Results 81 to 90 of about 1,616,356 (309)

Effect of fluoride ion cleaning on surface state and properties of Ni3Al-base superalloy IC10

Cailiao gongcheng
After turbine blades are in service， the defect surface oxide film will affect the repair quality of vacuum brazing. By cleaning the IC10 alloy with fluoride ion， the effects of fluoride ion cleaning on the removal of oxide film， the changes of surface ...
ZHOU Zizheng, ZHAO Haisheng, GAO Junjie, SUN Bingbing   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Patterned magnetic pole configurations in bonded magnets

Scientific Reports
Additive manufacturing of bonded magnets using polymer extrusion, powder bed fusion, and stereolithography is established, but this paper focuses on the laser powder bed method.
Malaya Prasad Behera, Yifan Lv, Sarat Singamneni   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Tribological Properties of Additively Manufactured Aluminum Alloy Subjected to Surface Mechanical Attrition Treatment

Lubricants
To improve the surface quality of an aluminum alloy manufactured by additive manufacturing (AM), mechanical attrition treatment (SMAT) has been applied to the as-fabricated surface of the alloy produced by selective laser melting (SLM).
Yong Sun, Congcong Zhao, Huaping Tang, Yunjie Bi   +3 more
doaj   +1 more source

Teaching Design for Additive Manufacturing Through Problem-Based Learning

, 2018
Additive Manufacturing (AM) is a technology that, while removing many of the constraints of traditional manufacturing, imposes some new constraints of its own.
Diegel, Olaf, Nordin, Axel, Olaf Diegel, Axel Nordin, Damien Motte, Motte, Damien, Diegel, Olaf,, Nordin, Axel,, Motte, Damien,, Lund University.   +9 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Impact Damage Behavior of Additively Manufactured Stainless Steel Triply Periodic Minimal Surface-Lattice Composite Sandwich Panels

ES Materials and Manufacturing
This paper tests the low-energy (120 J) drop-weight impact behavior of composite sandwich panels composed of additively manufactured Stainless Steel 316L (SS316L) sheet-based TPMS-lattice cores and fiber-reinforced composite skins.
Aliaa M. Abou-Ali, Chukwugozie J. Ejeh, Wesley J. Cantwell, Imad Barsoum, Shrinivas Bojanampati, Rashid K. Abu Al-Rub   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

An overview of information technology standardization activities related to additive manufacturing [PDF]

, 2019
This is a post-peer-review, pre-copyedit version of an article published in Progress in Additive Manufacturing. The final authenticated version is available online at: https://link.springer.com/article/10.1007%2Fs40964-019-00087-
Lee, BN, Pei, E, Um, J
core   +1 more source