Results 71 to 80 of about 978 (151)

David Garbers' Contributions to Chemotaxis Signaling in Sperm

Molecular Reproduction and Development, Volume 91, Issue 10, October 2024.
ABSTRACT This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm‐specific, unique Na+/H+ exchanger that represents a chimera between a solute carrier (SLC) and an ion channel ...
U. B. Kaupp, Olivia Kendall
wiley   +1 more source

A Novel Gene Required for Male Fertility and Functional CATSPER Channel Formation in Spermatozoa [PDF]

, 2014
Summary Calcium signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility, and the acrosome reaction are all mediated by increases in intracellular Ca2+.
Chung, Jean-Ju, Clapham, David E., Krapivinsky, Grigory, Krapivinsky, Luba, Navarro, Betsy   +4 more
core   +1 more source

Pre‐clinical and early clinical considerations for the development of non‐hormonal contraceptives for men

Andrology, Volume 12, Issue 7, Page 1558-1567, October 2024.
Abstract Introduction This manuscript presents non‐hormonal male contraceptive development in the context of mitigating risk to investigators and investors. Objective The manuscript uses examples to illustrate drug development principles to move a project from discovery to development.
Daniel S. Johnston
wiley   +1 more source

Soluble adenylyl cyclase is an acid‐base sensor in rainbow trout red blood cells that regulates intracellular pH and haemoglobin–oxygen binding

Acta Physiologica, Volume 240, Issue 10, October 2024.
Abstract Aim To identify the physiological role of the acid‐base sensing enzyme, soluble adenylyl cyclase (sAC), in red blood cells (RBC) of the model teleost fish, rainbow trout. Methods We used: (i) super‐resolution microscopy to determine the subcellular location of sAC protein; (ii) live‐cell imaging of RBC intracellular pH (pHi) with specific sAC ...
Till S. Harter, Emma A. Smith, Cristina Salmerón, Angus B. Thies, Bryan Delgado, Rod W. Wilson, Martin Tresguerres   +6 more
wiley   +1 more source

Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains.

, 2019
Inside the female genital tract, mammalian sperm undergo a maturation process called capacitation, which primes the sperm to navigate across the oviduct and fertilize the egg.
Hansen, J., Jikeli, J., Körschen, H., Möglich, A., Raju, D., Rassmann, S., Strünker, T., Stüven, B., Wachten, D.   +8 more
core   +1 more source

Comparison of genetic and epigenetic profiles of periodontitis according to the presence of type 2 diabetes

MedComm, Volume 5, Issue 7, July 2024.
Periodontitis accompanied by type 2 diabetes exhibits significant hypomethylation of Fc gamma receptor‐related genes compared with periodontitis. Periodontitis accompanied by type 2 diabetes shows a notable increase in C>T base substitutions within Fc gamma receptor‐related genes compared with periodontitis.
Junho Kang, Hansong Lee, Ji‐Young Joo, Jae‐Min Song, Hyun‐Joo Kim, Yun Hak Kim, Hae Ryoun Park   +6 more
wiley   +1 more source

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]

, 2018
Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun, Ellisman, Mark H, Jeong, Seung Won, Ju, Won-Kyu, Kim, Keun-Young, Nam, Hye Seung, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +8 more
core   +2 more sources

Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes [PDF]

, 2018
M.P was supported by a Fellowship from the German Research Foundation (DFG). This work received infrastructure support through the DFG Cluster of Excellence “Inflammation at Interfaces” (grants EXC306 and EXC306/2), and was supported by grants (WE2678/
Alan D. Irvine, Ben-Gashir, Charles A. Mein, Claire A. Scott, David A. van Heel, David J. Margolis, David P. Kelsell, Edel A. O’Toole, Gunther, Gururaj, Hansjörg Baurecht, Herty Liany, Jianjun Liu, John E.A. Common, Kimura, Krutmann, Manuela Pigors, Margolis, Mark B.Y. Tang, Michael A. Simpson, Natalija Novak, Nicholas Lench, Niloofar Tabarra, Nutten, Odhiambo, Sajid Malik, Sandilands, Schork, Sebastian Maurer-Stroh, Stephan Weidinger, Vachiranee Limviphuvadh, W.H. Irwin McLean, Wang, Wong, Xuan Fei Colin C. Wong   +34 more
core   +4 more sources

Identification and validation of a novel anoikis‐related prognostic model for prostate cancer

Molecular Genetics &Genomic Medicine, Volume 12, Issue 4, April 2024.
Our study has identified a novel anoikis‐related signature consisting of four genes, which demonstrated significant prognostic value for PCa patients. Our findings suggest that this signature could serve as a valuable tool for predicting patient outcomes and guiding personalized treatment strategies for PCa.
Peipei Zhang, Wenzhi Lv, Yang Luan, Wei Cai, Xiangde Min, Zhaoyan Feng   +5 more
wiley   +1 more source

A novel anoikis‐related prognostic signature associated with prognosis and immune infiltration landscape in lung adenocarcinoma

The Journal of Gene Medicine, Volume 26, Issue 1, January 2024.
Based on anoikis‐related genes, we developed a risk prediction model to provide individualized and precise treatment for lung adenocarcinoma patients. Patients in different risk groups need to be targeted for treatment. Abstract Background One of the most prevalent malignancies in the world is lung adenocarcinoma (LUAD), with a large number of people ...
Yue Liu, Shiqi Hu, Meixin Teng, Yang Qing, Xiao Dong, Linsong Chen, Kaixing Ai   +6 more
wiley   +1 more source