Results 21 to 30 of about 310,034 (252)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Added resistance and seakeeping performance of trimarans in oblique waves [PDF]

Ocean Engineering, 2020
Trimaran added resistance and seakeeping performance in oblique waves with strong nonlinearity are rarely investigated. This paper presents the numerical investigations on them by applying a hybrid method, called the QaleFOAM. This method can simulate a trimaran moving in a large wave field, considering viscous effects and dealing with violent wave ...
Gong, J., Yan, S., Ma, Q., Li, Y.
openaire   +2 more sources

Disentangling astroglial physiology with a realistic cell model in silico [PDF]

, 2018
Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry.
A Araque, A Chvatal, A Grosche, A Panatier, A Verkhratsky, A Volterra, A Wallraff, AM Reeves, B Djukic, BA MacVicar, BS Khakh, C Giaume, C Henneberger, CC Fink, DA Rusakov, DA Rusakov, DA Rusakov, DE Bergles, E Scemes, E Shigetomi, EA Bushong, EA Newman, F Ding, F Oschmann, G Seifert, G Ullah, G Wallach, GG Viola, I Patrushev, J Golowasch, J Grosche, J Schaff, J Sibille, K Hama, K Ogata, K Thurley, K Zheng, K Zheng, KC Chen, KP Lehre, KP Lehre, KY Zheng, LP Savtchenko, LP Savtchenko, M Nedergaard, M Pitta De, M Pitta De, MA Castro Di, MD Haustein, MJ Berridge, ML Hines, ML Hines, MR Witcher, N Bazargani, N Hernjak, N Medvedev, P Kofuji, PX Cao, R Srinivasan, R Ventura, RL Rungta, S Anders, S Sylantyev, T Hofer, T Manninen, TaufiqUrRahman, TW Chen, V Parpura, WN Ross, Z Wang, Z Zhang   +70 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Strength determination for band-loaded thin cylinders [PDF]

, 2018
Cylindrical shells are often subjected to local inward loads normal to the shell that arise over restricted zones. A simple axisymmetric example is that of the ring-loaded cylinder, in which an inward line load around the circumference causes either ...
Doerich, Cornelia, Rotter, J. Michael, Vilnay, Margi   +2 more
core   +4 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Experimental Assessment of Planing Hulls Added Resistance in Regular Waves

Journal of Marine Science and Engineering, 2023
Amid a global effort in reducing the shipping ecologic impact, the study of the particular case of added resistance of high speed vessels cruising in a seaway has been approached by a very limited number of authors. In this study, we provide a comprehensive and systematic assessment of the added resistance of a planing hull in regular waves.
Fabio DE LUCA, Claudio Pensa, Riccardo Pigazzini   +2 more
openaire   +3 more sources

A Comprehensive Overview of the Clinical, Electrophysiological, and Neuroimaging Features of BPAN: Insights From a New Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun, Ozgu Kizek, Sibel Aylin Ugur Iseri, Ibrahim Kamaci, Ayse Deniz Elmali, Pinar Iscen, Berfin Gulkaya Guzel, Gul Yalcin Cakmakli, Bulent Elibol, Berril Donmez, Raif Cakmur, Pinar Topaloglu, Turkish NBIA Study Group, Abdullah Acar, Ahmet Acarer, Arzu Karabay, Asuman Ali, Ayla Barlas, Aysegul Gunduz, Banu Ozen Barut, Baris Baslo, Bilge Kocer, Bilgehan Mus, Birsen Karaman, Burcu Gokce Cokal, Cem Ismail Kucukali, Cenk Akbostanci, Ceyhun Sayman, Cagla Turan, Dilek Ince Gunal, Ebru Bilge Dirik, Ebru Erzurumluoglu, Elif Kocasoy Orhan, Enes Demiryurek, Emrah Yucesan, Ercan Kose, Erdem Tuzun, Esen Saka Topcuoglu, Esra Okuyucu, Fatma Betul Ozdilek, Feriha Ozer, Gencer Genc, Gozde Unal, Gulay Kenangil, Gullu Tarhan, Gunes Kiziltan, Halil Onder, Hamit Genc, Hasmet Hanagasi, Hatice Yuksel, Hulya Apaydin, Koray Kirimtay, Mehmet Guney Senol, Melisa Kilic, Meltem Demirkiran, Mert Karaca, Miray Erdem, Muhammet Bilgehan Mus, Murat Gultekin, Nalan Capan, Nazan Karagoz Sakalli, Nazli Basak, Nihan Hande Akcakaya, Ozan Ezer, Ozge Uygun, Ozge Yilmaz Kuspeci, Ozgur Oztop Cakmak, Pervin Iseri, Petek Ballar Kirmizibayrak, Pinar Elkoca, Recep Alp, Remzi Yigiter, Rezzak Yilmaz, Sadika Ozdemir, Selda Keskin, Selen Ilhan Alp, Selen Soylu, Serdar Ceylaner, Serhat Ozkan, Sevda Erer Ozbek, Sevgin Gundogan, Sevil Yasufli, Sezin Alpaydin Baslo, Sibel Ertan, Sultan Cagirici, Seyma Aykac, Vuslat Yilmaz, Yaprak Secil, Yasar Kutukcu, Yeliz Ciftci, Yesim Sucullu Karadag, Yildiz Değirmenci, Zeliha Matur, Nerses Bebek, Murat Emre, Zuhal Yapici   +95 more
wiley   +1 more source

Synapse elimination and learning rules co-regulated by MHC class I H2-Db. [PDF]

, 2014
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC)
Adelson, Jaimie, Brott, Barbara, Cheng, Sarah, Datwani, Akash, Feller, Marla, Kirkby, Lowry, Lee, Hanmi, Shatz, Carla   +7 more
core   +3 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source