Results 101 to 110 of about 1,616,356 (309)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

In situ observation and reduction of hot-cracks in laser additive manufacturing

Communications Materials
Cracking during Laser Additive Manufacturing is a problem for many higher-strength aluminium alloys, including AA6061. Here, we used a pulsed laser with ramp-down power modulation to improve the cracking resistance by about 50% compared to the use of a ...
Yunhui Chen, Duyao Zhang, Patrick O’Toole, Dong Qiu, Marc Seibold, Klaus. Schricker, Jean-Pierre Bergmann, Alexander Rack, Mark Easton   +8 more
doaj   +1 more source

The Effect of Post-Heat Treatments on Microstructure and Mechanical Properties of a L-PBF CoCrNi–AlTi Medium-Entropy Alloy

Metals
A CoCrNi-AlTi medium-entropy alloy was fabricated via laser powder bed fusion (L-PBF), and its microstructural evolution and mechanical response during aging at 500–900 °C for 1 h were systematically investigated.
Xiaojing Xiong, Xiaodong Nong, Libin Yu, Xianzhao Meng, Chunjia Mo, Yunjie Bi, Hui Ding   +6 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Electron Beam Additive Manufacturing of SS316L with a Stochastic Scan Strategy: Microstructure, Texture Evolution, and Mechanical Properties

Metals
This study examines the microstructure, crystallographic texture evolution, and mechanical properties of stainless steel 316L fabricated through electron beam melting using a stochastic scan strategy at a preheat temperature of 1123 K.
K. N. Chaithanya Kumar, Shashank Sharma, Madhavan Radhakrishnan, Rohit Randhavan, Krishna Kamlesh Verma, Shelden Dowden, Zane Weldon Hughes, Rajarshi Banerjee, Narendra B. Dahotre   +8 more
doaj   +1 more source

Advanced Insights into Laser-Based Metal Additive Manufacturing: From Microstructural Control to Functional Performance

Laser based metal additive manufacturing has emerged as a transformative solution for producing next-generation metallic components, from architected lattices [...
Rǎzvan Pǎcurar, Petru Berce
core   +1 more source

Cyber-Physically controlled Smart Additive Manufacturing system (CPSAM) : Plenary speech

, 2021
This plenary presentation is focused on the coming manufacturing systems for metal additive manufacturing controlled cyber-physically. Cyber-Physically controlled Smart Additive Manufacturing system (CPSAM) is a smart additive manufacturing system for ...
Asnafi, Nader,, Stroud, Ian, Suh, Suk-Hwan,   +2 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Additive manufacturing and its effect on sustainable design

, 2016
'Sustainability' is an emerging issue that product development engineers must engage with to remain relevant, competitive and, most importantly, responsible.
Kristav, Per,, Diegel, Olaf,, Motte, Damien,, Lund University., Kianian, Babak,   +4 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source