The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition [PDF]
Cells, 2020 The mitochondrial permeability transition, a Ca2+-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies.
Nickolay Brustovetsky
exaly +9 more sources
Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status [PDF]
Open Biology, 2016 Human cells express four mitochondrial adenine nucleotide translocase (hANT) isoforms that are tissue-specific and developmentally regulated. hANT1 is mainly expressed in terminally differentiated muscle cells; hANT2 is growth-regulated and is ...
Aleix Gavaldà Navarro
exaly +5 more sources
Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress [PDF]
Biochemistry Research International, 2020 Mitochondrial permeability transition is characterized by the opening of a transmembranal pore that switches membrane permeability from specific to nonspecific.
Edmundo Chávez +5 more
doaj +3 more sources
Adenine Nucleotide Translocase 1 Expression Modulates the Immune Response in Ischemic Hearts [PDF]
Cells, 2021 Adenine nucleotide translocase 1 (ANT1) transfers ATP and ADP over the mitochondrial inner membrane and thus supplies the cell with energy. This study analyzed the role of ANT1 in the immune response of ischemic heart tissue. Ischemic ANT1 overexpressing
Fatih Yergöz +6 more
doaj +2 more sources
Mitochondria Isolated from Hearts Subjected to Ischemia/Reperfusion Benefit from Adenine Nucleotide Translocase 1 Overexpression [PDF]
Membranes, 2021 Reperfusion is the only feasible therapy following myocardial infarction, but reperfusion has been shown to damage mitochondrial function and disrupt energy production in the heart.
Andrea Dörner +5 more
doaj +2 more sources
Conformational change of adenine nucleotide translocase‐1 mediates cisplatin resistance induced by EBV‐LMP1 [PDF]
EMBO Molecular Medicine, 2021 Adenine nucleotide translocase‐1 (ANT1) is an ADP/ATP transporter protein located in the inner mitochondrial membrane. ANT1 is involved not only in the processes of ADP/ATP exchange but also in the composition of the mitochondrial membrane permeability ...
Lin Zhao +10 more
doaj +2 more sources
Possible Participation of Adenine Nucleotide Translocase ANT1 in the Cytotoxic Action of Progestins, Glucocorticoids, and Diclofenac on Tumor Cells [PDF]
Pharmaceutics, 2023 A comparative analysis of the cytostatic effects of progestins (gestobutanoyl, megestrol acetate, amol, dienogest, and medroxyprogesterone acetate), glucocorticoids (hydrocortisone, dexamethasone), and diclofenac on tumor cells was carried out in order ...
Darya Ulchenko +4 more
doaj +2 more sources
A Fluorescence-Based Method to Measure ADP/ATP Exchange of Recombinant Adenine Nucleotide Translocase in Liposomes [PDF]
Biomolecules, 2020 Several mitochondrial proteins, such as adenine nucleotide translocase (ANT), aspartate/glutamate carrier, dicarboxylate carrier, and uncoupling proteins 2 and 3, are suggested to have dual transport functions.
Jürgen Kreiter +2 more
doaj +2 more sources
Adenine Nucleotide Translocase: From Nucleotide Carrier to a Modulator of Mitochondrial Bioenergetics, Quality Control, and Cellular Communication [PDF]
CellsAdenine nucleotide translocase (ANT) has traditionally been defined as the ADP/ATP exchanger of the inner mitochondrial membrane. However, accumulating mechanistic evidence reveals a substantially broader functional spectrum that extends beyond ...
Ursula Rauch-Kroehnert +3 more
doaj +2 more sources
The essential role of adenine nucleotide translocase 4 on male reproductive function in mice [PDF]
Brazilian Journal of Medical and Biological ResearchAdenine nucleotide translocator 4 (Ant4), an ATP/ADP transporter expressed in the early phases of spermatogenesis, plays a crucial role in male fertility.
Fengyuan Yang +10 more
doaj +2 more sources