Results 81 to 90 of about 960,477 (390)
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
core
Cocaine Addiction as a Homeostatic Reinforcement Learning Disorder [PDF]
, 2017 Drug addiction implicates both reward learning and homeostatic regulation mechanisms of the brain. This has stimulated 2 partially successful theoretical perspectives on addiction.
Durand, A. +4 more
core +1 more source
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Pharmacological Reviews, 2020 Compulsive drug seeking that is associated with addiction is hypothesized to follow a heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation) and three domains of dysfunction ...
G. Koob
semanticscholar +1 more source
Frontiers in Psychiatry, 2013 Abstract This chapter addresses two main questions about the ethics of addiction: 1. What moral attitudes should addicts have toward themselves? Does it make sense for addicts to experience shame and guilt, to feel responsible for their addiction and what they do because they are addicts? 2.
openaire +3 more sources
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Kicking the oil addiction [PDF]
, 2010 Few people were left unaffected by the soaring oil prices of summer 2008. Motorists were the hardest hit as the price at the pumps reached an all time high, but nobody could avoid paying more for their food as higher transport costs were passed on from ...
Andelman, David +2 more
core +1 more source
Scientific ReportsThe level of happiness is low among patients with chronic mental or physical disorders. However, happiness and its association to sociodemographic and clinical factors remain unknown among patients with opioid use disorder (OUD) and people who inject ...
Clara Lucas Guerra +6 more
doaj +1 more source
Recent Methods for Measuring Dopamine D3 receptor Occupancy In Vivo: Importance for Drug Development
Frontiers in Pharmacology, 2014 There is considerable interest in developing highly selective dopamine D3 receptor ligands for a variety of mental health disorders. Dopamine D3 receptors have been implicated in Parkinson’s Disease, schizophrenia, anxiety, depression, and substance use ...
Bernard eLe Foll +17 more
doaj +1 more source
Research Involvement and Engagement, 2020 Background Mental health, substance use/addiction and violence (MSV) are important issues affecting the well-being of Indigenous People in Canada. This paper outlines the protocol for a research-to-action program called the Mental Wellness Program (MWP).
Melody Morton Ninomiya +13 more
doaj +1 more source