Results 101 to 110 of about 1,538,268 (308)

Recent progress in additive manufacturing of SiC ceramics: fabrication, challenges and solutions

International Journal of Extreme Manufacturing
Silicon carbide (SiC) ceramics are vital high-performance materials for demanding industries, valued for their superior mechanical strength and tunable thermal and electronic properties.
Piao Qu, Muhammad Irfan Hussain, Zeyu Ji, Chongyu Long, Muhammad Hamza, Jiangyi Tang, Paolo Colombo, Zhangwei Chen   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of Recoater Speed on Powder Bed and Part Quality in Powder Bed Fusion of Metals Using a Laser Beam

Metals
The powder bed fusion of metals using a laser beam (PBF-LB/M) is an additive manufacturing process for the direct production of metal parts using powder as a starting material.
Nick Hantke, Tim Robert Brocksieper, Tobias Grimm, Jan T. Sehrt   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Design for Additive Manufacturing : Supporting Intrinsic-Motivated Creativity [PDF]

, 2017
Emotional aspects and designers’ motivations in Design For Additive Manufacturing are rarely studied. Still, as they can influence creative behaviors, it is worth of interest to draw some bases for a relation between designers’ motivations and the field ...
VAYRE, Benjamin, ABED, Stéphane, Stéphane Abed, Carole Bouchard, SEGONDS, Frederic, BOUCHARD, Carole, Frédéric Segonds, Benjamin Vayre, RIAS, Anne Lise, Anne-lise Rias   +9 more
core   +1 more source

The Effect of Post-Heat Treatments on Microstructure and Mechanical Properties of a L-PBF CoCrNi–AlTi Medium-Entropy Alloy

Metals
A CoCrNi-AlTi medium-entropy alloy was fabricated via laser powder bed fusion (L-PBF), and its microstructural evolution and mechanical response during aging at 500–900 °C for 1 h were systematically investigated.
Xiaojing Xiong, Xiaodong Nong, Libin Yu, Xianzhao Meng, Chunjia Mo, Yunjie Bi, Hui Ding   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Prediction of Weld Reinforcement Based on Vision Sensing in GMA Additive Manufacturing Process

, 2020
In the gas-metal-arc (GMA) additive manufacturing process, the shape of the molten pool, the temperature field of the workpiece and the heat dissipation conditions change with the increase of cladding layers, which can affect the dimensional accuracy of ...
Rongwei Yu, Jing Han, Zhuang Zhao, Lianfa Bai   +3 more
core   +1 more source

In situ observation and reduction of hot-cracks in laser additive manufacturing

Communications Materials
Cracking during Laser Additive Manufacturing is a problem for many higher-strength aluminium alloys, including AA6061. Here, we used a pulsed laser with ramp-down power modulation to improve the cracking resistance by about 50% compared to the use of a ...
Yunhui Chen, Duyao Zhang, Patrick O’Toole, Dong Qiu, Marc Seibold, Klaus. Schricker, Jean-Pierre Bergmann, Alexander Rack, Mark Easton   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source