Results 71 to 80 of about 1,033 (153)
Biology of Reproduction, 2020 Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the ...
M. Balbach +6 more
semanticscholar +1 more source
Central role of soluble adenylyl cyclase and cAMP in sperm physiology [PDF]
, 2014 Cyclic adenosine 3′,5′-monophosphate (cAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types.
Buffone, Mariano Gabriel +3 more
core +2 more sources
Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa [PDF]
, 2022 Spermatozoa acquire fertilization potential during passage through a highly specialized region of the extratesticular ductal system known as the epididymis.
Anderson, A.L. +8 more
core +1 more source
The FASEB Journal, Volume 38, Issue 21, 15 November 2024.Because Mg2+ complexes with ATP, changes in intracellular Mg2+ ([Mg2+]i), monitored with Mag‐520, reflect, in part, ATP levels. Mag‐520 allows the concomitant detection of [Mg2+]i and [Ca2+]i. [Mg2+]i increases under two conditions that reduce ATP: starvation and capacitation. Conversely, nutrient addition to starved sperm decrease Mag‐520 fluorescence.
C. Sánchez‐Cárdenas +7 more
wiley +1 more source
David Garbers' Contributions to Chemotaxis Signaling in Sperm
Molecular Reproduction and Development, Volume 91, Issue 10, October 2024.ABSTRACT This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm‐specific, unique Na+/H+ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel ...
U. B. Kaupp, Olivia Kendall
wiley +1 more source
High intensity exercise as a dishabituating stimulus restores counterregulatory responses in recurrently hypoglycemic rodents [PDF]
, 2017 Hypoglycemia is a major adverse effect of insulin therapy for people with type 1 diabetes (T1D). Profound defects in the normal counterregulatory response to hypoglycemia explain the frequency of hypoglycemia occurrence in T1D.
Ashford, Michael L. J. +4 more
core +2 more sources
Andrology, Volume 12, Issue 7, Page 1558-1567, October 2024.Abstract Introduction This manuscript presents non‐hormonal male contraceptive development in the context of mitigating risk to investigators and investors. Objective The manuscript uses examples to illustrate drug development principles to move a project from discovery to development.
Daniel S. Johnston
wiley +1 more source
Correlative study on impaired prostaglandin E2 regulation in EAT and maladaptive cardiac remodeling via EPAC2 and ST2 signaling in overweight CVD subjects [PDF]
, 2020 There is recent evidence that the dysfunctional responses of a peculiar visceral fat deposit known as epicardial adipose tissue (EAT) can directly promote cardiac enlargement in the case of obesity.
E. Dozio +8 more
core +1 more source
Acta Physiologica, Volume 240, Issue 10, October 2024.Abstract Aim To identify the physiological role of the acid‐base sensing enzyme, soluble adenylyl cyclase (sAC), in red blood cells (RBC) of the model teleost fish, rainbow trout. Methods We used: (i) super‐resolution microscopy to determine the subcellular location of sAC protein; (ii) live‐cell imaging of RBC intracellular pH (pHi) with specific sAC ...
Till S. Harter +6 more
wiley +1 more source
A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease [PDF]
, 2013 Celiac disease is a common autoimmune disorder characterized by an intestinal inflammation triggered by gluten, a storage protein found in wheat, rye and barley.
Adamovic, Svetlana +13 more
core +7 more sources