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Research Involvement and Engagement, 2020 Background Mental health, substance use/addiction and violence (MSV) are important issues affecting the well-being of Indigenous People in Canada. This paper outlines the protocol for a research-to-action program called the Mental Wellness Program (MWP).
Melody Morton Ninomiya +13 more
doaj +1 more source
Substance Abuse Treatment, Prevention, and Policy, 2021 Background Continuous use of amphetamines, alcohol, benzodiazepines, cannabis, cocaine, or opioids contributes to health impairments, increased morbidity, and overdose deaths among patients with substance use disorders (SUDs).
Jørn Henrik Vold +5 more
doaj +1 more source
Hijacking translation in addiction. [PDF]
, 2016 Two studies suggest that the reduced activity of a translation initiation factor called eIF2α might be partly responsible for the increased risk of drug addiction seen in ...
Izquierdo, Alicia, Silva, Alcino J
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
BMC NutritionBackground People with substance use disorders often have unhealthy diets, including a limited intake of fruits and vegetables. Additionally, individuals with substance use disorders experience a significantly higher burden of physical and mental health ...
Mohammed Khalid Al-Shibli +6 more
doaj +1 more source
A longitudinal study for the empirical validation of an etiopathogenetic model of internet addiction in adolescence based on early emotion regulation [PDF]
, 2014 Several etiopathogenetic models have been conceptualized for the onset of Internet Addiction (IA). However, no study had evaluated the possible predictive efect of early emotion regulation strategies on the development of IA in adolescence.
Cimino, Silvia, Cerniglia, Luca
core +4 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Substance Abuse Treatment, Prevention, and PolicyBackground Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population.
Karl Trygve Druckrey-Fiskaaen +7 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source