Results 271 to 280 of about 399,190 (328)

Establishment and Comparison of Detection Methods for Ricin and Abrin Based on Their Depurination Activities. [PDF]

Toxins (Basel)
Dong L, Liu T, Li J, Wang C, Lv J, Wang J, Wang J, Gao S, Kang L, Xin W.   +9 more
europepmc   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Recombinant ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) decreases vascular calcification and prevents osteomalacia in a rat model of chronic kidney disease. [PDF]

JBMR Plus
O'Brien K, Laurion L, Sullivan C, Howe J, Lynch AM, Cheng Z, Schrier D, Husson H, Sabbagh Y.   +8 more
europepmc   +1 more source

Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome

ChemBioChem, EarlyView.
The Psilocybe cubensis terpene synthases, CubB‐CubE, were investigated. Product formation assays identified CubB as a (3R,6E)‐(‐)‐nerolidol or linalool synthase, whereas CubC is a multiproduct synthase catalyzing the formation of β‐caryophyllene and other linear and cyclic sesquiterpenes/‐terpenoids.
Nick Zschoche, Sebastian Schober, Karl Walther, Andrew R. Chadeayne, Markus Gressler, Stefan Bartram, Sarah E. O’Connor, Dirk Hoffmeister   +7 more
wiley   +1 more source

Generation of Immune Modulating Small Metabolites-Metabokines-By Adult Schistosomes. [PDF]

Pathogens
Skelly PJ, Da'dara AA.
europepmc   +1 more source

Structural Basis of Regioselective Bromination of Tricyclic Tryptoline by the Tryptophan Halogenase Thal

ChemBioChem, EarlyView.
This study shows that the flavin‐dependent tryptophan halogenase Thal also regioselectively halogenates the tricyclic non‐native substrate tryptoline, a β‐carboline with various pharmacological activities. Interestingly, Thal brominates a different position of the shared pharmacophore indole in tryptoline than it does in tryptophan. A crystal structure
Simon Bork, Caroline Besse, Norbert Sewald, Hartmut H. Niemann   +3 more
wiley   +1 more source

Regeneration of selected callus of three potato cultivars (Solanum tuberosum.L) and studying their tolerance to drought stress. [PDF]

BMC Plant Biol
Laila LA, Zaid SH, Al-Biski F, Dakah A.
europepmc   +1 more source

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration

ChemBioChem, EarlyView.
In tRNA aminoacylated nucleosides represent the central transfer unit of amino acids. An occurring 2′‐3′‐transaminoacylation is biomimetically exploited to successfully synthesize nucleosidic acid esters. This approach can be further expanded on sulfonic acid esters, which has the potential of a broad range of stereo‐ and regio‐controlled modifications
Nathalie J. Kurrle, Christoph J. B. Seifert, Nathalie Hampel, Tamara Rauch, Michael Thoma, Luca V. Parziale, Marian S. R. Ebeling, Dino Berthold, Oliver Trapp   +8 more
wiley   +1 more source

Crystalline Nephropathy Due to 2,8-Dihydroxyadeninuria in a Transplanted Kidney: 2 Case Reports. [PDF]

Am J Case Rep
Raza HMA, Ibrahim A, Talwar M, Balaraman V, Bhalla A, Wall BM, Cossey LN.   +6 more
europepmc   +1 more source

Shifting the Substrate Scope of an Ene/Yne‐Reductase by Loop Engineering

ChemCatChem, EarlyView.
A flexible active‐site loop that is involved in shaping the substrate and product cleft as well as the active‐site pocket was identified for the MDR‐related ene/yne‐reductase CaeEnR1 from Cyclocybe aegerita. Double mutations of this loop showed an up to 20‐fold increase in conversion rates toward cinnamaldehyde‐like substrates and a 2‐fold increase in ...
Dominik Karrer, Erika Wedler, Carolin Mewe, Martin Gand, Marian Vogt, Lukas Korf, Lars‐Oliver Essen, Martin Rühl   +7 more
wiley   +1 more source