Results 121 to 130 of about 83,570 (309)

Language Functions Used by the Main Character in Sherlock Holmes II: a Game of Shadows Movie [PDF]

open access: yes, 2014
This research focused on language functions used by the main character in “Sherlock Holmes” movie. The aims were to find the use of language functions and describe the dominant types of language functions used in “Sherlock Holmes” movie.
Arista, S. D. (Sri), Murni, S. M. (Sri)
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

POLYCODE TEXT AS A SPACE OF CONFLICTOGENITY MANIFESTATION

open access: yesВестник Волгоградского государственного университета: Серия 2. Языкознание
The article is devoted to the identification of the linguasemiotic features of a polycode text as a space for manifestation of conflictogenicity. The novelty of the research consists in a detailed examination of the graphic and verbal components of a ...
Oleg A. Alimuradov   +2 more
doaj   +1 more source

PERSONAL DEIXIS IN RADIO BROADCAST: EXTINCTION SIGNAL OF ‘KAMI’IN INDONESIAN [PDF]

open access: yes, 2016
In Indonesian, “kami” means ‘we’, which exclusively refers to the speaker and somebody else or other people but the addressee(s) or hearers. In English, to understand ‘we’ is not as simple as in ‘kami (exclusive ‘we’)’ and ‘kita (inclusive ‘we’)’ in ...
Oktarani , Yesika Maya   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Elementary Persuasive Letter: Two Cases Of Situated Competence, Strategy, And Agency [PDF]

open access: yes, 2008
Research on persuasive writing by elementary children posits primarily a developmental perspective, claiming that elementary-age children can effectively argue through talk but not through writing.
Anderson, Diane Downer
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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