Results 81 to 90 of about 474,753 (298)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Liver stiffness and associated risk factors among people with a history of injecting drugs: a prospective cohort study

Substance Abuse Treatment, Prevention, and Policy
Background Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population.
Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Håvard Midgard, Olav Dalgard, Rafael Alexander Leiva, Lars T. Fadnes, for the INTRO-HCV Study Group   +7 more
doaj   +1 more source

What makes mental health and substance use services youth friendly? A scoping review of literature

BMC Health Services Research, 2019
Background There are increasing calls to make mental health and substance use services youth friendly, with hopes of improving service uptake, engagement and satisfaction. However, youth-friendliness in this area has not been clearly defined and there is
Lisa D. Hawke, Kamna Mehra, Cara Settipani, Jaqueline Relihan, Karleigh Darnay, Gloria Chaim, Joanna Henderson   +6 more
doaj   +1 more source

Depression, anxiety, and smartphone addiction in university students- A cross sectional study

PLoS ONE, 2017
Objectives The study aims to assess prevalence of smartphone addiction symptoms, and to ascertain whether depression or anxiety, independently, contributes to smartphone addiction level among a sample of Lebanese university students, while adjusting ...
Jocelyne Matar Boumosleh, D. Jaalouk
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Peer involvement and cross-sector efforts in establishing integrated treatment of hepatitis C virus infection for people with substance use disorders: experiences from Norway

Substance Abuse Treatment, Prevention, and Policy, 2019
Background For people with opioid dependence in Norway, chronic hepatitis C virus (HCV) infections contribute to high mortality and high morbidity. Around 50% of patients in medically assisted rehabilitation (MAR) have been shown to have HCV, and the ...
Ole Jørgen Lygren, Ronny Bjørnestad, Else-Marie Løberg, Martine Lepsøy Bonnier, Vibeke Bråthen Buljovcic, Kjell Arne Johansson, Lars T. Fadnes, for the INTRO-HCV Study Group   +7 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Integrated exercise program in opioid agonist therapy clinics and effect on psychological distress: study protocol for a randomized controlled trial (BAReAktiv)

Trials
Background Substance use disorder is associated with unhealthy lifestyle choices, resulting in adverse social and health consequences. People with opioid use disorder receiving opioid agonist therapy, in particular, have high morbidity and reduced ...
Einar Furulund, Tesfaye Madebo, Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Mette Hegland Nordbotn, Eivin Dahl, Sindre M. Dyrstad, Torgeir Gilje Lid, Lars T. Fadnes, for the ATLAS4LAR study group   +9 more
doaj   +1 more source

Myelin-associated Glycoprotein gene and brain morphometry in schizophrenia

Frontiers in Psychiatry, 2012
Myelin and oligodendrocyte disruption may be a core feature of schizophrenia pathophysiology. The purpose of the present study was to localize the effects of previously identified risk variants in the myelin associated glycoprotein gene on brain ...
Daniel eFelsky, Aristotle N Voineskos, Jason P Lerch, Arash eNazeri, Arash eNazeri, Sajid A Shaikh, Tarek K Rajji, Benoit H Mulsant, James eKennedy   +8 more
doaj   +1 more source

Effects of Oxytocin on Drug Addiction and Its Relationship to Prosocial Behavior [PDF]

, 2023

openalex   +1 more source