Results 51 to 60 of about 1,538,268 (308)

Additive manufacturing and high performance applications

, 2018
The requirement on life and robustness for aero-engine components poses obstacles to additive manufacturing. It is expected that increasing knowledge about the process and thereby its development together with adaption of existing alloys may improve ...
Lindgren, Lars-Erik,, Lundbäck, Andreas,, Lindgren, Lars-Erik, Lundbӓck, Andreas   +3 more
core   +1 more source

Optimising the manufacturing of a β-Ti alloy produced via direct energy deposition using small dataset machine learning

Scientific Reports
Successful additive manufacturing involves the optimisation of numerous process parameters that significantly influence product quality and manufacturing success.
Ryan Brooke, Dong Qiu, Tu Le, Mark A. Gibson, Duyao Zhang, Mark Easton   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Robust Additive Manufacturing Performance through a Control Oriented Digital Twin

, 2021
The additive manufacturing process control utilizing digital twins is an emerging issue. However, robustness in process performance is still an open aspect, due to uncertainties, e.g., in material properties.
Alexios Papacharalampopoulos, Panagiotis Stavropoulos, George Chryssolouris, Christos K. Michail   +3 more
core   +1 more source

In-loop additive manufacturing constraints for open-walled microstructures [PDF]

, 2021
The derivation and integration of novel in-loop additive manufacturing constraints for open-walled microstructures within a multiscale optimization framework is presented.
Robert Hewson, Santer, matthew, Hewson, Robert, Ryan Murphy, Matthew Santer, Murphy, ryan   +5 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Additive manufacturing as a platform for introducing cyber-physical services

, 2018
Additive manufacturing (AM) is increasingly used for the production of functional components. This process is based on digital design model and can produce customized components with no additional cost (toolless process).
Holmström, Jan, Khajavi, Siavash H., Baumers, Martin   +2 more
core   +1 more source

Non-destructive detection of critical defects in additive manufacturing

Scientific Reports
Non-destructive examination (NDE) based structural integrity assessment of additively manufactured (AM) metallic parts depends on the reliable detection of volumetric defects and the accurate representation of their detrimental features.
Shaharyar Baig, Alireza Jam, Stefano Beretta, Shuai Shao, Nima Shamsaei   +4 more
doaj   +1 more source

A novel experimental approach to exploring process parameters for fabricating support-free horizontal overhangs in LPBF of Inconel 718

Virtual and Physical Prototyping
The design freedom of Laser Powder Bed Fusion (LPBF) components has been confined by the minimum allowable overhang angle of 45°. It remains unclear how to achieve multiple layers of overhang at zero-degree overhang angle, which is the fundamental basis ...
Chun Kit Sit, Yunlong Tang, Louis N. S. Chiu, Samuel C. V. Lim, Yuman Zhu, Aijun Huang   +5 more
doaj   +1 more source

In process monitoring of the thermal profile during solidification in laser directed energy deposition of aluminium

Additive Manufacturing Letters, 2022
The manufacturing of parts in a layer-by-layer fashion in laser based directed energy deposition (L-DED) of wire enables a unique flexibility and freedom of part design, but some technological challenges remain unsolved.
Christian Hagenlocher, Patrick O’Toole, Wei Xu, Milan Brandt, Mark Easton, Andrey Molotnikov   +5 more
doaj   +1 more source