Results 181 to 190 of about 13,595 (304)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Improving Population Pharmacokinetic Modelling with Artificial Patients using Generative Artificial Intelligence. [PDF]

Pharmacol Res Perspect
Schöning V, Hammann F.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Koopman-von Neumann and Weyl-Wigner Phase-Space Formulation of Inviscid Euler Flows. [PDF]

Entropy (Basel)
Molnar SM, Godfrey JR.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Additive constacyclic codes and the MacWilliams identities over mixed alphabets: MacWilliams identities of additive constacyclic codes

Let $\mathbb{Z}_p$ be the ring of integers modulo a prime integer $p$, where $p-1$ is a quadratic residue modulo $p$. This paper presents the study of constacyclic codes over chain rings $\mathcal{R}=\frac{\mathbb{Z}_p[u]}{\langle u^2\rangle}$ and ...
Singh, Ashutosh, Prakash, Om, Debnath, Indibar, Alhevaz, Abdollah   +3 more
core   +1 more source

Symplectic QSD, LCD, and ACD Codes over a Non-Commutative Non-Unitary Ring of Order Nine. [PDF]

Entropy (Basel)
Manseri S, Solé P, Alahmadi A, Basaffar W.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Residual Generator Functions for Linear Multivariable Process Fault Detection

, 2012
This paper investigates the design of residual generators in order to perform the fault detection task for linear multivariable models with additive faults and disturbances.
S. Simani, Castaldi P., CASTALDI, PAOLO, SIMANI, Silvio   +3 more
core  

Applications of newly defined diamond Pythagorean fuzzy CODAS method via multi-criteria decision-making problems. [PDF]

PLoS One
Khan MB, Cortez MV, Bin-Mohsin B, Ciurdariu L, Zamri N.   +4 more
europepmc   +1 more source