Results 71 to 80 of about 1,538,268 (308)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Compositional criteria to predict columnar to equiaxed transitions in metal additive manufacturing

Nature Communications
Predicting the columnar to equiaxed transition (CET) and grain refinement for additively manufactured alloys from thermodynamic databases has been a long-standing challenge and an ongoing source of discussion.
Ryan Brooke, Duyao Zhang, Dong Qiu, Mark A. Gibson, Mark Easton   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Revisiting Solidification Microstructure Selection Maps in the Frame of Additive Manufacturing [PDF]

, 2020
Understanding microstructural development in additive manufacturing under highly non-equilibrium cooling conditions and the consequent effects on mechanical properties of the final component is critical for accelerating industrial adoption of these ...
Phillion, A.B., Mohammadpour, P., Plotkowski, A.   +2 more
core   +1 more source

Effect of TiB₂ Addition on the Microstructure and Mechanical Properties of Laser-Directed Energy Deposition TiAl Alloy

Metals
The microstructure characteristics of TiAl alloy prepared by laser-directed energy deposition (L-DED) are coarse columnar grains parallel to the building direction, which results in serious mechanical properties and anisotropy and limits its application.
Yancheng Yang, Yi Hu, Hongyan Chen, Yu Li, Jiawei Wang, Xu Cheng, Haibo Tang, Xianzhe Ran, Dong Liu   +8 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Oxidation in wire arc additive manufacturing of aluminium alloys

, 2021
Wire Arc Additive Manufacturing is a near-net-shape machining technology that enables low-cost production of large and customised metal parts. In the present work, oxidation effects in Wire Arc Additive Manufacturing of the aluminium alloy AW4043/AlSi5 ...
Hauser, Tobias,, Reisch, Raven T.,, Breese, Philipp P.,, Nalam, Yogesh,, Bela, Katharina,, Joshi, Kaivalya S.,, Kaplan, Alexander F.H.,, Kamps, Tobias,, Volpp, Joerg,   +8 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Titanium Alloy Fabricated by Additive Manufacturing for Medical Applications: Obtaining, Characterization and Application—Review

, 2023
Metal additive manufacturing (metal-AM) technology has made significant progress in the field of biomedicine in recent years. Originally, it was only used as an innovative resource for prototypes.
Shuai Liu, Yude Liu, Wentian Shi, Hanjie Guo, Xinjie Zhang   +4 more
core   +1 more source

Optimization of Mechanical Properties in Biomedical-Grade Polylactic Acid (PLA) Components Fabricated Via Fuzed Filament Fabrication (FFF)

Advances in Polymer Technology
The growing demand for personalized biomedical devices positions polylactic acid (PLA) as a useful material because it is biodegradable and biocompatible while being easily processed by additive manufacturing.
Sudheer Reddy, Muli Vaibhav Reddy, G. Vamsi Nivas, Abdulfatah Abdu Yusuf, Muhammad Imam Ammarullah   +4 more
doaj   +1 more source