Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast [PDF]
SLAS Discovery, 2016 Jon E Hawkinson +2 more
exaly +2 more sources
Identification of adenine nucleotide translocase 4 inhibitors by molecular docking. [PDF]
J Mol Graph Model, 2013 The protein adenine nucleotide translocase (ANT) is localized in the mitochondrial inner membrane and plays an essential role in transporting ADP into the mitochondrial matrix and ATP out from the matrix for cell utilization. In mammals there are four paralogous ANT genes, of which ANT4 is exclusively expressed in meiotic germ cells.
Leung WY +3 more
europepmc +4 more sources
Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus. [PDF]
PLoS ONE, 2012 Mitochondria from the embryos of brine shrimp (Artemia franciscana) do not undergo Ca(2+)-induced permeability transition in the presence of a profound Ca(2+) uptake capacity. Furthermore, this crustacean is the only organism known to exhibit bongkrekate-
Csaba Konrad +4 more
doaj +1 more source
Adenine Nucleotide Translocase 4 Is Expressed Within Embryonic Ovaries and Dispensable During Oogenesis [PDF]
Reproductive Sciences, 2015 Jeffrey V Brower +2 more
exaly +2 more sources
Depletion of Toxoplasma adenine nucleotide translocator leads to defects in mitochondrial morphology
Parasites & Vectors, 2022 Background Adenine nucleotide translocase (ANT) is a protein that catalyzes the exchange of ADP/ATP across the inner mitochondrial membrane. Beyond this, ANT is closely associated with cell death pathways and mitochondrial dysfunction.
Yihan Wu +5 more
doaj +1 more source
Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. [PDF]
PLoS ONE, 2014 In this study, we compared the influence of GDP and GTP on isolated mitochondria respiring under conditions favoring oxidative phosphorylation (OXPHOS) and under conditions excluding this process, i.e., in the presence of carboxyatractyloside, an adenine
Andrzej M Woyda-Ploszczyca +1 more
doaj +1 more source
The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast [PDF]
, 2013 The ADP/ATP carrier protein (AAC) expressed in Artemia franciscana is refractory to bongkrekate. We generated two strains of Saccharomyces cerevisiae where AAC1 and AAC3 were inactivated and the AAC2 isoform was replaced with Artemia AAC containing a ...
Adam-Vizi, Vera +48 more
core +2 more sources
Lipid-Loving ANTs: Molecular Simulations of Cardiolipin Interactions and the Organization of the Adenine Nucleotide Translocase in Model Mitochondrial Membranes. [PDF]
Biochemistry, 2016 The exchange of ADP and ATP across the inner mitochondrial membrane is a fundamental cellular process. This exchange is facilitated by the adenine nucleotide translocase, the structure and function of which are critically dependent on the signature ...
Hedger G +5 more
europepmc +2 more sources
The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species
Cells, 2023 The demonstration that F1FO (F)-ATP synthase and adenine nucleotide translocase (ANT) can form Ca2+-activated, high-conductance channels in the inner membrane of mitochondria from a variety of eukaryotes led to renewed interest in the permeability ...
Elena Frigo +4 more
doaj +1 more source
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Nature Communications, 2017 Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin ...
Joonseok Cho +19 more
doaj +1 more source