Results 141 to 150 of about 291,054 (244)

Post-Fire Forest Pulse Recovery: Superiority of Generalized Additive Models (GAM) in Long-Term Landsat Time-Series Analysis. [PDF]

Sensors (Basel)
Arij N, Malihi S, Kiani A.
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Varying-Coefficient Additive Models with Density Responses and Functional Auto-Regressive Error Process. [PDF]

Entropy (Basel)
Han Z, Li T, You J, Balakrishnan N.
europepmc   +1 more source

General additive models address statistical issues in diffusion MRI: An example with clinically anxious adolescents. [PDF]

Neuroimage Clin, 2022
Muncy NM, Kimbler A, Hedges-Muncy AM, McMakin DL, Mattfeld AT.   +4 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

dGAMLSS: an exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts. [PDF]

Bioinformatics
Hu F, Tong J, Gardner M, Lifespan Brain Chart Consortium , Chen AA, Bethlehem RAI, Seidlitz J, Li H, Alexander-Bloch A, Chen Y, Shinohara RT.   +10 more
europepmc   +1 more source

Spike-and-slab least absolute shrinkage and selection operator generalized additive models and scalable algorithms for high-dimensional data analysis. [PDF]

Stat Med, 2022
Guo B, Jaeger BC, Rahman AKMF, Long DL, Yi N.   +4 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Assessing the relationship between training load and injury in ultramarathon runners: a novel approach using Generalised Additive Models. [PDF]

S Afr J Sports Med
Burgess TL, Durand P, Buchholtz K.
europepmc   +1 more source

Physical Activity and Total Daily Energy Expenditure in Older US Adults: Constrained versus Additive Models. [PDF]

Med Sci Sports Exerc, 2022
Willis EA, Creasy SA, Saint-Maurice PF, Keadle SK, Pontzer H, Schoeller D, Troiano RP, Matthews CE.   +7 more
europepmc   +1 more source