Results 71 to 80 of about 137,861 (305)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effect of TiB₂ Addition on the Microstructure and Mechanical Properties of Laser-Directed Energy Deposition TiAl Alloy

Metals
The microstructure characteristics of TiAl alloy prepared by laser-directed energy deposition (L-DED) are coarse columnar grains parallel to the building direction, which results in serious mechanical properties and anisotropy and limits its application.
Yancheng Yang, Yi Hu, Hongyan Chen, Yu Li, Jiawei Wang, Xu Cheng, Haibo Tang, Xianzhe Ran, Dong Liu   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigation into the Development of an Additive Manufacturing Technique for the Production of Fibre Composite Products

, 2015
The advancements in manufacturing technology over recent years have made Additive Manufacturing, a breakthrough technology in the designing and manufacturing field.
Birkett, M., Shyha, Islam, Bade, L., Birkett, Martin, Bade, Lokesh, Shyha, I., Hackney, Philip, Hackney, P.M.   +7 more
core   +1 more source

Optimization of Mechanical Properties in Biomedical-Grade Polylactic Acid (PLA) Components Fabricated Via Fuzed Filament Fabrication (FFF)

Advances in Polymer Technology
The growing demand for personalized biomedical devices positions polylactic acid (PLA) as a useful material because it is biodegradable and biocompatible while being easily processed by additive manufacturing.
Sudheer Reddy, Muli Vaibhav Reddy, G. Vamsi Nivas, Abdulfatah Abdu Yusuf, Muhammad Imam Ammarullah   +4 more
doaj   +1 more source

On the Ultrasonic Atomization of SS316L Parts Manufactured via Laser Powder Bed Fusion for the Closed-Loop Production

Journal of Manufacturing and Materials Processing
Sustainable feedstock management remains a major challenge in laser beam powder bed fusion (PBF-LB), where conventional reuse strategies are typically limited to sieving and blending rather than full material regeneration.
Olga Bashmakova, Leonid Fedorenko, Andrey Vasilev, Boris Zotov, Andrey Urzhumtsev, Ali Kavousi Sisi, Maria Lyange, Ivan Pelevin, Mikhail Gilvitinov, Ksenia Petukhova, Ekaterina Zinovyeva, Stanislav Chernyshikhin   +11 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Additive Manufacturing Group at Naval Postgraduate School [PDF]

, 2016
Several departments are collaborating as the Additive Manufacturing Group; MOVES Institute, Mechanical and Aerospace Engineering, Energy Academic Group, Space Systems Academic Group and Center for Asymmetric Warfare.
Sadagic, Amela, Brutzman, Don
core