Results 41 to 50 of about 1,616,356 (309)

Additive manufacturing as a platform for introducing cyber-physical services

, 2018
Additive manufacturing (AM) is increasingly used for the production of functional components. This process is based on digital design model and can produce customized components with no additional cost (toolless process).
Holmström, Jan, Khajavi, Siavash H., Baumers, Martin   +2 more
core   +1 more source

In-loop additive manufacturing constraints for open-walled microstructures [PDF]

, 2021
The derivation and integration of novel in-loop additive manufacturing constraints for open-walled microstructures within a multiscale optimization framework is presented.
Robert Hewson, Santer, matthew, Hewson, Robert, Ryan Murphy, Matthew Santer, Murphy, ryan   +5 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Optimising the manufacturing of a β-Ti alloy produced via direct energy deposition using small dataset machine learning

Scientific Reports
Successful additive manufacturing involves the optimisation of numerous process parameters that significantly influence product quality and manufacturing success.
Ryan Brooke, Dong Qiu, Tu Le, Mark A. Gibson, Duyao Zhang, Mark Easton   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

In process monitoring of the thermal profile during solidification in laser directed energy deposition of aluminium

Additive Manufacturing Letters, 2022
The manufacturing of parts in a layer-by-layer fashion in laser based directed energy deposition (L-DED) of wire enables a unique flexibility and freedom of part design, but some technological challenges remain unsolved.
Christian Hagenlocher, Patrick O’Toole, Wei Xu, Milan Brandt, Mark Easton, Andrey Molotnikov   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Non-destructive detection of critical defects in additive manufacturing

Scientific Reports
Non-destructive examination (NDE) based structural integrity assessment of additively manufactured (AM) metallic parts depends on the reliable detection of volumetric defects and the accurate representation of their detrimental features.
Shaharyar Baig, Alireza Jam, Stefano Beretta, Shuai Shao, Nima Shamsaei   +4 more
doaj   +1 more source

A novel experimental approach to exploring process parameters for fabricating support-free horizontal overhangs in LPBF of Inconel 718

Virtual and Physical Prototyping
The design freedom of Laser Powder Bed Fusion (LPBF) components has been confined by the minimum allowable overhang angle of 45°. It remains unclear how to achieve multiple layers of overhang at zero-degree overhang angle, which is the fundamental basis ...
Chun Kit Sit, Yunlong Tang, Louis N. S. Chiu, Samuel C. V. Lim, Yuman Zhu, Aijun Huang   +5 more
doaj   +1 more source

On the development of twinning-induced plasticity in additively manufactured 316L stainless steel

Additive Manufacturing Letters, 2023
A report on twinning-induced plasticity in 316L stainless steel manufactured by metal additive manufacturing (AM) is presented. A tapered tensile test geometry was used which enabled the investigation of twin formation over a range of strain levels in a ...
D. Della Crociata, I. Maskery, R. Hague, M. Simonelli   +3 more
doaj   +1 more source