Results 91 to 100 of about 1,692 (246)

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Internal and External Structure of Ruthenian Letters in Early Modern Lithuania

open access: yesLietuvos Istorijos Studijos, 2019
A thorough analysis of approximately one hundred unpublished and about seventy published letters written by Lithuanian noblemen and the Grand Duke of Lithuania led to a conclusion that there were three distinct types of letters.
Andrej Ryčkov
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Linguocreative components of the Spanish print media in the communicative aspect of “addresser-addressee”

open access: yes, 2016
The object of research of the article is the “qualitative” Spanish media: linguocreative means of analytical newspaper articles used as a means for dialogization in the communicative aspect of “addresser-addressee” are analyzed here.
Elena Nikolaevna Remchukova   +1 more
core  

The Semantics of -ketun in Korean [PDF]

open access: yes, 2005
The conditional connective -ketun in Korean has some restrictions in both the antecedent clause and the consequent clause. In the antecedent clause the event or state denoted by the predicate must be perceptible.
Yeom, Jae-Il
core  

The Structural-Communicative Pattern of Hadiqa's Tales [PDF]

open access: yesمتن شناسی ادب فارسی, 2011
Hadiqa is the first significant collection of verse in Persian. In this great work, Sanai addresses mystical subjects and elaborates on Islamic moral principles.
B Mirzaei   +3 more
doaj  

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