Results 41 to 50 of about 69,943 (255)

Progress in research and applications of additively manufactured nickel-based superalloy in aero-engines and gas turbines

Journal of Aeronautical Materials
Nickel-based superalloy is an essential material to prepare hot-end components in aero-engines and gas turbines，due to its excellent mechanical properties under high temperature.
WU Yu, CHEN Bingqing, LIU Wei, HUANG Shuai, SUN Bingbing, ZHANG Xuejun, CHEN Pei, HUANG Chen   +7 more
doaj   +1 more source

Modelling and optimising hybrid process of wire arc additive manufacturing and high-pressure rolling

Materials & Design, 2022
Hybrid process of wire arc additive manufacturing (WAAM) and high-pressure rolling can build large-scale components with low detrimental residual stress (RS) and distortion. We developed an efficient coupled process model for a steel wall to simulate the
Valeriy Gornyakov, Yongle Sun, Jialuo Ding, Stewart Williams   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Optimum corrosion performance using microstructure design and additive manufacturing process control

npj Materials Degradation
Compatibility of traditional metallic alloys, particularly 316 L stainless steel, with additive manufacturing (AM) processes, is essential for industrial applications.
Parisa Moazzen, Ayda Shahriari, SeyedAmirReza Shamsdini, Payam Seraj, Foroozan Forooghi, Yahya Aghayar, Sajad Shakerin, Mackenzie Remington Purdy, Mohsen Mohammadi   +8 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Compositional criteria to predict columnar to equiaxed transitions in metal additive manufacturing

Nature Communications
Predicting the columnar to equiaxed transition (CET) and grain refinement for additively manufactured alloys from thermodynamic databases has been a long-standing challenge and an ongoing source of discussion.
Ryan Brooke, Duyao Zhang, Dong Qiu, Mark A. Gibson, Mark Easton   +4 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Effect of TiB₂ Addition on the Microstructure and Mechanical Properties of Laser-Directed Energy Deposition TiAl Alloy

Metals
The microstructure characteristics of TiAl alloy prepared by laser-directed energy deposition (L-DED) are coarse columnar grains parallel to the building direction, which results in serious mechanical properties and anisotropy and limits its application.
Yancheng Yang, Yi Hu, Hongyan Chen, Yu Li, Jiawei Wang, Xu Cheng, Haibo Tang, Xianzhe Ran, Dong Liu   +8 more
doaj   +1 more source