Results 71 to 80 of about 1,692 (246)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Discourse of internet comments: the relationship between the addresser and addressee
, 2008 Reikšminiai žodžiai: Adresantas; Adresatas; Diskursas; Emocionalumas; Internetiniai komentarai; Žiniasklaida; Addresse; Addressee; Addresser; Discourse; Emotionality; Internet comments ...
Vaitkevičienė, Laima
core
Dialogo adresantas ir adresatas [PDF]
, 1998 One of the distinctive features of dialogue, when compared with the monologue, is the categories of the addresser and the addressee. The addresser is considered to be the person who creates the message while the person to whom this message is addressed ...
Vilkienė, Loreta
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Deconstruction of Russia Anthem: Identification of Discoursive Forces of Interaction
Дискурс Пи, 2017 The article describes the features of discourse powers and lingua-cognitive mechanisms used in the Russian anthem for interaction between the addresser with the addressee.
I.A. Yakoba
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Adresat v âzykovoj kommunikacii
, 2021 The paper describes the parameters of verba I communication with the addressee playingan active part as:I ) the addresser's coauthor when choosing the topie, the style, the genre, the metalanguageetc.;2) the recipient, who receives, understands and ...
Formanovskaâ, N. I.
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source