Results 71 to 80 of about 5,779,386 (384)

Genetics of addictive behavior: the example of nicotine dependence

Dialogues in Clinical Neuroscience, 2017
The majority of addictive disorders have a significant heritability—roughly around 50%. Surprisingly, the most convincing association (a nicotinic acetylcholine receptor CHRNA5-A3-B4 gene cluster in nicotine dependence), with a unique attributable risk ...
P. Gorwood, Y. Le Strat, N. Ramoz
semanticscholar   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Conñerning Theoretical Grounds of Addictive Behavior [PDF]

, 2015
статті розкрито актуальність досліджуваного феномену. Дано визначення адиктивної поведінки, розкрито її форми, причини виникнення та фази розвитку. The actuality of research phenomenon is discovered in this article.
Ostapiovska, Tetiana P., Ostapiovskyi, Ihor Ye., Остапйовська, Тетяна Петрівна, Остапйовський, Ігор Євгенович   +3 more
core  

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Introduction to Behavioral Addictions [PDF]

The American Journal of Drug and Alcohol Abuse, 2010
Several behaviors, besides psychoactive substance ingestion, produce short-term reward that may engender persistent behavior, despite knowledge of adverse consequences, i.e., diminished control over the behavior. These disorders have historically been conceptualized in several ways. One view posits these disorders as lying along an impulsive-compulsive
Jon E, Grant, Marc N, Potenza, Aviv, Weinstein, David A, Gorelick   +3 more
openaire   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Types and Forms of Addictive Behavior of Law Enforcement Employees

Психология и право, 2019
The article discusses types and forms of an addictive behavior of law enforcement officers (in terms of employees of internal affairs bodies) in conjunction with individual psychological characteristics.
Chernyshova E.V., Suslova V.R.
doaj   +1 more source

Relationship between Food Addictive Behavior and Physical Activity in College-Aged Students

, 2017
Background: Food addiction is believed to play a role in the development of obesity. Acute exercise has been associated with reduced cravings for addictive substances.
S. Bailey, Carlie Huberman, R. Bryant, Stephen Van Rij, Elizabeth K. Bailey   +4 more
semanticscholar   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Peningkatan Self Compassion Untuk Mereduksi Perilaku Adiktif Pengguna Sosial Media Bagi Siswa SMP

Indonesian Journal of Learning Education and Counseling, 2020
The research aims to describe the process of counseling services on improving self-compassion of students in Surabaya Private Junior High Schools who have problems with addictive behaviors using sophisticated technology especially the social media ...
Agus Rizal, Budi Purwoko, Retno Tri Hariastuti   +2 more
doaj   +1 more source