Results 41 to 50 of about 1,033 (153)

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

bioRxiv, 2021
Soluble adenylyl cyclase (sAC: ADCY10) is essential for activating dormant sperm. Studies of freshly dissected mouse sperm identified sAC as needed for initiating capacitation and activating motility.
M. Balbach, Lubna Ghanem, Thomas Rossetti, N. Kaur, Carla Ritagliati, Jacob Ferreira, D. Krapf, L. Molina, C. Santi, J. N. Hansen, D. Wachten, M. Fushimi, P. Meinke, J. Buck, L. Levin   +14 more
semanticscholar   +1 more source

The roles of soluble adenylate cyclase in cell cycle control of endothelial cells [PDF]

, 2022
The soluble form of ADCYs, ADCY10, is ubiquitously expressed in the cytoplasm and distinct organelles including cell nucleus. In contrast to its membrane-associated isoforms (ADCY1-9) which are stimulated by G-protein-coupled receptors, ADCY10 is ...
Woranush, Warunya
core   +1 more source

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice

Aging Cell, Volume 22, Issue 5, May 2023., 2023
Bifunctional immunotherapeutic HCW9218 functions as a novel SNC‐reducing and senomorphic agent in mice. Subcutaneous administration of HCW9218 activates NK, innate lymphoid group‐1, and CD8+ T cells, and neutralizes TGF‐ß to reduce senescent cells (SNC‐reducing) and SASP (senomorphic) leading to lower chronic inflammation and restored tissue ...
Niraj Shrestha, Pallavi Chaturvedi, Xiaoyun Zhu, Michael J. Dee, Varghese George, Christopher Janney, Jack O. Egan, Bai Liu, Mark Foster, Lynne Marsala, Pamela Wong, Celia C. Cubitt, Jennifer A. Foltz, Jennifer Tran, Timothy Schappe, Karin Hsiao, Gilles M. Leclerc, Lijing You, Christian Echeverri, Catherine Spanoudis, Ana Carvalho, Leah Kanakaraj, Crystal Gilkes, Nicole Encalada, Lin Kong, Meng Wang, Byron Fang, Zheng Wang, Jin‐an Jiao, Gabriela J. Muniz, Emily K. Jeng, Nicole Valdivieso, Liying Li, Richard Deth, Melissa M. Berrien‐Elliott, Todd A. Fehniger, Peter R. Rhode, Hing C. Wong   +37 more
wiley   +1 more source

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, Volume 12, Issue 12, December 2022., 2022
Myoglobin (MB) is highly expressed in brown adipose tissue (BAT), its expression level increases with adipocyte differentiation and it is temperature dependently regulated in vivo. Expression levels of MB in brown and white adipocytes control mitochondrial respiratory capacity and increase acute response to adrenergic signalling and lipolysis.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
wiley   +1 more source

Biphasic Role of Calcium in Mouse Sperm Capacitation Signaling Pathways [PDF]

, 2015
Mammalian sperm acquire fertilizing ability in the female tract in a process known as capacitation. At the molecular level, capacitation is associated with up-regulation of a cAMP-dependent pathway, changes in intracellular pH, intracellular Ca2+, and an
Alvau, Antonio, Darszon, Alberto, Escoffier, Jessica, García Vázquez, Francisco A., Krapf, Dario, Navarrete, Felipe A., Salicioni, Ana M., Sánchez Cárdenas, Claudia, Visconti, Pablo E.   +8 more
core   +1 more source

Novel approach for the detection of the vestiges of testicular mRNA splicing errors in mature spermatozoa of Japanese Black bulls.

PLoS ONE, 2013
There is a serious problem with the reduction of male reproductive performance of the livestock in the world. We have a hypothesis that the splicing error-caused derivation of aberrant sperm motility-related proteins may be one of its causal factors.
Taichi Noda, Mitsuhiro Sakase, Moriyuki Fukushima, Hiroshi Harayama   +3 more
doaj   +1 more source

Aldosterone signaling and soluble adenylyl cyclase—A nexus for the kidney and vascular endothelium [PDF]

, 2014
The steroid hormone aldosterone regulates the reabsorption of water and ions in the kidney and plays a central role in blood pressure regulation and homeostasis.
Brand, Eva, Brand, Stefan-Martin, Schmitz, Boris   +2 more
core   +1 more source

Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase

Interface Focus, 2021
Soluble adenylyl cyclase (sAC; ADCY10) is a bicarbonate (HCO3−)-regulated enzyme responsible for the generation of cyclic adenosine monophosphate (cAMP).
Tommaso Rossetti, S. Jackvony, J. Buck, L. Levin   +3 more
semanticscholar   +1 more source

Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition [PDF]

, 2010
In birds, as in mammals, one pair of chromosomes differs between the sexes. In birds, males are ZZ and females ZW. In mammals, males are XY and females XX.
BT Lahn, Colin Kremitzki, DA Benson, DA Filatov, Daniel W. Bellott, David C. Page, DL Wheeler, Elaine R. Mardis, ES Lander, F Grützner, GJ Wyckoff, GM Saifl, H Skaletsky, HA Wichman, Helen Skaletsky, HJ Muller, I Korf, I Nanda, I Nanda, International Chicken Genome Sequen, JJ Smith, JW Wallis, Laura G. Brown, LJL Handley, M Kasahara, M Morisson, M Nicolas, MJ Scanlan, MT Ross, P Flicek, PE Boardman, R Saxena, Richard K. Wilson, S Griffiths-Jones, S Ohno, SF Altschul, Steve Rozen, T Ezaz, T Hori, T Kuroda-Kawaguchi, Tatyana Pyntikova, Tina Graves, TJ Hubbard, TM Lowe, W Rens, Wesley C. Warren, WJ Kent, WJ Swanson, WR Rice   +48 more
core   +2 more sources

Molecular, Enzymatic, and Cellular Characterization of Soluble Adenylyl Cyclase From Aquatic Animals. [PDF]

, 2018
The enzyme soluble adenylyl cyclase (sAC) is the most recently identified source of the messenger molecule cyclic adenosine monophosphate. sAC is evolutionarily conserved from cyanobacteria to human, is directly stimulated by [Formula: see text] ions ...
Acin-Perez, Barott, Barott, Barott, Beltrán, Berthelot, Bitterman, Bordeaux, Braun, Braun, Braun, Buck, Camacho Londoño, Chaloupka, Chen, Chen, Cooper, De Rasmo, Di Benedetto, Elliott, Farrell, Geng, Goldberg, Gordeladze, Hess, Hrdlickova, Jaiswal, Kobayashi, Leparc, Levin, Litvin, Magro, Neer, Neer, Nomura, Nomura, Ramos-Espiritu, Roa, Roa, Roa, Salem, Salomon, Schwencke, Steegborn, Steegborn, Stessin, Structural Genomics Consortium, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Wilson, Yeo, Zaccolo, Zippin, Zippin, Zippin, Zippin   +58 more
core   +2 more sources