Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress [PDF]
Biochemistry Research International, 2020 Mitochondrial permeability transition is characterized by the opening of a transmembranal pore that switches membrane permeability from specific to nonspecific.
Edmundo Chávez +5 more
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Adenine Nucleotide Translocase 1 Expression Modulates the Immune Response in Ischemic Hearts [PDF]
Cells, 2021 Adenine nucleotide translocase 1 (ANT1) transfers ATP and ADP over the mitochondrial inner membrane and thus supplies the cell with energy. This study analyzed the role of ANT1 in the immune response of ischemic heart tissue. Ischemic ANT1 overexpressing
Fatih Yergöz +6 more
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25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca2+ Mobilizing Second Messengers Together with Professor Barry Potter [PDF]
Molecules, 2020 Ca2+-mobilizing adenine nucleotide second messengers cyclic adenosine diphosphoribose, (cADPR), nicotinic acid adenine dinucleotide phosphate (NAADP), adenosine diphosphoribose (ADPR), and 2′deoxy-ADPR were discovered since the late 1980s.
Andreas H. Guse
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Mitochondrial adenine nucleotide transport and cardioprotection [PDF]
Journal of Molecular and Cellular Cardiology, 2012 Mitochondria are highly metabolically active cell organelles that not only act as the powerhouse of the cell by supplying energy through ATP production, but also play a destructive role by initiating cell death pathways. Growing evidence recognizes that mitochondrial dysfunction is one of the major causes of cardiovascular disease.
Samarjit, Das, Charles, Steenbergen
openaire +3 more sources
The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide [PDF]
MedCommFerroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation of lipids within cellular membranes. Ferroptosis plays a crucial role in physiological and pathological situations and
Shijian Feng +8 more
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Adenine Nucleotide Translocase 1 Expression is Coupled to the HSP27-Mediated TLR4 Signaling in Cardiomyocytes. [PDF]
Cells, 2019 The cardiac-specific overexpression of the adenine nucleotide translocase 1 (ANT1) has cardioprotective effects in various experimental heart disease models.
Winter J +6 more
europepmc +4 more sources
Biomedicines, 2022 Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac +6 more
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Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus. [PDF]
PLoS ONE, 2012 Mitochondria from the embryos of brine shrimp (Artemia franciscana) do not undergo Ca(2+)-induced permeability transition in the presence of a profound Ca(2+) uptake capacity. Furthermore, this crustacean is the only organism known to exhibit bongkrekate-
Csaba Konrad +4 more
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Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. [PDF]
PLoS ONE, 2009 BACKGROUND:The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF.
Martin Lubin, Adam Lubin
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Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 The adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP across the inner mitochondrial membrane. The human genome encodes multiple ANT isoforms that are expressed in a tissue-specific manner.
Takashi Hamazaki +5 more
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