Results 61 to 70 of about 978 (151)

Correlative study on impaired prostaglandin E2 regulation in EAT and maladaptive cardiac remodeling via EPAC2 and ST2 signaling in overweight CVD subjects [PDF]

, 2020
There is recent evidence that the dysfunctional responses of a peculiar visceral fat deposit known as epicardial adipose tissue (EAT) can directly promote cardiac enlargement in the case of obesity.
E. Dozio, E. Micaglio, E. Vianello, F. Bandera, G. Schmitz, J. Lamont, L. Tacchini, M. Froldi, M.M.C. Romanelli   +8 more
core   +1 more source

Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa [PDF]

, 2022
Spermatozoa acquire fertilization potential during passage through a highly specialized region of the extratesticular ductal system known as the epididymis.
Anderson, A.L., Bernstein, I.R., Bromfield, E.G., Dun, M.D., Humphrey, S.J., Mulhall, J.E., Nixon, B., Schjenken, J.E., Skerrett-Byrne, D.A.   +8 more
core   +1 more source

Renal transplantation in rare monogenic urinary stone disease – A single-center experience

Indian Journal of Transplantation
Introduction: Monogenic urinary stone disease (MUSD) tends to be more severe with early onset of symptoms and a higher risk of chronic kidney disease than sporadic USD. The literature on the outcome after renal transplant in patients with certain MUSD is
Sabarinath Shanmugam, Narayan Prasad, Dharmendra Bhadauria, Anupma Kaul, Manas Ranjan Patel, Manas Ranjan Behera, Ravi Shankar Kushwaha, Monika Yachha   +7 more
doaj   +1 more source

Patient‐derived xenograft model in cancer: establishment and applications

MedComm, Volume 6, Issue 2, February 2025.
This review presents the establishment and application of patient‐derived xenograft (PDX) models, underscoring their extensive application in various therapeutic strategies including chemotherapy, targeted therapy, delivery systems, combination therapy, antibody–drug conjugates, and radiotherapy.
Ao Gu, Jiatong Li, Meng‐Yao Li, Yingbin Liu   +3 more
wiley   +1 more source

Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue [PDF]

, 2016
Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes.
Arrigoni, Laura, Brüning, Jens C., Dengjel, Jörn, Duteil, Delphine, Kanouni, Toufike, Kornfeld, Jan-Wilhelm, Lausecker, Franziska, Manke, Thomas, Meret, Michael, Messaddeq, Nadia, Müller, Judith M., Nenseth, Hatice Z., Petroll, Kerstin, Schüle, Roland, Tosic, Milica, Urban, Sylvia, Willmann, Dominica, Zagoriy, Vyacheslav   +17 more
core   +2 more sources

Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration†

Biology of Reproduction, 2020
Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the ...
M. Balbach, M. Fushimi, D. Huggins, C. Steegborn, P. Meinke, L. Levin, J. Buck   +6 more
semanticscholar   +1 more source

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. [PDF]

, 2020
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants ...
Abraham, Jean, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Ashworth, Alan, Auer, Paul L, Auvinen, Päivi, Beckmann, Matthias W, Beesley, Jonathan, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brucker, Sara Y, Burwinkel, Barbara, Børresen-Dale, Anne-Lise, Caldas, Carlos, Canzian, Federico, Chang-Claude, Jenny, Chanock, Stephen J, Chin, Suet-Feung, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Dunn, Janet A, Dunning, Alison M, Dwek, Miriam, Earl, Helena M, Eccles, Diana M, Eliassen, A Heather, Ellberg, Carolina, Escala-Garcia, Maria, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Gago-Dominguez, Manuela, Gapstur, Susan M, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, George, Angela, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Grip, Mervi, Guo, Qi, Guénel, Pascal, Haiman, Christopher A, Hamann, Ute, Harrington, Patricia A, Hiller, Louise, Hooning, Maartje J, Hopper, John L, Howell, Anthony, Huang, Chiun-Sheng, Huang, Guanmengqian, Hunter, David J, Håkansson, Niclas, Jakubowska, Anna, John, Esther M, Kaaks, Rudolf, Kapoor, Pooja Middha, Keeman, Renske, Kitahara, Cari M, Koppert, Linetta B, Kraft, Peter, Kristensen, Vessela N, Lambrechts, Diether, Le Marchand, Loic, Lejbkowicz, Flavio, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martinez, Maria Elena, Maurer, Tabea, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger L, Mulligan, Anna Marie, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan   +99 more
core  

Genetic Testing and FOX News [PDF]

, 2022
Genetic testing is transforming kidney care, arguably with similar impact as the adoption of kidney biopsies in the 1950s. It is incumbent on nephrologists to teach the genetics of kidney disease and the accessibility of genetic testing.
Bichet, Daniel G, Bockenhauer, Detlef
core  

Intracellular Mg2+ concentrations are differentially regulated in the sperm head and mid‐piece in acrosome reaction inducing conditions

The FASEB Journal, Volume 38, Issue 21, 15 November 2024.
Because Mg2+ complexes with ATP, changes in intracellular Mg2+ ([Mg2+]i), monitored with Mag‐520, reflect, in part, ATP levels. Mag‐520 allows the concomitant detection of [Mg2+]i and [Ca2+]i. [Mg2+]i increases under two conditions that reduce ATP: starvation and capacitation. Conversely, nutrient addition to starved sperm decrease Mag‐520 fluorescence.
C. Sánchez‐Cárdenas, J. L. De la Vega‐Beltrán, W. D. Weber, G. Orta, Y. Sánchez‐Guevara, A. Hernández‐Cruz, A. Darszon, P. E. Visconti   +7 more
wiley   +1 more source

The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm [PDF]

, 2016
Sperm capacitation is required for fertilization. At the molecular level, this process is associated with fast activation of protein kinase A. Downstream of this event, capacitating conditions lead to an increase in tyrosine phosphorylation. The identity
Alvau, Antonio, Battistone, Maria Agustina, Cuasnicu, Patricia Sara, Da Ros, Vanina Gabriela, Darszon, Alberto, De la Vega Beltran, José Luis, Gervasi, Maria Gracia, Greer, Peter, Krapf, Diego, Navarrete, Felipe A., Salicioni, Ana María, Sánchez Cárdenas, Claudia, Visconti, Pablo E., Xu, Xinran   +13 more
core   +1 more source