Results 31 to 40 of about 123,217 (264)

Modelling and optimising hybrid process of wire arc additive manufacturing and high-pressure rolling

Materials & Design, 2022
Hybrid process of wire arc additive manufacturing (WAAM) and high-pressure rolling can build large-scale components with low detrimental residual stress (RS) and distortion. We developed an efficient coupled process model for a steel wall to simulate the
Valeriy Gornyakov, Yongle Sun, Jialuo Ding, Stewart Williams   +3 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Design and Characterization of 2.5D Nature-Inspired Infill Structures under Out-Plane Quasi-Static Loading Condition

Advances in Materials Science and Engineering, 2023
The 2.5D (2.5-dimensional) structures are acquired to enhance safety and lightweight designs with better energy absorption in the aerospace and automobile sectors. Additive manufacturing (AM), which is practical to build suitable components in industrial
Dara Ashok, M. V. A. Raju Bahubalendruni
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Optimising the manufacturing of a β-Ti alloy produced via direct energy deposition using small dataset machine learning

Scientific Reports
Successful additive manufacturing involves the optimisation of numerous process parameters that significantly influence product quality and manufacturing success.
Ryan Brooke, Dong Qiu, Tu Le, Mark A. Gibson, Duyao Zhang, Mark Easton   +5 more
doaj   +1 more source

Control of crystallographic orientation by metal additive manufacturing process of β-type Ti alloys based on the bone tissue anisotropy [PDF]

MATEC Web of Conferences, 2020
Variation in the scanning strategy for β-type Ti alloys during additive manufacturing (AM) enables the fabrication of a singlecrystal-like microstructure possessing a crystallographic texture, in which the low-Young’s modulus- direction is aligned along ...
Nakano Takayoshi, Ishimoto Takuya, Matsugaki Aira, Hagihara Koji, Koizumi Yuichiro, Ozasa Ryosuke   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A novel experimental approach to exploring process parameters for fabricating support-free horizontal overhangs in LPBF of Inconel 718

Virtual and Physical Prototyping
The design freedom of Laser Powder Bed Fusion (LPBF) components has been confined by the minimum allowable overhang angle of 45°. It remains unclear how to achieve multiple layers of overhang at zero-degree overhang angle, which is the fundamental basis ...
Chun Kit Sit, Yunlong Tang, Louis N. S. Chiu, Samuel C. V. Lim, Yuman Zhu, Aijun Huang   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Non-destructive detection of critical defects in additive manufacturing

Scientific Reports
Non-destructive examination (NDE) based structural integrity assessment of additively manufactured (AM) metallic parts depends on the reliable detection of volumetric defects and the accurate representation of their detrimental features.
Shaharyar Baig, Alireza Jam, Stefano Beretta, Shuai Shao, Nima Shamsaei   +4 more
doaj   +1 more source