Results 71 to 80 of about 604,420 (291)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

A Theory of Natural Addiction [PDF]

, 2007
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Ainslie, Atkinson, Attila Tasnádi, Baldwin, Baron-Cohen, Becker, Becker, Bergstrom, Blass, Blass, Blass, Bodnar, Booth, Brick, Camerer, Camerer, Campbell, Carson-DeWitt, Chiara, Cohen, Colantuoni, Cooper, Cooper, Cummings, Deth, Drewnowski, Dudley, Dum, Fantino, Fehr, Foster, Gilbertson, Gillberg, Gosnell, Griffiths, Grossman, Gruber, Gul, Harrigan, Headlee, Hirshleifer, Hirshleifer, Holtzman, Jaffe, Kahneman, Kalat, Kavaliers, Kavaliers, Killian, Laibson, Laibson, Leboyer, Leboyer, Loewenstein, Martin, McKim, Mello, Mercer, Morley, Mucha, Mucha, Nelson, Nesse, Nesse, Orphanides, Orphanides, Ostrowski, Parfitt, Pert, Pomerleau, Raiten, Raven, Robson, Rogers, Rudski, Samuelson, Sanger, Savage, Schuckit, Si, Simon, Simpkins, Smith, Sozou, Spanagel, Sullivan, Sullivan, ter Riet, Terenius, Trenton G. Smith, van Ree, van Ree, van Ree, Waeltl, Weeks, Weeks, Weiss, Williams, Yamamoto, Yeomans, Yeomans, Yeomans, Zigmond   +102 more
core   +1 more source

Recent Methods for Measuring Dopamine D3 receptor Occupancy In Vivo: Importance for Drug Development

Frontiers in Pharmacology, 2014
There is considerable interest in developing highly selective dopamine D3 receptor ligands for a variety of mental health disorders. Dopamine D3 receptors have been implicated in Parkinson’s Disease, schizophrenia, anxiety, depression, and substance use ...
Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Alan eWilson, Alan eWilson, Alan eWilson, Ariel eGraff, Ariel eGraff, Ariel eGraff, Isabelle eBoileau, Isabelle eBoileau, Isabelle eBoileau, Isabelle eBoileau, Patricia eDi Ciano   +17 more
doaj   +1 more source

A community-driven and evidence-based approach to developing mental wellness strategies in First Nations: a program protocol

Research Involvement and Engagement, 2020
Background Mental health, substance use/addiction and violence (MSV) are important issues affecting the well-being of Indigenous People in Canada. This paper outlines the protocol for a research-to-action program called the Mental Wellness Program (MWP).
Melody Morton Ninomiya, Ningwakwe (Priscilla) George, Julie George, Renee Linklater, Julie Bull, Sara Plain, Kathryn Graham, Sharon Bernards, Laura Peach, Vicky Stergiopoulos, Paul Kurdyak, Gerald McKinley, Peter Donnelly, Samantha Wells   +13 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Prevalence and predictors of video game addiction: a study based on a national representative sample of gamers [PDF]

, 2015
Video gaming has become a popular leisure activity in many parts of the world, and an increasing number of empirical studies examine the small minority that appears to develop problems as a result of excessive gaming.
C Hagquist, Charlotte Thoresen Wittek, CJ Ferguson, CS Andreassen, CS Peters, D Bhugra, D Williams, D Williams, Daniel Hanss, DL King, DL King, DL King, EJ Kim, F Rehbein, GS Brunborg, GS Brunborg, H Choo, H Cole, H Pontes, Helge Molde, HG Wenzel, HR Eriksen, IBM Corp Released, JP Charlton, JS Lemmens, JS Wiggins, K Kroenke, L Elliot, M Algeria, Mark D. Griffiths, MB Donellan, MD Griffiths, MD Griffiths, PT Costa, RA Mentzoni, RL Thorndike, Rune Aune Mentzoni, Ståle Pallesen, Turi Reiten Finserås, Y Takata   +39 more
core   +1 more source

What makes mental health and substance use services youth friendly? A scoping review of literature

BMC Health Services Research, 2019
Background There are increasing calls to make mental health and substance use services youth friendly, with hopes of improving service uptake, engagement and satisfaction. However, youth-friendliness in this area has not been clearly defined and there is
Lisa D. Hawke, Kamna Mehra, Cara Settipani, Jaqueline Relihan, Karleigh Darnay, Gloria Chaim, Joanna Henderson   +6 more
doaj   +1 more source

Targeting glutamine addiction in meningioma [PDF]

, 2022
Anh Tran
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source