Results 81 to 90 of about 278,077 (263)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis of thermomechanical stresses in dual compound thick cylinders under asymmetric loads: An analytical and numerical method

Heliyon
This study presents a 2D comprehensive analytical and numerical analysis of the thermomechanical stresses in an unsymmetric dual compound thick cylinder under steady-state conditions.
Palash Das, Md Ashraful Islam, Dipayan Mondal   +2 more
doaj   +1 more source

Jupiter Additive Difference [of the Equation of Anomaly] - Ptolemy's Almagest by Toomer (Gerald J.) (1984) | Type-B (ID n° 361)

, 2021
This is a type B edition: A type-B edition corresponds to a critical edition of several table witnesses: it is based on several different editions, themselves based on tables from different primary sources. A type-B edition can be based on type-A, type-B or type-C editions.
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Additional file 1 of Carboplatin dose calculations for patients with lung cancer: significant dose differences found depending on dosing equation choice

, 2022
Additional file 1.
Akgül, Seçkin, Chan, Bryan A., Manders, Peter M.   +2 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Venus Additive Difference [of the Equation of Anomaly] - Ptolemy's Almagest by Toomer (Gerald J.) (1984) | Type-B (ID n° 373)

, 2021
Source: Ptolemy's Almagest, Toomer (Gerald J ...
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mercury Additive Difference [of the Equation of Anomaly] - Ptolemy's Almagest by Toomer (Gerald J.) (1984) | Type-B (ID n° 379)

, 2021
Source: Ptolemy's Almagest, Toomer (Gerald J ...
openaire   +1 more source