Results 51 to 60 of about 978 (151)

Aldosterone signaling and soluble adenylyl cyclase—A nexus for the kidney and vascular endothelium [PDF]

, 2014
The steroid hormone aldosterone regulates the reabsorption of water and ions in the kidney and plays a central role in blood pressure regulation and homeostasis.
Brand, Eva, Brand, Stefan-Martin, Schmitz, Boris   +2 more
core   +1 more source

Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition [PDF]

, 2010
In birds, as in mammals, one pair of chromosomes differs between the sexes. In birds, males are ZZ and females ZW. In mammals, males are XY and females XX.
BT Lahn, Colin Kremitzki, DA Benson, DA Filatov, Daniel W. Bellott, David C. Page, DL Wheeler, Elaine R. Mardis, ES Lander, F Grützner, GJ Wyckoff, GM Saifl, H Skaletsky, HA Wichman, Helen Skaletsky, HJ Muller, I Korf, I Nanda, I Nanda, International Chicken Genome Sequen, JJ Smith, JW Wallis, Laura G. Brown, LJL Handley, M Kasahara, M Morisson, M Nicolas, MJ Scanlan, MT Ross, P Flicek, PE Boardman, R Saxena, Richard K. Wilson, S Griffiths-Jones, S Ohno, SF Altschul, Steve Rozen, T Ezaz, T Hori, T Kuroda-Kawaguchi, Tatyana Pyntikova, Tina Graves, TJ Hubbard, TM Lowe, W Rens, Wesley C. Warren, WJ Kent, WJ Swanson, WR Rice   +48 more
core   +2 more sources

Maternal Transmission Ratio Distortion in two Iberian pig varieties [PDF]

, 2020
[EN] Transmission ratio distortion (TRD) is defined as the allele transmission deviation from the heterozygous parent to the offspring from the expected Mendelian genotypic frequencies. Although TRD can be a confounding factor in genetic mapping studies,
Casellas, Joaquim, Ibáñez-Escriche, Noelia, Martín de Hijas-Villalba, Melani, Negro, Sara, Noguera, Jose Luis, Rosas, Juan Pablo, Varona, Luis, Vazquez-Gomez, Marta   +7 more
core   +3 more sources

Molecular, Enzymatic, and Cellular Characterization of Soluble Adenylyl Cyclase From Aquatic Animals. [PDF]

, 2018
The enzyme soluble adenylyl cyclase (sAC) is the most recently identified source of the messenger molecule cyclic adenosine monophosphate. sAC is evolutionarily conserved from cyanobacteria to human, is directly stimulated by [Formula: see text] ions ...
Acin-Perez, Barott, Barott, Barott, Beltrán, Berthelot, Bitterman, Bordeaux, Braun, Braun, Braun, Buck, Camacho Londoño, Chaloupka, Chen, Chen, Cooper, De Rasmo, Di Benedetto, Elliott, Farrell, Geng, Goldberg, Gordeladze, Hess, Hrdlickova, Jaiswal, Kobayashi, Leparc, Levin, Litvin, Magro, Neer, Neer, Nomura, Nomura, Ramos-Espiritu, Roa, Roa, Roa, Salem, Salomon, Schwencke, Steegborn, Steegborn, Stessin, Structural Genomics Consortium, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Wilson, Yeo, Zaccolo, Zippin, Zippin, Zippin, Zippin   +58 more
core   +2 more sources

Genetics and epigenetics of atopic dermatitis: An updated systematic review [PDF]

, 2020
[EN]Background: Atopic dermatitis is a common inflammatory skin disorder that affects up to 15-20% of the population and is characterized by recurrent eczematous lesions with intense itching.
Dávila González, Ignacio Jesús, Estravís Sastre, Miguel, García Sánchez, María Asunción, Isidoro García, María, Martin, Maria J., Sanz Lozano, Catalina Sofía   +5 more
core   +1 more source

Identification of genes for complex diseases using integrated analysis of multiple types of genomic data.

PLoS ONE, 2012
Various types of genomic data (e.g., SNPs and mRNA transcripts) have been employed to identify risk genes for complex diseases. However, the analysis of these data has largely been performed in isolation.
Hongbao Cao, Shufeng Lei, Hong-Wen Deng, Yu-Ping Wang   +3 more
doaj   +1 more source

Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics [PDF]

, 2016
Mastitis, inflammation of the mammary gland, is the most common and costly disease of dairy cattle in the western world. It is primarily caused by bacteria, with Streptococcus uberis as one of the most prevalent causative agents.
Burchmore, Richard, Eckersall, Peter, Herzyk, Pawel, McLaughlin, Mark, Mcneilly, Tom, Mudaliar, Manikhandan, Tassi, Riccardo, Thomas, Funmilola, Weidt, Stefan, Wilson, David, Zadoks, Ruth   +10 more
core   +1 more source

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.

Journal of Clinical Investigation, 2020
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated ...
M. Siraj, D. Mundil, Sanja Beca, A. Momen, E. Shikatani, T. Afroze, Xuetao Sun, Y. Liu, S. Ghaffari, Warren L. Lee, M. Wheeler, G. Keller, P. Backx, M. Husain   +13 more
semanticscholar   +1 more source

Human Sperm Remain Motile After a Temporary Energy Restriction but do Not Undergo Capacitation-Related Events [PDF]

, 2021
To acquire fertilization competence, mammalian sperm must undergo several biochemical and physiological modifications known as capacitation. Despite its relevance, the metabolic pathways that regulate the capacitation-related events, including the ...
Buffone, Mariano G., Gervasi, María G., Krapf, Darío, Luque, Guillermina M., Marín-Briggiler, Clara I., Mondillo, Carolina, Oscoz-Susino, Natalia, Salicioni, Ana M., Sierra, Jessica M., Visconti, Pablo E.   +9 more
core   +3 more sources

Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa

Zoological Letters, 2019
Background CatSper is a sperm-specific calcium ion (Ca2+) channel, which regulates sperm flagellar beating by tuning cytoplasmic Ca2+ concentrations. Although this Ca2+ channel is essential for mammalian fertilization, recent bioinformatics analyses have
Francisco Romero, Takuya Nishigaki
doaj   +1 more source