qi deficiency accelerates aging, whereas spleen deficiency leads to dry, loose skin from insufficient qi and blood. The renowned spleen‐tonifying and kidney‐nourishing formula “
Lin Y, Chang Y, Maeng Y, Liu X, Liu X, Meng H, Yi F.   +6 more
europepmc   +2 more sources

Adenylyl cyclases (ACs) in GtoPdb v.2023.1 [PDF]

, 2023
Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [11]) are typically made up of two clusters of six ...
Dessauer, Carmen W., Ostrom, Rennolds, Seifert, Roland, Watts, Val J.   +3 more
core   +2 more sources

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, Volume 12, Issue 12, December 2022., 2022
Myoglobin (MB) is highly expressed in brown adipose tissue (BAT), its expression level increases with adipocyte differentiation and it is temperature dependently regulated in vivo. Expression levels of MB in brown and white adipocytes control mitochondrial respiratory capacity and increase acute response to adrenergic signalling and lipolysis.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
wiley   +1 more source

Biphasic Role of Calcium in Mouse Sperm Capacitation Signaling Pathways [PDF]

, 2015
Mammalian sperm acquire fertilizing ability in the female tract in a process known as capacitation. At the molecular level, capacitation is associated with up-regulation of a cAMP-dependent pathway, changes in intracellular pH, intracellular Ca2+, and an
Alvau, Antonio, Darszon, Alberto, Escoffier, Jessica, García Vázquez, Francisco A., Krapf, Dario, Navarrete, Felipe A., Salicioni, Ana M., Sánchez Cárdenas, Claudia, Visconti, Pablo E.   +8 more
core   +1 more source