Results 81 to 90 of about 36,200 (257)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Does the Stochastic Specification of the Linear Expenditure System Matter? [PDF]
When 'income' in a system of demand equations is defined as total expenditure, actual expenditure on any commodity must lie between zero and income, or equivalently, budget shares must lie between zero and one.
Prof. Denis Conniffe and John Eakins
core
, 2021 This is a type B edition: A type-B edition corresponds to a critical edition of several table witnesses: it is based on several different editions, themselves based on tables from different primary sources. A type-B edition can be based on type-A, type-B or type-C editions.
openaire +2 more sources
Malaya Journal of Matematik, 2018 In this paper, authors given the generalized Hyers - Ulam stability of the functional equation deriving from additive and quadratic functions$$\sum_{j=1}^n f\left(x_i-\frac{1}{n} \sum_{j=1}^n x_j\right)=\sum_{i=1}^n f\left(x_i\right)-n f\left(\frac{1}{n} \sum_{j=1}^n x_j\right)$$where $n$ is a positive integer with $n \geq 2$ in Fuzzy Banach space via ...
null A. Bodaghi +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Remarks on stochastic Navier-Stokes equations
, 2016 A theory of stochastic Navier-Stokes equations has been developed in recent years. A few basic facts and open problems are recalled, stressing the role and difference between the model with additive and with multiplicative transport noise. In view of the
Franco Flandoli
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source