Results 101 to 110 of about 344,504 (276)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Author Correction: Recent increases in tropical cyclone intensification rates

open access: yesNature Communications, 2019
The original version of this Article contained an error in the second sentence of the first paragraph of the ‘Quantile mapping’ section of the Methods, which incorrectly read ‘We primarily focus on results produced using an additive version of QDM26 by ...
Kieran T. Bhatia   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Preschoolers’ interpretation of habitual and deontic conditionals: a delayed mapping between concept and language

open access: yesJournal of Child Language Acquisition and Development, 2020
By investigating Dutch children’s interpretation habitual and deontic conditionals, this paper explores their mapping of the concepts of hypotheticality and conditionality into a corresponding linguistic form of IF-conditionals.
Jing Lin
doaj   +4 more sources

Additivity of Reverse Derivable Maps

open access: yes, 2018
There is a technical error in the hypothesis of the main ...
Sandhu, Gurninder Singh, Kumar, Deepak
openaire   +2 more sources

On stability of additive mappings [PDF]

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1991
In this paper we answer a question of Th. M. Rassias concerning an extension of validity of his result proved in [3].
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Fixed Points, Inner Product Spaces, and Functional Equations

open access: yesFixed Point Theory and Applications, 2010
Rassias introduced the following equality ∑i,j=1n∥xi-xj∥2=2n∑i=1n∥xi∥2, ∑i=1nxi=0, for a fixed integer n≥3. Let V,W be real vector spaces.
Choonkil Park
doaj   +1 more source

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