Results 131 to 140 of about 1,538,268 (308)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Multifunctional composite microgels: From structural design to biomedical applications
Materials Today BioMicrogels, micrometer-sized hydrogel particles, have emerged as versatile platforms for biomedical applications. Recent advances have driven the development of composite microgels that integrate polymers, nanomaterials, and bioactive agents to achieve ...
Yanli Cai +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A Comparative Analysis of the Additive Manufacturing Alternatives for Producing Steel Parts
Companies are increasingly turning to additive manufacturing as the demand for one-off 3D-printed metal parts rises. The differences in available additive manufacturing technologies necessitate considering both cost and externalities to select the most ...
Pourya Pourhejazy +2 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Recent Advances in 3D Printing and Additive Manufacturing Technology
Additive manufacturing (AM) or 3D printing has played a critical role in Industry 4 [...
Thang Q. Tran
core +1 more source
Cyber-Physically controlled Smart Additive Manufacturing system (CPSAM) : Plenary speech
, 2021 This plenary presentation is focused on the coming manufacturing systems for metal additive manufacturing controlled cyber-physically. Cyber-Physically controlled Smart Additive Manufacturing system (CPSAM) is a smart additive manufacturing system for ...
Asnafi, Nader, +2 more
core
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
3D designed battery-free wireless origami pressure sensor
Microsystems & Nanoengineering, 2022 Taeil Kim +4 more
doaj +1 more source
In-situ elimination of β-flecks in additively manufactured Ti-3.5 wt% Fe alloy
Journal of Materials Research and TechnologyMeta-stable β titanium alloys that feature excellent mechanical properties are of great interest for a range of engineering applications. In particular, Fe containing titanium alloy is one of the most promising alloy systems because Fe is the most ...
Dongze Chen +4 more
doaj +1 more source