Results 101 to 110 of about 83,570 (309)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Publicističeskij tekst i ego stilističeskie osobennosti
Stylistyka, 2010 The displacement o f a scientific paradigm has occurred in modem linguistics: the transition from the systematic approach to the study o f language in the communicative approach.
Natalʹâ I. Klušina
doaj
The Intentional Aspect of the Russian-Language Infographics of the 21 st Century
Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2018 The paper is devoted to the study of semiotically heterogeneous texts – inforgraphics, which are an important element of modern communication and are used in various spheres of life.
Margarita M. Makhrova
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Inférences réflexives dans la publicité [PDF]
, 2009 Advertisements are so ubiquitous nowadays that capturing the addressee’s attention and maintaining it long enough for them to be fully processed have become fundamental objectives for advertisers. Employing specific strategies in the design of the
Merino Ferradá, María del Carmen
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The factor of the addresser and addressee in media discourse
Polylinguality and Transcultural Practices, 2014 The article reviews the specificity of interaction between addresser and addressee in the modern media discourse and the role of the addressee as an active participant in one way or another defining the activities of the addresser in the process of ...
B I Karadzhev
doaj