Results 141 to 150 of about 137,861 (305)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

In-situ elimination of β-flecks in additively manufactured Ti-3.5 wt% Fe alloy

Journal of Materials Research and Technology
Meta-stable β titanium alloys that feature excellent mechanical properties are of great interest for a range of engineering applications. In particular, Fe containing titanium alloy is one of the most promising alloy systems because Fe is the most ...
Dongze Chen, Raj Das, Shenglu Lu, Ma Qian, Dong Qiu   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Simulation of additive manufacturing using coupled constitutive and microstructure models

, 2016
The paper describes the application of modeling approaches used in Computational Welding Mechanics (CWM) applicable for simulating Additive Manufacturing (AM).
Lindgren, Lars-Erik,, Lundbäck, Andreas,, Andersson, Joel,, Fisk, Martin,, Pederson, Robert,   +4 more
core   +1 more source

3D designed battery-free wireless origami pressure sensor

Microsystems & Nanoengineering, 2022
Taeil Kim, Amirhossein Hassanpoor Kalhori, Tae-Ho Kim, Chao Bao, Woo Soo Kim   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Topology Optimization of a Milling Cutter Head for Additive Manufacturing

The rapid growth of the machining market and advancements in additive manufacturing (AM) present new opportunities for innovative tool designs. This preliminary study proposes a design for additive manufacturing (DfAM) approach to redesign a milling ...
José Manuel Costa, Bruno Miguel Guimarães, Bruno Rafael Cunha, Daniel Figueiredo, João Marouvo, Ilídio Brito Costa, Manuel Fernando Vieira   +6 more
core   +1 more source

Design and Additive Manufacturing of a Flat Form Tool

, 2023
The focus of this in-depth study is largely on the application of additive manufacturing in the creation of a flat form tool; an integral component utilized in several engineering applications.
Rahman, Shahbaz
core  

Molten metal jetting of pure silver with micro resolution and tailored microstructure

Materials Today Advances
Molten Metal Jetting (MMJ) is emerging as a promising technology in additive manufacturing, enabling precise and high-resolution printing of intricate 3D structures.
Negar Gilani, Nesma T. Aboulkhair, Marco Simonelli, Mark East, Ian A. Ashcroft, Richard J.M. Hague   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source