Results 91 to 100 of about 137,861 (305)

Additive Manufacturing: Prospects and Diverse Applications

Additive manufacturing (AM), also known as 3D printing, has emerged as a transformative technology in various industries, providing unprecedented design freedom and customized manufacturing solutions.
Zeyuan Li, Minghao Li, Hulong Ruan, Junjun Wang, Lina Chen, Qixing Jia, Chenglong Yu   +6 more
core   +1 more source

Feasibility evaluation of a new lattice for porous surface design in additive manufacturing medical implants under interfacial tensile bonded testing

, 2023
Porous titanium implant surfaces fabricated with suitable porosity and size using additive manufacturing (AM) can enhance bone–implant stability. There is a critical need to understand the biomechanical performance of porous (lattice) type implants to ...
Wang, Yu-Tzu;Chang, Chun-Ming;Liu, Pei-Hsin;Lin, Chun-Li
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Additive manufacturing for product improvement at Red Bull Technology [PDF]

, 2012
In Formula 1 racing, there is a strong motive for reducing component weight and thereby improving efficiency. This paper demonstrates the advantages Additive Manufacturing brings to the production of hydraulic components. The Direct Metal Laser Sintering
Kibble, Kevin A., Gibbons, Gregory John, Cooper, David E., Stanford, Mark   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Patterned magnetic pole configurations in bonded magnets

Scientific Reports
Additive manufacturing of bonded magnets using polymer extrusion, powder bed fusion, and stereolithography is established, but this paper focuses on the laser powder bed method.
Malaya Prasad Behera, Yifan Lv, Sarat Singamneni   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Prediction of Weld Reinforcement Based on Vision Sensing in GMA Additive Manufacturing Process

, 2020
In the gas-metal-arc (GMA) additive manufacturing process, the shape of the molten pool, the temperature field of the workpiece and the heat dissipation conditions change with the increase of cladding layers, which can affect the dimensional accuracy of ...
Rongwei Yu, Jing Han, Zhuang Zhao, Lianfa Bai   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Additive manufacturing and its effect on sustainable design

, 2016
'Sustainability' is an emerging issue that product development engineers must engage with to remain relevant, competitive and, most importantly, responsible.
Kristav, Per,, Diegel, Olaf,, Motte, Damien,, Lund University., Kianian, Babak,   +4 more
core   +1 more source