Results 261 to 270 of about 409,167 (281)

Deficiency of N1-Adenine Methyltransferase Aggravates RNA and Protein Aggregation. [PDF]

Cells
Alriquet M, Arsiè R, Calloni G, Tartaglia GG, Vabulas RM.   +4 more
europepmc   +1 more source

Fungal Biodiversity From the Atlantic Forest With Bioactive Metabolites Against Cutaneous Leishmaniasis

Chemistry &Biodiversity, EarlyView.
ABSTRACT Biodiversity offers a rich source of bioactive compounds for drug discovery. We isolated Aspergillus fumigatus from compost in the Atlantic Forest and found its extract active against Leishmania (Leishmania) amazonensis. Two crude extracts, I06 and I75, were selected for further study.
Juliana Cristina Pereira Calado, Marina Valente Navarro, Alison Felipe Alencar Chaves, Isis Casula, Patricia Locosque Ramos, João Batista da Cruz, Anderson Messias Rodrigues, Keith Dayane Leite Lira, Fernando Luiz Affonso Fonseca, Patricia Xander, Suzan Pantaroto de Vasconcellos, Wagner Luiz Batista   +11 more
wiley   +1 more source

The OsteoSense Imaging Agent Identifies Organ-Specific Patterns of Soft Tissue Calcification in an Adenine-Induced Chronic Kidney Disease Mouse Model. [PDF]

Int J Mol Sci
Lente G, Tóth A, Balogh E, Csiki DM, Nagy B, Szöőr Á, Jeney V.   +6 more
europepmc   +1 more source

Phenolic Compounds From Myrcia tijucensis: Insights Into Antioxidant and Antidiabetic Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT The genus Myrcia from the Myrtaceae family contains species with therapeutic properties, such as reducing glycemia and oxidative stress. This study investigated the effects of the hydroalcoholic extract of Myrcia tijucensis in an animal model of Type 1 diabetes induced by alloxan.
Nathielli Nayara Pauleti, Brenda Wiggers, Ana Luiza de Moraes G. Boaventura, Ana Carolina Dutra, Luiz Guilherme de Alcantara Grilo, Jan Pereira Wotmeyer, Camila Jeriane Paganelli, Camila Panini, Rafaela Beatriz Cunha, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Micke, Daniela Delwing‐de Lima, Débora Delwing‐Dal Magro   +13 more
wiley   +1 more source

Identification of potential biomarkers for diabetic nephropathy via UPLC-MS/MS-based metabolomics. [PDF]

Front Endocrinol (Lausanne)
Chen H, Du P, Jiang T, Li Y, Li Y, Liu Y, Yang B, Kang J, Duan J, Ma Y, Chen X, Jiang H.   +11 more
europepmc   +1 more source

Functional Analysis of Histidine‐Dependent Self‐Cleaving RNAs Obtained by In Vitro Selection

ChemBioChem, EarlyView.
Ribozymes can be nucleic acid medicines given their catalytic activity. We attempted to obtain functional RNAs that mimic ribonuclease A catalytic mechanisms. Functional RNAs with high histidine specificity were obtained, suggesting that histidine acts in active structure formation.
Nae Sakimoto, Shoichiro Tanaka, Riki Hatakenaka, Yoshie Yamaguchi‐Miyazaki, Elisa Tomita‐Sudo, Tomoka Akita, Taku Ishigaki, Shigenori Iwai, Junji Kawakami   +8 more
wiley   +1 more source

UV-SERS monitoring of plasmonic photodegradation of biomolecules on aluminum platforms decorated with rhodium nanoparticles. [PDF]

Nanoscale Adv
Zou Y, Mattarozzi L, Jin H, Ma Q, Cattarin S, Weng S, Douaki A, Lanzavecchia G, Kołątaj K, Corduri N, Johns B, Maccaferri N, Acuna G, Zheng Z, Jin S, Garoli D.   +15 more
europepmc   +1 more source

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

A Liposomal Formulation Enhances the Anti-Senescence Properties of Nicotinamide Adenine-Dinucleotide (NAD⁺) in Endothelial Cells and Keratinocytes. [PDF]

Curr Issues Mol Biol
Ministrini S, Liberale L, Erle HE, Percoco G, Tfayli A, Assi A, Kapitonov I, Greiner I, Camici GG.   +8 more
europepmc   +1 more source

Development and Validation of a High‐Throughput Screening Assay for the Legionella ADP‐Ribosyl Transferase SdeA

ChemBioChem, EarlyView.
We show the optimization and application of a fluorogenic assay to monitor Legionella SdeA activity in a High‐Throughput‐Screening campaign. Ubiquitination of proteins is one of the most crucial post‐translational modifications in eukaryotic cells, typically involving conjugation of ubiquitin to a lysine residue in a substrate using a three‐enzyme ...
Halana C. Vlaming, Vito Pol, Bjorn R. van Doodewaerd, Angeliki Moutsiopoulou, Paul P. Geurink, Robbert Q. Kim, Gerbrand J. van der Heden van Noort   +6 more
wiley   +1 more source