Results 61 to 70 of about 420,137 (309)

The dual role dilemma of liver transplantation health care professionals

BMC Medical Ethics, 2023
Background Similar to many other countries, in Germany patients with alcohol-related liver disease are obliged to prove their abstinence before being accepted on a waitlist for liver transplantation.
Annette Binder, Julia Fenchel, Immanuel Lang, Anil Batra   +3 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Associations between happiness with social factors and opioid agonist therapy among people who inject drugs

Scientific Reports
The level of happiness is low among patients with chronic mental or physical disorders. However, happiness and its association to sociodemographic and clinical factors remain unknown among patients with opioid use disorder (OUD) and people who inject ...
Clara Lucas Guerra, Jørn Henrik Vold, Christer Frode Aas, Fatemeh Chalabianloo, Else-Marie Løberg, Kjell Arne Johansson, Lars Thore Fadnes   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sex Addiction: the Chicken-and-Egg Dilemma of Diagnosis [PDF]

, 2013
In May 2013, the American Psychiatric Association will release the next version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Interestingly, sex addiction, despite significant attention from mainstream media, will be omitted from ...
Berry, MD
core  

Experiences with healthy eating among individuals with opioid dependence: insights from a dietary assessment

BMC Nutrition
Background People with substance use disorders often have unhealthy diets, including a limited intake of fruits and vegetables. Additionally, individuals with substance use disorders experience a significantly higher burden of physical and mental health ...
Mohammed Khalid Al-Shibli, Lars Thore Fadnes, Hege Berg Henriksen, Elaheh Javadi Arjmand, Lise Margrete Thomassen, Torgeir Gilje Lid, Siv-Elin Leirvåg Carlsen   +6 more
doaj   +1 more source

Recent Methods for Measuring Dopamine D3 receptor Occupancy In Vivo: Importance for Drug Development

Frontiers in Pharmacology, 2014
There is considerable interest in developing highly selective dopamine D3 receptor ligands for a variety of mental health disorders. Dopamine D3 receptors have been implicated in Parkinson’s Disease, schizophrenia, anxiety, depression, and substance use ...
Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Bernard eLe Foll, Alan eWilson, Alan eWilson, Alan eWilson, Ariel eGraff, Ariel eGraff, Ariel eGraff, Isabelle eBoileau, Isabelle eBoileau, Isabelle eBoileau, Isabelle eBoileau, Patricia eDi Ciano   +17 more
doaj   +1 more source