Results 111 to 120 of about 1,616,356 (309)

A Comparative Analysis of the Additive Manufacturing Alternatives for Producing Steel Parts

Companies are increasingly turning to additive manufacturing as the demand for one-off 3D-printed metal parts rises. The differences in available additive manufacturing technologies necessitate considering both cost and externalities to select the most ...
Pourya Pourhejazy, Wei Deng Solvang, Mathias Sæterbø   +2 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Une méthodologie de conception pour la fabrication additive [PDF]

, 2011
Résumé - Les méthodologies de Design for Assembly et de Design for Manufacturing visent à rendre les produits plus faciles à fabriquer et à assembler en se basant sur les caractéristiques des procédés actuels de fabrication, toutefois ces ...
RODRIGUE, Hugo, CALATORU, Victor, RICHIR, Simon, RIVETTE, Mickaël   +3 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Influence of AlSi10Mg Thermophysical Properties on the Melt Pool Morphology During High-Fidelity Simulation of Laser Powder Bed Fusion

Modelling
Laser powder bed fusion (LPBF) is an advanced additive manufacturing method, but its productivity is relatively low, which limits its application.
Ivan A. Pelevin, Maria V. Bogdanova, Andrey V. Zakirov, Dmitriy D. Zherebtsov, Stanislav V. Chernyshikhin   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The Chinese Knot inspired anisotropic TC4 lattice Structures: Ultra-high specific strength in engineering materials

Materials & Design
Lattice structures possess high specific strength, multi-functionality through innovative structural designs. Here, we proposed an efficient method for the construction of lattice structures by elongating two-dimensional planar patterns along the load ...
Shenghang Xu, Chao Ding, Meng Han, Minghao Huang, Chunnan Song, Chen Chang, Shiqiu Liu, Xin Yang, Huiping Tang   +8 more
doaj   +1 more source

Simulation of additive manufacturing using coupled constitutive and microstructure models

, 2016
The paper describes the application of modeling approaches used in Computational Welding Mechanics (CWM) applicable for simulating Additive Manufacturing (AM).
Lindgren, Lars-Erik,, Lundbäck, Andreas,, Andersson, Joel,, Fisk, Martin,, Pederson, Robert,   +4 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source