Results 31 to 40 of about 69,943 (255)

In process monitoring of the thermal profile during solidification in laser directed energy deposition of aluminium

Additive Manufacturing Letters, 2022
The manufacturing of parts in a layer-by-layer fashion in laser based directed energy deposition (L-DED) of wire enables a unique flexibility and freedom of part design, but some technological challenges remain unsolved.
Christian Hagenlocher, Patrick O’Toole, Wei Xu, Milan Brandt, Mark Easton, Andrey Molotnikov   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

On the development of twinning-induced plasticity in additively manufactured 316L stainless steel

Additive Manufacturing Letters, 2023
A report on twinning-induced plasticity in 316L stainless steel manufactured by metal additive manufacturing (AM) is presented. A tapered tensile test geometry was used which enabled the investigation of twin formation over a range of strain levels in a ...
D. Della Crociata, I. Maskery, R. Hague, M. Simonelli   +3 more
doaj   +1 more source

Additive manufacturing: the future of manufacturing

Materiali in tehnologije, 2017
Abstract: Additive manufacturing process is an advanced manufacturing method that is used to fabricate prototypes, tooling, as well as functional product. Additive manufacturing process can produce complex part as a single unit object that was not possible with the traditional manufacturing methods.
Adekanye, Adefemi, Mahamood, Rasheedat M., Akinlabi, Esther Titilayo, Owolabi, Moses G.   +3 more
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Non-destructive detection of critical defects in additive manufacturing

Scientific Reports
Non-destructive examination (NDE) based structural integrity assessment of additively manufactured (AM) metallic parts depends on the reliable detection of volumetric defects and the accurate representation of their detrimental features.
Shaharyar Baig, Alireza Jam, Stefano Beretta, Shuai Shao, Nima Shamsaei   +4 more
doaj   +1 more source

A novel experimental approach to exploring process parameters for fabricating support-free horizontal overhangs in LPBF of Inconel 718

Virtual and Physical Prototyping
The design freedom of Laser Powder Bed Fusion (LPBF) components has been confined by the minimum allowable overhang angle of 45°. It remains unclear how to achieve multiple layers of overhang at zero-degree overhang angle, which is the fundamental basis ...
Chun Kit Sit, Yunlong Tang, Louis N. S. Chiu, Samuel C. V. Lim, Yuman Zhu, Aijun Huang   +5 more
doaj   +1 more source

Design and Characterization of 2.5D Nature-Inspired Infill Structures under Out-Plane Quasi-Static Loading Condition

Advances in Materials Science and Engineering, 2023
The 2.5D (2.5-dimensional) structures are acquired to enhance safety and lightweight designs with better energy absorption in the aerospace and automobile sectors. Additive manufacturing (AM), which is practical to build suitable components in industrial
Dara Ashok, M. V. A. Raju Bahubalendruni
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Defect detection by multi-axis infrared process monitoring of laser beam directed energy deposition

Scientific Reports
Laser beam directed energy deposition (DED-LB) is an attractive additive manufacturing technique to produce versatile and complex 3D structures on demand, apply a cladding, or repair local defects.
T. Herzog, M. Brandt, A. Trinchi, A. Sola, C. Hagenlocher, A. Molotnikov   +5 more
doaj   +1 more source