Results 161 to 170 of about 758,105 (300)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

florez-alberto/mock-fastq-generator: v0.0.1-alpha

<p>A generator of fastQ files based on random numbers and a template sequence.</p ...
Alberto Florez
core   +1 more source

[News Clip: Atom generator]

, 1959
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about the development of an atomic powered ...
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

Morphometric Explanations for Deep Learning Based Neuroimaging Classifiers. [PDF]

Hum Brain Mapp
Arudkar AG, Evans BJE, Sghirripa S, Jenkinson M, Alzheimer's Disease Neuroimaging Initiative.   +4 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Demodulation-Oriented Neural Denoising for Long-Sequence I/Q Wireless Signals in Data-Link Receiver Chains. [PDF]

Sensors (Basel)
Li M, Li Y, Feng Q.
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

A General Framework for Prediction in Generalized Additive Models

, 2020
Smoothing techniques have become one of the most popular modelling approaches in the unidimensional and multidimensional setting. However, out-of-sample prediction in the context of smoothing models is still an open problem that can significantly widen the use of these models in many areas of knowledge.
openaire   +3 more sources

A Stability Atlas for IBSI Radiomics Features Using Synthetic Digital Phantoms, with Proof-of-Concept Physics-Based Normalisation. [PDF]

J Imaging
Yamamoto S.
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source