Results 51 to 60 of about 370,851 (253)
Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics
Angewandte Chemie, EarlyView.Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee +4 more
wiley +2 more sources
BiomoleculesThe Escherichia coli adenine-DNA glycosylase (MutY) and its human homologue, MUTYH, protect cells against oxygen-free radical-induced mutagenesis by excising regular adenine impaired with 8-oxo-7,8-dihydro-guanine (8oxoG) in the base excision repair (BER)
Ulan Sarsenbayeva +11 more
doaj +1 more source
Antagonism of Morphine Analgesia by Adenine, Adenosine, and Adenine Nucleotides
Experimental Biology and Medicine, 1973 SummaryAntagonism of the antinociceptive action of morphine in mice by prior parenteral administration of cAMP has been confirmed using two additional analgesic testing procedures, the hot-plate test and the stretching test. The analgesia-antagonistic property, however, is not specific for cAMP because it also occurred after pretreatment with compounds
D R, Gourley, S K, Beckner
openaire +2 more sources
Evaluation of Immobilized Boronates for Studies of Adenine Nucleotide Metabolism [PDF]
, 1982 Immobilized boronates were evaluated for studies of adenine nucleotide metabolism. These studies were performed using Affi-gel 601, a commercial boronate gel, and dihydroxyboryl Sepharose and dihydroxyboryl-Bio Rex which were synthesized in the ...
Alvarez-Gonzalez, Rafael
core
, 1977 Highly purified adenine nucleotide transporter from bovine heart mitochondria was reconstituted with phospholipids to form vesicles which catalyzed atractyloside-sensitive adenine nucleotide translocation.
Racker, Efraim +3 more
core +1 more source
The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools [PDF]
, 2023 Paratrimastix pyriformis is a free-living flagellate thriving in low-oxygen freshwater sediments. It belongs to the group Metamonada along with human parasites, such as Giardia and Trichomonas. Like other metamonads, P.
Peña-Diaz, Priscila +6 more
core +1 more source
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
PLoS ONE, 2013 Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent. Recombinant human Apo2L/TRAIL has been under clinical trials, whereas various kinds of malignant tumors have resistance to Apo2L ...
Masakatsu Oishi +5 more
doaj +1 more source
Hidden Pool of Cardiac Adenine Nucleotides That Controls Adenosine Production
Pharmaceuticals, 2023 Myocardial ischemic adenosine production decreases in subsequent events that may blunt its protective functions. To test the relation between total or mitochondrial cardiac adenine nucleotide pool (TAN) on the energy status with adenosine production ...
Magdalena A. Zabielska-Kaczorowska +4 more
doaj +1 more source
Binding of adenine nucleotides to mitochondrial membrane [PDF]
FEBS Letters, 1975 It has been reported from different laboratories [l-4] that mitochondria are capable of binding ATP. However the exact magnitude of binding, and the relevance of this process to the mechanism of oxidative phosphorylation are still unknown, due to the extremely low amounts of bound nucleotides, and to some difficulties in carrying out the measurements ...
Alexandre, A. +2 more
openaire +2 more sources