Results 31 to 40 of about 370,851 (253)
Nature Communications, 2021 The nature of the mitochondrial permeability transition pore (PTP) is still under debate. Here, through genetically modified F-ATP synthase, the authors show that PTP formation can be mediated by F-ATP synthase or by adenine nucleotide translocator ...
Andrea Carrer +10 more
doaj +1 more source
Probabilistic models of biological enzymatic polymerization.
PLoS ONE, 2021 In this study, hierarchies of probabilistic models are evaluated for their ability to characterize the untemplated addition of adenine and uracil to the 3' ends of mitochondrial mRNAs of the human pathogen Trypanosoma brucei, and for their generative ...
Marshall Hampton +3 more
doaj +1 more source
Protocol for targeted modification of the rice genome using base editing
STAR Protocols, 2022 Summary: Base editing is a precision genome-editing approach that is widely utilized to generate single-nucleotide variants (SNVs) in genomes. Here, we present a protocol to perform targeted adenine (A)-to-guanine (G) substitution in rice using adenine ...
Meixia Wang, Fang Yan, Huanbin Zhou
doaj +1 more source
Adenine nucleotide depletion from endothelial cells exposed to xanthine oxidase
, 1990 Hypoxia causes breakdown of cellular nucleotides, accumulation of hypoxanthine (HX), and conversion of xanthine dehydrogenase into xanthine oxidase (XO).
K. O. Raivio, T. K. Aalto
core +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
mBio, 2017 Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observed to
Naganori Nao +12 more
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Adenine nucleotide degradation in the rabbit heart
, 1964 Adenine nucleotide analysis of tissue and perfusates of the isolated rabbit heart were undertaken following hypoxia and uncoupled oxidative phosphorylation.
Leigh Wyborny, Harold G. Richman
core +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
CellsPrevious work has shown that mouse models fed a non-obesogenic high-fat diet have preserved cardiac function and no obesity-associated comorbidities such as diabetes.
Jihad S. Hawi +5 more
doaj +1 more source
Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets
eLife, 2015 MicroRNAs (miRNAs) direct post-transcriptional regulation of human genes by guiding Argonaute proteins to complementary sites in messenger RNAs (mRNAs) targeted for repression.
Nicole T Schirle +4 more
doaj +1 more source