Results 51 to 60 of about 159,113 (296)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

God and the Machine: A Correlational Study on Mobile Phone Dependence, Religious Coping, and Mental Health [PDF]

, 2020
Research on the various effects of mobile phones did not begin to be published until after they had already been integrated into society. To date, the results of various studies looking into the relationship between mobile phone use and mental health ...
Bolme, Rachel
core   +1 more source

The Bergen Shopping Addiction Scale: reliability and validity of a brief screening test [PDF]

, 2015
Although excessive and compulsive shopping has been increasingly placed within the behavioral addiction paradigm in recent years, items in existing screens arguably do not assess the core criteria and components of addiction.
Aboujaoude, Aboujaoude, Albrecht, American Psychiatric Association, American Psychiatric Association, Andreassen, Andreassen, Andreassen, Andreassen, Balabanis, Bjelland, Black, Brown, Byrne, Chambers, Cheung, Christo, Costa, Costa, Davenport, DeSarbo, Dittmar, Donnellan, Faber, Gosling, Griffiths, Griffiths, Harnish, Hartston, Hill, Hu, Huang, Koran, Koronczai, Kraepelin, Lemmens, Lieb, MacKinnon, MacLaren, Manolis, Maraz, Maraz, McQueen, Mikolajczak-Degrauwe, Mowen, Müller, Nunnally, Otero-López, O’Brien, Pettit, Piquet-Pessôa, Podsakoff, Potenza, Raab, Rick, Ridgway, Roberts, Roberts, Rodrigues-Villarino, Rosenberg, Scherhorn, Sussman, Thompson, Valence, Verplanken, Wang, Weinstein, Widyanto, Wiggins, Winter, Workman, Zigmond   +71 more
core   +3 more sources

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Types and Forms of Addictive Behavior of Law Enforcement Employees

Психология и право, 2019
The article discusses types and forms of an addictive behavior of law enforcement officers (in terms of employees of internal affairs bodies) in conjunction with individual psychological characteristics.
Chernyshova E.V., Suslova V.R.
doaj   +1 more source

Changes of consultation-liaison psychiatry practice in Italian general hospitals: A comparative 20-year multicenter study

Frontiers in Psychiatry, 2022
IntroductionConducted under the auspices of the Italian Society of Consultation Liaison Psychiatry (SIPC) the aim of this study was to describe the characteristics of Consultation Liaison Psychiatry (CLP) activity in Italy (SIPC-2—2018) over the past 20 ...
Luigi Zerbinati, Luigi Zerbinati, Laura Palagini, Laura Palagini, Matteo Balestrieri, Martino Belvederi Murri, Martino Belvederi Murri, Rosangela Caruso, Rosangela Caruso, Armando D’Agostino, Armando D’Agostino, Maria Ferrara, Maria Ferrara, Silvia Ferrari, Silvia Ferrari, Antonino Minervino, Paolo Milia, Maria Giulia Nanni, Maria Giulia Nanni, Stefano Pini, Pierluigi Politi, Matteo Porcellana, Matteo Rocchetti, Ines Taddei, Tommaso Toffanin, Tommaso Toffanin, Luigi Grassi, Luigi Grassi, Italian Society of Consultation-Liaison Psychiatry, Jessica Bellucci, Jessica Bellucci, Emilio Bergamelli, Victor Attilio Campagna, Melissa Cherubini, Melissa Cherubini, Federica Folesani, Federica Folesani, Marta Gancitano, Marta Gancitano, Francesca Giannetti, Gianluca Giovanna, Benedetta Gullotta, Benedetta Gullotta, Lucia Massa, Giulia Montardi, Giulia Montardi   +45 more
doaj   +1 more source

Introduction to Behavioral Addictions [PDF]

The American Journal of Drug and Alcohol Abuse, 2010
Several behaviors, besides psychoactive substance ingestion, produce short-term reward that may engender persistent behavior, despite knowledge of adverse consequences, i.e., diminished control over the behavior. These disorders have historically been conceptualized in several ways. One view posits these disorders as lying along an impulsive-compulsive
Jon E, Grant, Marc N, Potenza, Aviv, Weinstein, David A, Gorelick   +3 more
openaire   +2 more sources

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Peningkatan Self Compassion Untuk Mereduksi Perilaku Adiktif Pengguna Sosial Media Bagi Siswa SMP

Indonesian Journal of Learning Education and Counseling, 2020
The research aims to describe the process of counseling services on improving self-compassion of students in Surabaya Private Junior High Schools who have problems with addictive behaviors using sophisticated technology especially the social media ...
Agus Rizal, Budi Purwoko, Retno Tri Hariastuti   +2 more
doaj   +1 more source