Results 61 to 70 of about 1,033 (153)

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]

, 2018
Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun, Ellisman, Mark H, Jeong, Seung Won, Ju, Won-Kyu, Kim, Keun-Young, Nam, Hye Seung, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +8 more
core   +2 more sources

Genetics and epigenetics of atopic dermatitis: An updated systematic review [PDF]

, 2020
[EN]Background: Atopic dermatitis is a common inflammatory skin disorder that affects up to 15-20% of the population and is characterized by recurrent eczematous lesions with intense itching.
Dávila González, Ignacio Jesús, Estravís Sastre, Miguel, García Sánchez, María Asunción, Isidoro García, María, Martin, Maria J., Sanz Lozano, Catalina Sofía   +5 more
core   +1 more source

Isolated asthenozoospermia: What should we know? A narrative review of literature

UroPrecision, Volume 3, Issue 2, Page 73-86, June 2025.
ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa, Khaled Almekaty, Ahmed Zoeir, Hussein Mamdoh, Ayman Mousa, Mohammed Abou‐elenein, Tarek Gameel, Maged Ragab   +7 more
wiley   +1 more source

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. [PDF]

, 2020
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants ...
Abraham, Jean, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Ashworth, Alan, Auer, Paul L, Auvinen, Päivi, Beckmann, Matthias W, Beesley, Jonathan, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brucker, Sara Y, Burwinkel, Barbara, Børresen-Dale, Anne-Lise, Caldas, Carlos, Canzian, Federico, Chang-Claude, Jenny, Chanock, Stephen J, Chin, Suet-Feung, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Dunn, Janet A, Dunning, Alison M, Dwek, Miriam, Earl, Helena M, Eccles, Diana M, Eliassen, A Heather, Ellberg, Carolina, Escala-Garcia, Maria, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Gago-Dominguez, Manuela, Gapstur, Susan M, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, George, Angela, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Grip, Mervi, Guo, Qi, Guénel, Pascal, Haiman, Christopher A, Hamann, Ute, Harrington, Patricia A, Hiller, Louise, Hooning, Maartje J, Hopper, John L, Howell, Anthony, Huang, Chiun-Sheng, Huang, Guanmengqian, Hunter, David J, Håkansson, Niclas, Jakubowska, Anna, John, Esther M, Kaaks, Rudolf, Kapoor, Pooja Middha, Keeman, Renske, Kitahara, Cari M, Koppert, Linetta B, Kraft, Peter, Kristensen, Vessela N, Lambrechts, Diether, Le Marchand, Loic, Lejbkowicz, Flavio, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martinez, Maria Elena, Maurer, Tabea, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger L, Mulligan, Anna Marie, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan   +99 more
core  

Potential impact of primate‐specific SVA retrotransposons during the evolution of human cognitive function. [PDF]

, 2017
The SVA family of hominid-specific non-LTR retrotransposon comprises the youngest group of transposable elements in the human genome. The propagation of the most ancient SVA subfamily took place about 13.5 million years ago, and the youngest SVA ...
Bubb, VJ, Cetiner, S, Quinn, JP, Savage, A, Schumann, GG, Vasieva, O   +5 more
core   +1 more source

Determination via an Integration Strategy of the Potential Dermal ECM Reconstruction Mechanism by Which the WAW Formula Alleviates Skin Aging

Journal of Cosmetic Dermatology, Volume 24, Issue 4, April 2025.
ABSTRACT Background Traditional Chinese medicine (TCM) treats skin conditions and delays aging using specific formulas. TCM links skin health to internal organ functions: kidney qi deficiency accelerates aging, whereas spleen deficiency leads to dry, loose skin from insufficient qi and blood. The renowned spleen‐tonifying and kidney‐nourishing formula “
Yingying Lin, Yunhee Chang, Yoojae Maeng, Xiaoxing Liu, Xinke Liu, Hong Meng, Fan Yi   +6 more
wiley   +1 more source

Renal transplantation in rare monogenic urinary stone disease – A single-center experience

Indian Journal of Transplantation
Introduction: Monogenic urinary stone disease (MUSD) tends to be more severe with early onset of symptoms and a higher risk of chronic kidney disease than sporadic USD. The literature on the outcome after renal transplant in patients with certain MUSD is
Sabarinath Shanmugam, Narayan Prasad, Dharmendra Bhadauria, Anupma Kaul, Manas Ranjan Patel, Manas Ranjan Behera, Ravi Shankar Kushwaha, Monika Yachha   +7 more
doaj   +1 more source

An observational cohort feasibility study to identify microvesicle and miRNA biomarkers of acute kidney injury following paediatric cardiac surgery [PDF]

, 2018
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Objectives: Micro-RNA, small noncoding RNA fragments involved in gene regulation, and microvesicles ...
JnTala, Maria, Kumar, Tracy, Lotto, Attilio, Mariani, Silvia, Murphy, Gavin, Pais, Paolo, Smallwood, Dawn T., Sullo, Nikol, Westrope, Claire, Wozniak, Marcin   +9 more
core   +1 more source

Human Sperm Remain Motile After a Temporary Energy Restriction but do Not Undergo Capacitation-Related Events [PDF]

, 2021
To acquire fertilization competence, mammalian sperm must undergo several biochemical and physiological modifications known as capacitation. Despite its relevance, the metabolic pathways that regulate the capacitation-related events, including the ...
Buffone, Mariano G., Gervasi, María G., Krapf, Darío, Luque, Guillermina M., Marín-Briggiler, Clara I., Mondillo, Carolina, Oscoz-Susino, Natalia, Salicioni, Ana M., Sierra, Jessica M., Visconti, Pablo E.   +9 more
core   +3 more sources

Patient‐derived xenograft model in cancer: establishment and applications

MedComm, Volume 6, Issue 2, February 2025.
This review presents the establishment and application of patient‐derived xenograft (PDX) models, underscoring their extensive application in various therapeutic strategies including chemotherapy, targeted therapy, delivery systems, combination therapy, antibody–drug conjugates, and radiotherapy.
Ao Gu, Jiatong Li, Meng‐Yao Li, Yingbin Liu   +3 more
wiley   +1 more source